Workaholism is an addiction, however the obsessive-compulsive components alone may prove insufficient in determining its nature.

The aim of the following study was to determine the mediating role of depressiveness in the relationships between workaholism and personality traits according to the five-factor model among Polish women.

The research study was carried out among 556 women residing in the West Pomeranian Voivodeship in Poland. The research was based on a survey performed using a questionnaire technique. The following research instruments adapted to Polish conditions were employed to assess the incidence of work addiction among female adults: The NEO Five-Factor Inventory (NEO-FFI), The Work Addiction Risk Test (WART) Questionnaire, and The Beck Depression Inventory–BDI I-II.

A positive correlation between the intensity of neuroticism and the work addiction risk was revealed (β = 0.204, p < 0.001). A partial mediation (35%) with the severity of depression symptoms as a mediating factor was observed (β = 0.110, p < 0.001). Respondents characterized by high neuroticism showed a greater severity of the symptoms of depression (β = 0.482, p < 0.001), which is a factor increasing the work addiction risk (β = 0.228, p < 0.001). Respondents characterized by a high level of extraversion displayed lower severity of the symptoms of depression (β = –0.274, p < 0.001). A negative correlation between the intensity of agreeableness and the work addiction risk was revealed (β = –0.147, p < 0.001). A partial mediation (27.8%) was observed. A positive correlation between the intensity of conscientiousness and the work addiction risk was revealed (β = 0.082, p = 0.047). Respondents characterised by a high level of conscientiousness showed a lower severity of depression symptoms (β = –0.211, p < 0.001).

Table 1. Indirect and total effects: Mediation model 1 - Neuroticism

NEU—neuroticims, WART—Work Addiction Risk Test, N – Neuroticism, BDI—Beck Depression Inventory–BDI I-II, b—unstandardized regression coefficient, β—standardized regression coefficient, p—significance level; * Confidence interval (CI) computed with method: bootstrap percentiles; ** Beta (β) is completely standardized effect size.

Depressiveness plays the role of a mediator between neuroticism, extraversion, agreeableness as well as conscientiousness, and work addiction. Depressiveness is a factor which increases the risk of work addiction.

None Declared

BEHAVIORAL ADDICTIONS AS A REPETITIVE PATTERN OF BEHAVIOR WITH DECREASE IN SELF-CONTROL AND A POWERFUL DESIRE TO CARRY OUT IT, DESPITE THE NEGATIVE CONSEQUENCES; WITH ACCOMPANYING SYMPTOMATOLOGY OF IRRITABILITY, CONCERN AND ANXIETY.

ANALYZE THE RESULTS ON REPORTS OF BEHAVIORAL ADICTIONS

IN THE REPORTS ON BEHAVIORAL ADDICTIONS, ESTUDES (SURVEY ON THE DRUG USE IN SECONDARY EDUCATION IN SPAIN, 14-18 YEARS OLD) AND EDADES (SURVEY ON ALCOHOL AND DRUGS IN SPAIN) WE FOUND THE FOLLOWING:

• - MANY MINORS PARTICIPATE IN GAMBLING GAMES.

• - THE USE OF THE INTERNET, GAMBLING WITH MONEY AND VIDEO GAMES ARE VERY COMMON PRACTICES.

• - ONLINE BETTING GAMES ARE MORE PREVALENT IN YOUNG PEOPLE.

• - WITHIN THE PATHOLOGICAL GAME, A GREATER PREVALENCE OF BEHAVIOR IS OBSERVED RISK.

• - WITHIN THE ABUSIVE USE OF THE INTERNET, GREATER CONSUMPTION OF CANNABIS AND ALCOHOL.

REGARDING THE TREATMENT, THE USEFULNESS OF COGNITIVE PSYCHOTHERAPY IS RECOGNIZED. BEHAVIORAL AND THE USE OF PSYCHODRUGS SUCH AS NALMEFENE AND NALTREXONE.

ADDICTION TO THE INTERNET AND VIDEO GAMES COULD BE RECOGNIZED AS PSYCHIATRIC DIAGNOSES WHEN THEY LEAD MORE COMPLEX CHARACTERISTICS. SOME STUDIES PROPOSED TO TAKE INTO ACCOUNT THE EMOTIONAL NEEDS AND THE IMPULSIVITY, WHILE OTHERS, TALK ABOUT THE NEURO-BIOLOGICAL-GENETIC COMPONENT OF ADDICTIONS.

None Declared

Opioid dependence is a complex condition that often requires long-term treatment and care. Methadone, a synthetic full opioid agonist, and buprenorphine, a partial agonist at the opioid receptor, are commonly used in substitution therapy for opioid dependence, typically administered as an oral liquid or sublingual tablet. Transitioning from high-dose methadone to buprenorphine for the treatment of opioid use disorder (OUD) poses a risk of precipitated withdrawal. This risk arises from introducing a high-affinity partial agonist (buprenorphine) at the mu-opioid receptor after it has been occupied by a lower-affinity full agonist (methadone). As a result, this transition is usually only performed for patients on low doses of methadone (<30-40 mg). Microdose induction has been proposed as a potential solution to facilitate a smoother transition to buprenorphine.

To present a case report of a rapid transition from high-dose methadone to buprenorphine depot, highlighting both the benefits and challenges of this process.

This case report describes a patient who was switched from 150 mg of methadone to 32 mg of sublingual buprenorphine using microdosing, and subsequently transitioned to a weekly 160 mg buprenorphine depot injection.

The patient was successfully transitioned to sublingual buprenorphine and later to buprenorphine depot without experiencing withdrawal symptoms. Even later, the patient reported no signs of withdrawal and was satisfied with the buprenorphine dosage. The patient attended monthly check-ups with the doctor; however, 15 days after the transition, he began consuming alcohol and soon after, started using cocaine.

This report supports the use of microdose induction for initiating buprenorphine, particularly for patients stabilized on high doses of methadone who may struggle with traditional buprenorphine induction methods. Although the patient remained abstinent from opioids, he quickly relapsed with alcohol and cocaine, issues that had not been present during his methadone treatment. Regular and more frequent therapeutic assessments are very important for many patients to prevent relapse.

None Declared

Although stigmatization is a barrier to treatment for many individuals and groups, individuals with mental disorders are the most affected by stigmatization. Among mental disorders, substance use disorders are the group with high levels of social stigma and internalized stigma. Internalized stigma may lead to a decrease in self-esteem and withdrawal from society and may increase depressive symptoms. Among individuals who use substances, depressive symptoms are high due to both the effects of the substances used and the psychosocial and legal problems experienced. In the literature review, no study examining the relationship between internalized stigma and depression in adolescents was found.

This study aimed to examine the relationship between internalized stigma and depression in a group of adolescents diagnosed with substance use disorder.

The study was conducted between December 2023-March 2024 with 71 adolescents between the ages of 12-18 who were diagnosed with substance use disorder and admitted to the outpatient clinic of university hospital in a city located in the southeastern part of Turkey. Information Form, Internalized Stigma of Mental Disorders Scale-Adolescent Form (ISMI-AF), and Beck Depression Inventory (BDI) were used for data collection.

The mean age of the adolescents was 15.97 years (1.51); 85.9% were male, 59.2% were high school students, and 90.1% had severe depressive symptoms. According to the Pearson correlation analysis, no significant relationship was found between the total scores of the ISMI-AF and BDI; however, BDI, educational status of the adolescent, and academic achievement was found to be statistically significant as determinants of the ISMI-AF (R2=0.29). It was determined that the variables specified in the model explained 24% of the ISMI-AF (Adjusted R Square = 0.24)

Almost all of the adolescents who participated in this study were found to have severe depressive symptoms. In addition to depression, adolescents’ school life and academic achievement were important variables explaining internalized stigma. Since adolescents’ school attendance may be a situation that will prevent substance use, interventions to be carried out in cooperation with mental health professionals and school nurses are very important.

None Declared

The Westernisation of alcohol consumption habits among women has led to increased alcohol intake and a rise in Alcohol Use Disorder (AUD) cases in females. Although AUD prevalence remains higher in men (7.7% compared to 1.5% in women), women display distinct features in the disorder’s progression, such as the telescoping effect, where the transition from initial consumption to dependence occurs more rapidly. This trend underscores the importance of studying frequent female users of alcohol detoxification services to identify contributing factors to this accelerated progression.

This study seeks to characterise frequent female users of alcohol detoxification services, focusing on gender differences, particularly the faster progression of alcohol dependence in women and the influence of Westernisation on their drinking habits.

A retrospective analysis was performed on clinical records from 2022 to 2023 for patients hospitalised at the Alcohol Treatment and Rehabilitation Unit. The analysis included patients who were hospitalised two or more times within a 12-month period. Demographic, psychosocial, and clinical variables were compared, with a particular focus on female patients.

Of the 360 patients admitted between 2022 and 2023, 37 were readmitted within 12 months. Women constituted 29.7% of these cases, with an average age of 52 years (compared to 51 in men), and were more often divorced or separated (81.8% vs 76.9%) and unemployed (72.7% vs 69.2%). Psychiatric family history (72.3% vs 65.4%) and psychiatric comorbidities (90.9% vs 61.5%) were more prevalent in women. Women also had a higher total number of hospitalisations (4.09 vs 3.62), although their 12-month readmission rates were similar to men (1.46 vs 1.50).

These findings support the literature on the telescoping effect, evidenced by women’s older age and a similar number of readmissions despite a more precarious social situation and greater psychiatric comorbidities. Notably, although women were a minority among readmissions, their proportion exceeded the expected prevalence rate (30%/70% vs 15%/85%). This highlights the necessity of personalised therapeutic approaches that address the unique factors perpetuating AUD in women.

None Declared

Chronic pain is a debilitating condition affecting 20% to 30% of adults globally, with prevalence rates rising to 19% to 38% in Europe. It is often linked to self-medication, particularly through alcohol consumption, due to alcohol’s short-term analgesic properties, which act on the opioid system. However, continued alcohol use for pain relief can lead to alcohol use disorder (AUD), worsening the pain and causing physical and mental health issues.

This study explores the relationship between alcohol use in chronic pain management and the development of AUD through a literature review and a clinical case.

A narrative literature review was conducted using PubMed with the terms “alcohol use disorder” and “chronic pain.” English and Portuguese articles from the last 10 years were included, yielding 85 results. A clinical case involving a patient with chronic pain and alcohol dependence illustrates the issue.

The review shows that 28% to 35% of chronic pain patients use alcohol for symptomatic relief. While alcohol may provide initial pain relief, prolonged use leads to tolerance, increased consumption, and a significant risk of AUD. Approximately 18% to 25% of patients meet the criteria for AUD, with men being more commonly affected.

The clinical case describes a 56-year-old man with family history of AUD, who developed chronic pain after a work accident resulting in multiple trauma. The patient began consuming alcohol daily for pain relief, which escalated to an AUD diagnosis and worsened pain due to alcohol-induced hyperalgesia.

Alcohol use is prevalent among chronic pain patients, often as a form of self-medication. However, this practice is frequently counterproductive, as increased consumption to counteract tolerance can lead to serious complications, including hyperalgesia, psychiatric disorders, and significant difficulties in managing both pain and alcohol use disorder (AUD). The clinical case highlights these issues and reinforces the need for a multidisciplinary approach that addresses both pain management and alcohol dependence.

Early detection of problematic alcohol use is essential to prevent the development of AUD. A comprehensive treatment plan, incorporating strategies for pain control and addiction management, is crucial for improving the overall health and well-being of patients dealing with chronic pain.

None Declared

The Greek National Observatory for Internet and Gaming Addiction (NOIAD) is a state-sponsored organization that will be setup in the University of Thessaly during this year following its inclusion in the Greek National Health Plan for Mental Health 2021-2030.

In this presentation of the setup and goals of NOIAD, a case will be brought forward for scientific collaboration across the European continent that could culminate in similar centers in different countries.

The main publication that NOIAD intends to produce annually will have the role of a national report or at least an update of the national situation. In addition to this report, the observatory is expected to prepare a number of studies or reports on individual problems or in response to questions from state institutions (eg Parliament, ministries). Implementation of an online platform (portal) of specialized but also popular knowledge that will aim to inform health professionals and the general population (parents, pupils/students, adults with an addiction problem) with different information profiles for each population. Information lectures, educational activities for minor students, organization of an annual interdisciplinary conference.

NOIAD’s principal goal is the planning and implementation of actions to address digital addictions through the collection of objective, reliable and valid information about the state of Internet and Gaming addiction prevalence and related research and clinical practice in Greece. NOIAD will provide a state-of-the-nation annual report and disseminate the relevant information and conclusions to health professionals, government bodies and the wider population. Furthermore, NOIAD will plan and provide local preventative actions in the wider area of Thessaly, especially regarding the high-school and university student population; these actions will serve as blueprints for similar activities across Greece.

Setting up a national center to provide with a complete picture of Internet Addiction and Gaming Disorder, pool together research output and coordinate preventative actions will assist with a fragmented research landscape and make better use of limited resources.

None Declared

Sex work and transactional sex (SWTS), along with Chemsex, are linked to high-risk sexual behaviors and poorer health outcomes. Chemsex is the use of methamphetamine, GHB/GBL and mephedrone in a sexual context especially among men who have sex with men (MSM). Transactional sex (TS) is the exchange of sexual services for other services or things in a non professional way. Sexwork (SW) means having sex with people in exchange for money in a professional way.

The aim of our study was to determine the prevalence rates of sex work and transactional sex (SWTS) among chemsex users and to answer the question of whether the combination of the two leads to an increased risk profile of those affected in terms of sexual health.

To achieve this, we conducted an online survey across three European German-speaking countries, targeting MSM. The survey gathered data on participants’ substance use patterns, sexual behaviors, and health outcomes, with a particular focus on their engagement in SWTS. SWTS was defined as the exchange of sexual favors for money, drugs, or other material goods, which has been shown to be associated with higher risk behaviors, including unprotected sex and multiple sexual partners.

A total of 399 sexually active MSM were included, categorized into three sub-groups: 129 engaging in Chemsex (MSM-CX), 128 in sexualized substance use with non-Chemsex substances (MSM-SSU), and 142 not engaging in sexualized substance use (MSM-NSU). MSM-CX reported significantly higher rates of SWTS compared to both MSM-SSU (p=.032) and MSM-NSU (p<.001), indicating that Chemsex use is strongly linked to transactional sex. Both Chemsex and SWTS were associated with higher HIV (p<.001, p=.042) and STI (p<.001, p=.023) prevalence, but no cumulative effect was found. Among MSM-CX engaging in SWTS, participants were younger (p=.006), had more sexual partners (p=.029), and reported higher substance use, including methamphetamine, mephedrone, and GHB/GBL. These factors may contribute to the increased vulnerability to HIV and STIs.

The results highlight the need for targeted prevention and intervention measures addressing the risks of Chemsex and SWTS among MSM. Public health campaigns should consider the socio-behavioral traits of Chemsex users, such as their younger age, higher number of sexual partners, and frequent substance use. These efforts should also reduce stigma, encourage help-seeking, and promote safer sex practices. Prevention should focus on regular HIV/STI testing and accessible harm reduction strategies. In conclusion, this study underscores the importance of tailored, evidence-based interventions to improve health outcomes for MSM-CX engaging in Chemsex and SWTS.

None Declared

In recent years, the rise of streaming platforms has given adolescents unprecedented access to vast libraries of series and films, often leading to hours of continuous viewing, a phenomenon known as binge watching. This emerging trend is reshaping how adolescents engage with media, often affecting their social behaviors, routines, and overall well-being. Understanding these factors is crucial for developing preventive interventions.

This study aims to explore binge-watching behavior among Tunisian adolescents and the key factors influencing this trend.

We conducted a descriptive and analytical cross-sectional study among Tunisian adolescents aged between 12 to 18 years old. Data were collected using an online questionnaire spread throughout social media (Facebook), using the Google Forms® platform in September 2024. We evaluated the epidemiological and social characteristics of the participants, as well as the binge watching behaviour, using Binge-Watching Addiction Questionnaire (BWAQ).

Eighty-two adolescents participated in our study, with a mean age of 16.02 ± 1.65 years and a sex ratio of 0.82. Our resultas showed that 86.5% of our population lived in urban areas, 13.4% in rural areas, and 18.3% did not live with both parents. Our results showed that 15.9% of our population reported low grades, 23.2% had repeated a grade, and 27.7% had issues with teachers or administration. Additionally, 21.5% had experienced bullying, 30.5% faced domestic violence, and 31.7% reported conflicts with parents. Regarding binge-watching, 41.5% of participants engaged in it more than once per week, 43.1% spent over two hours daily on school days, and 29.3% watched more than five episodes in one sitting. The most preferred content included drama series (56.1%), movies (24.4%), and sports shows (19.6%).The mean score on the Binge-Watching Addiction Questionnaire (BWAQ) was 39.43, with 27.7% showing moderate and 7.7% showing highly problematic binge-watching, with no sex difference. Highly problematic binge-watching was significantly associated with conflicts with parents (p = 0.01), peers (p = 0.02), school staff (p = 0.42), and poor academic performance, including grade repetition (p < 0.01).

These results highlight the potential negative impact of excessive media consumption on adolescents’ social interactions and and academic performance, underscoring the need to implement targeted interventions that not only raise awareness about the risks of excessive media consumption but also provide practical strategies to help adolescents manage their screen time.

None Declared

Increased levels of anxiety in patients with opioid dependence is a common problem that requires a comprehensive approach to treatment. They can manifest as GAD, panic attacks, social anxiety, and other forms of anxiety. The level of personal distress in patients on methadone therapy can be significant, as these patients often face a complex of psychological and social problems related to addiction and treatment.

The causes of anxiety disorders can be: 1) biological factors - changes in the neurochemistry of the brain associated with the use of opioids, which can affect the regulation of emotions and cause anxiety; 2) psychological factors – trauma in the anamnesis, stressful situations or negative experiences can contribute to the development of anxiety disorders; 3) social factors – relationship problems, social isolation and economic hardship can increase anxiety.

Factors affecting the level of personal anxiety include both medical and social aspects - a) changes in life; b) concomitant mental disorders; c) attitude toward therapy; d) social support.

In the course of the study, 150 patients aged 26 to 64 years with a diagnosis of opioid dependence, who receive methadone hydrochloride as OAMT, were examined. The Psychopathological Symptom Severity Questionnaire (SCL-90-R, Derogatis, Lipman, Covi) and the Hamilton Anxiety Rating Scale (HAM-A/HARS) were used to assess the level of personal anxiety and existing anxiety disorders.

According to the levels of interpersonal anxiety (very low, low, medium, high), the indicators were distributed as follows: in the control group - 10 (20.4%), 32 (65.3%), 7 (14.3%), 0 (0 .0%); in the main group - 28 (27.7%), 59 (58.4%), 13 (12.9%), 1 (1.0%), respectively (p=0.685).

The degree of clinical anxiety according to the Hamilton scale (mild, moderate, severe, strong) in the main group was distributed as follows: 60 (59.41%), 23 (22.77%), 15 (14.85%) and 3 (2.97%); in the control group - 31 (63.27%), 10 (20.41%), 6 (12.24%), 2 (4.08%), respectively (p=0.930).

The level of anxiety according to the SCL-90 scale (very low, low, medium, elevated, high) was determined in 19 (38.78%), 22 (44.90%), 6 (12.24%), 2 (4.08%) and 0 (0.00 %) of persons, respectively, in the control group; 39 (38.61%), 46 (45.54%), 15 (14.85%), 1 (0.99%) and 0 (0.00%) - in the primary (p=0.628).

The results of the study showed that receiving substitution maintenance therapy did not significantly increase the level of personal anxiety and the risk of anxiety disorders in patients on methadone therapy, the vast majority of patients showed very low, low and mild levels of manifestations. However, the level of personal anxiety may vary, but it is important to provide a comprehensive approach to treatment, including psychological support and social integration, to improve patients’ quality of life and reduce anxiety.

None Declared

Nowadays, gambling has become a common form of entertainment for many young people. Gambling is essentially divided into dice games, card games (especially poker), casino games, sports betting, lotteries and, in recent years, online gambling. As a result, gambling has become a major international business, especially among young students.

Evaluate the practice of gambling in a population of young students and describe its characteristics.

We conducted a descriptive and analytical cross-sectional study among university students.

This survey involved a population of Tunisian students recruited through students’ Facebook groups.

A questionnaire was designed to collect information related to participants’ background characteristics and gambling-related details.

DSM-5 criteria were used to screen for pathological gamblers.

A total of 151 students responded to our questionnaire. Gambling was found in 29.1% of the students in our study (n=44).

Thirty players (68.4%) were occasional players. The lottery (54.5%), followed by sports betting (29.5%) and blackjack (27.3%) were the most reported gambling games by students.

Among the players, nineteen (43.2%) experienced a Big Win. The average amount of money spent on gambling per month was 107.14 ± 123.58 TND, with extremes of 4 and 600 TND.

The majority (77.3%; N=34) played online. Among players, 61.4% (N=27) were used to play with friends.

Almost the half of gamblers (45.5%) have started gambling for less than a year and 6.8% have been gambling for 4 to 5 years.

Pathological gamblers represented 13.9% (n=21) of the students in our population.

Our study highlights the prevalence and characteristics of gambling among university students in Tunisia. With nearly 30% of participants engaging in various forms of gambling. These findings suggest a need for targeted awareness and prevention strategies to address potential risks associated with gambling among young adults, particularly in educational settings. Further researches are essential to explore the long-term implications of gambling behaviors on student well-being and academic performance.

None Declared

Exercise addiction (EA) is conceptualized as the uncontrolled practice of physical activity, with repetition of that behavior despite the negative effects on the individual [Khazaal et al. Rev Med Suisse. 2024; 20(882):1354-1359]. According to current systems, EA is included in the group of behavioral addictions [Martyniak et al. Psychiatr Pol 2021;55(6):1357-1372]. The prevalence of EA is understudies, with data from athlete samples ranging from 5-17% [Weinstein et al. Dialogues Clin Neurosci. 2023; 25(1): 1–13]. No prior studies investigatedthe links between chronotype and EA.

This work aimed to assess the relationship between EA and chronotype.

This is a preliminary analysis of data from a larger online survey that assessed the links between behavioral addictions and psychopathology in an online community sample. The inclusion criteria were 1) age ≥18-35 and 2) consent to participate. A local bioethical committee approved the study. Responders completed self-report questionnaires to assess EA: EAI (Exercise Addiction Inventory-Short Form), and chronotype Composite Scale of Morningness (CSM). The participants were divided into subgroups based on their EAI scores: 1) with negative EA screen (EA [-]) [scores ≤12], 2) with positive EA screen (EA [+]) [scores >12]. EA[-] and EA [+] were compared in terms of general characteristics and chronotype (continuous measure). The quantitative data were evaluated with a T-test. The qualitative data were analyzed using the Χ2 test.

183 subjects were EA [-] and 99 were EA [+]. There were no significant differences between the groups regarding the mean age: EA [-] 27.36±10.74 years; EA [+] 25,55±7.47 years [t (2, 262) =1.661, p< 0.09]. EA [+] were more likely to be male (40.4%) than EA [-] (27.3%) (Χ2=5.060, df=1, p=0.026). There were no differences in the levels of education (primary/secondary/ college student/ university student/ completed higher education) in the studied groups (Χ2=1.78, df=4, p=0.786). EA [+] showed a higher level of morningness measured with the CSM total score (34.13±6.48) than EA [-] (30.62±8.63)[t (2, 251.8) = 3.855, p< 0.001).

EA was linked to male sex in the studied sample. Individuals with positive exercise addiction screen present higher levels of morningness.

None Declared

Behavioral addiction is well-established for gambling but still debatable for other pleasurable behaviors such as eating. Attachment style is defined as a psychological concept describing the dynamics of human interpersonal interactions. Studies investigating the influence of attachment style on food addiction are rare.

The aim of the study was to evaluate the association between food addiction and the quality of attachment

A cross-sectional study was conducted online with a non-clinical population. All participants completed an anonymous e-questionnaire containing sociodemographic data, background, substance use and self-reported weight and height. Attachment style was assessed with the Relationship Scale Questionnaire (RSQ). Food addiction was screened with modified Yale food addiction scale questionnaire (mYFAS 2.0).

A total of 114 individuals had fully responded to the questionnaire. The mean age was 32.28 ± 9.32 years with a sex ratio of 0.48. The mean BMI was 23.7 kg/m2 ± 5.5. Most of participants (64%) had an insecure attachment style and 36% had a secure one. The results of the mYFAS 2.0 showed that 11.4% of participants had a food addiction and 8.8% had a severe form. BMI was significantly associated with food addiction which was more common in participants who had a BMI greater than 22.2 kg/m2. A statically significant association between insecure attachment style and food addiction was found.

Our study showed the importance of studying attachment style in food addiction. More research is needed to prove the association between food addiction and different attachment styles.

None Declared

Alcohol withdrawal syndrome (AWS) is among the most severe components of alcohol dependence (AD). Severe AWS, especially complicated with seizures and delirium, was a common reason for medical complications and death. The introduction of benzodiazepines decreased but did not eliminate those risks. The definition of AWS evolved in different versions of Diagnostic and Statistical Manual for Mental Disorders (DSM) from having hand tremor plus one or more other symptoms in DSM-III-R to any two or more symptoms in DSM-IV, which was retained in the current version of DSM-5.

Comparing subgroups of individuals with AUD based on AWS symptoms profile to define phenotypes for investigation of biological underpinnings of AWS phenomenology and treatment response.

Treatment-seeking individuals diagnosed with DSM-IV alcohol dependence (AD; n=473; 35.5% females) were assessed with Psychiatric Research Interview for Substance and Mental Disorders (PRISM), Timeline Follow back (past 90 days) alcohol consumption, Penn Alcohol Craving Scale (PACS), Pittsburgh Sleep Quality Index (PSQI), Patient Health Questionnaire-9 (PHQ9), and General Anxiety Disorder-7 (GAD-7). Latent class analysis was used to classify subjects according to lifetime prevalence of AWS symptoms according to DSM-III-R or DSM-IV/5. Demographic and other clinical variables were compared among clusters by linear model ANOVA and chi-squared test.

Four clusters were identified: subjects with (1) no history of meeting any AWS criteria (n=50); (4) with complete number of AWS symptoms, meeting both DSM definitions (n=259); and two clusters of subjects with smaller number of AWS symptoms: (3) those meeting only DSM-IV/5 criteria (n=94) and (2) those also meeting DSM-III-R criteria (n=70). Compared to cluster 2, the Cluster 3 members had higher frequency of anxiety, insomnia, and restlessness during withdrawal. The clusters also differed in the total number of drinks (p=0.021), average drinks per drinking days (p=0.013), history of anxiety disorder (p=0.006), substance-induced depression (p=0.019), and higher scores of PSQI (p<0.001), PHQ9 (p<0.001), and GAD-7 (p<0.001) with a relative increase in frequency between clusters as follows 1<2<3<4. Group 4 also had the highest percentages of subjects with history of seizure, delirium or hallucinations.

Different definitions of AWS capture clusters of AD patients with different symptomatology, comorbidity and consumption patterns. Understanding of biological underpinnings behind those differences may guide improvement in personalized treatment selection.

None Declared

IIn recent decades, the global rise in obesity and related diseases has led researchers to investigate factors like ultra-processed foods (UPF), known for promoting overconsumption due to their low cost and hyper-palatable design. Studies link UPF to obesity, cardiovascular diseases, and type 2 diabetes, while the concept of food addiction to UPF has emerged to explain compulsive eating. Although not yet officially recognized, UPF addiction calls for urgent public health strategies to regulate their production and consumption.

We aim to assess addiction to ultra-processed foods in the general population, its effects on mental and physical health, and explore the factors influencing these eating behaviors to propose intervention approaches for preventing and treating this form of addiction.

A questionnaire assessed ultra-processed food addiction in the general population, along with its health effects and factors influencing this behavior. A multivariate analysis, including a logistic regression model, measured the impact of different variables on this addiction.

Using the YFAS 2.0 scale, 16.2% of participants show dependence on ultra-processed foods, mostly in mild to moderate forms. Logistic regression reveals that addiction is associated with being female, overweight or obese, and having low perceived well-being, increasing the risk by 6.8, 4.9, and 7.6 times, respectively. These findings suggest that food addiction is influenced by both biological (e.g., BMI) and psychological (e.g., well-being) factors.

The literature shows that addiction to ultra-processed foods, though not officially recognized, is associated with overconsumption behaviors and various health issues, including obesity and cardiovascular diseases. These foods, designed to be highly palatable, activate the brain’s reward circuits. Public health strategies, such as regulation and labeling, are essential to prevent negative health impacts.

None Declared

Alcohol Use Disorder (AUD) and its comorbidities can have a tremendous negative impact on various activities of daily living, including the capability to manage one’s finances. Adequate financial functioning is essential for an individual’s health and well-being and is key to leading an autonomous and independent life. Problems with financial functioning can have far-reaching personal and legal consequences, and may lead to financial insecurity or poverty, financial victimisation, placement under guardianship, and reduced opportunities for social and societal participation.

To evaluate the financial situation and the strengths and weaknesses in the everyday financial functioning of individuals with AUD.

The financial situation and financial performance of an AUD group (n = 52) were compared to a control group (CG) (n = 95), using the Financial Performance Scale (FiPS). In addition, associations between financial performance and everyday contextual factors (i.e., income, depressive symptoms (i.e., Beck Depression Scale - II), social support (i.e., Brief Perceived Social Support Questionnaire)) were explored.

As compared to the CG, the AUD group reported to have a significantly poorer financial situation, including lower income levels, more frequent debts, and fewer savings. Furthermore, the AUD group reported a significantly poorer overall financial performance (FiPS total score) than the CG, and significant group differences were observed for relatively complex financial tasks, such as financial goal setting and doing tax returns. The difficulties in financial performance of the AUD group were, however, considered as relatively mild, since most aspects of financial performance (i.e., FiPS item scores) did not differ between groups. In the total sample, a better financial performance was significantly associated with a higher income, more perceived social support, and fewer depressive symptoms.

Individuals with AUD reported a poorer financial situation and more difficulties with performing complex financial tasks compared to controls. These reported weaknesses may stem from cognitive and affective impairments associated with AUD, as well as from a scarcity of financial resources. Since a vicious cycle may exist between financial problems and AUD symptoms, it is relevant to enhance the financial well-being of those individuals with AUD who experience financial difficulties.

None Declared

The use of anxiolytics is a complex phenomenon, increasingly affecting the student population. Inappropriate use of this type of treatment can lead to abuse and even dependence.

To study the prevalence of dependence on anxiolytics, particularly benzodiazepines BZD in this population and to identify its associated factors.

This was a cross-sectional descriptive study carried out among students from Gabes institute of nursing sciences, for a period of two months(March to May 2024).

Data were collected using an online anonymous questionnaire from Google form that we distributed via Messenger social network.

We used the Benzodiazepine Attachment Cognitive Scale (BACS) to study BZD dependence.

A score ≥ 6 enables to differentiate between dependent and non-dependent patients.

We collected data from 135 students. Our sample included only 33 students.

The mean age of our population was 21.30 ±1.51 years and the sex ratio (M/F) was 0.65.

Consumption of psychoactive substances (PAS) was reported by 21 students (63.63%): tobacco by 21.2%, coffee by 12.2% and alcohol by 12.2%.

All students reported having taken benzodiazepines BZD.

In our study, 13 students (39.4%)reported having used BZDs 1 or 2 times in their lives (for experimental purposes). Daily use of BZDs was not reported.

The mean score of the ECAB scale was 6.93, with extremes of[3-10].

According to our results, dependence on BZD was clearly predominant, found in 28 students (84.8%). No correlation was found between the socio-demographic characteristics and the presence of anxiolytic dependence.

BZD dependence (assessed by the ECAB scale) was correlated with coffee consumption (p=0.03), unlike for other substances (tobacco, alcohol, cannabis).

The study highlighted the high level of dependence on anxiolytics, particularly BZD and identified individuals who were at higher risk. Specific interventions were necessary to deal with the problem of addiction.

None Declared

Access to university marks a crucial stage in the lives of young adults. This transition can generate high levels of stress and anxiety, influencing their mental and emotional well-being.

To overcome these challenges, some students may resort to the increasingly common use of psychotropic drugs, particularly anxiolytics, to ease their distress.

To determine the relationship between anxiolytic dependence, anxiety and depression in students.

This was a cross-sectional, descriptive and analytical study conducted on Gabes institute of nursing sciences, for a period of two months(March to May 2024).

We used:

• - Benzodiazepine Attachment Cognitive Scale (BACS) : to study BZD dependence.

  A score above 6 indicates dependance to BZD.

• - Hospital and anxiety depression scale (HAD): to assess the severity of anxiety and depressive symptoms. Seven questions relate to anxiety (total A) and seven to depression (total D), giving two scores (maximum score for each = 21).

The sample comprised 33 students. The mean age of our population was 21.30 ±1.51 years and the sex ratio (M/F) was 0.65.

The mean score of the ECAB scale was 6.93, with extremes of [3-10].

According to our results, dependence on BZDs was clearly predominant, found in 28 students (84.8%).

According to the HAD scale, 82% of students showed anxiety symptoms and 24.2% were depressed.

According to our study, we found that BZD dependence in students was strongly correlated with anxiety with p=0.007.

Similarly, we found that those dependent on BZDs were more likely to develop depressive symptoms compared with non-dependents, with a significant difference (p=0.04).

Our findings suggest that the greater the dependence on anxiolytics, the greater the risk of developing anxiety and depressive symptoms.

None Declared

Nicotine replacement therapy, particularly nicotine gum, is an effective tool for smoking cessation but may lead to dependence in 6-9% of long-term users. This report presents two patients with prolonged nicotine gum dependence, exploring individualized treatment strategies and their outcomes.

To evaluate two personalized treatments for nicotine gum dependence: one using transdermal nicotine patches with psychosocial support, and the other using bupropion with psychosocial support.

Patient A, a 67-year-old retired technician with a history of anxiety, depression, and past alcohol and benzodiazepine dependence (both in remission), began smoking at 16 (20 cigarettes a day) and quit at 35 due to Leriche Syndrome, switching to 20 pieces of 2 mg nicotine gum daily. In a four-week program, he transitioned to nicotine patches with a gradual dose reduction, alongside psychosocial support. Patient B, a 61-year-old social worker with a history of depression, smoked 40 cigarettes daily until quitting at 51 due to COPD, then developed a long-term dependence on 30 pieces of 4 mg gum. Fifteen days before admission, she abruptly discontinued using nicotine gum. She presented to the program seeking support and strategies for managing cravings, and her treatment focused on psychosocial interventions and medication adjustments.

Both patients successfully achieved abstinence and improved functioning. Patient A transitioned from nicotine gum to nicotine patches, starting at 40 mg daily, reducing to 25 mg after six weeks, and then to 15 mg before discontinuation. Throughout the treatment period, the patient successfully maintained abstinence. Psychological assessments showed stable mood and satisfactory remission. One week into the treatment, patient B reported difficulties in maintaining abstinence after abruptly stopping nicotine gum during a COVID-19 infection. She began experiencing increased depressive symptoms and nervousness, leading to an increase in bupropion (which she used prior to enrolling in the program) dose from 150 mg to 300 mg daily. Active participation in group therapy helped her manage cravings and control anxiety, preventing relapse.

Two distinct approaches, one using nicotine patches and the other pharmacological support, both highlighted the importance of psychosocial support in achieving nicotine gum dependence cessation. Nicotine patches, with their slower absorption, are less rewarding and reduce long-term dependence risk. Despite patient B’s initial struggles after abrupt cessation, the combination of increased bupropion and active therapy participation helped manage cravings and anxiety. Both cases highlight the importance of individualized care and comprehensive psychosocial interventions for sustained nicotine abstinence.

None Declared

Abstinence is crucial in the rehabilitation of alcohol-dependent (AD) patients, yet relapse rates remain high. Despite extensive research on relapse predictors, various sociodemographic and medical factors are still overlooked. The COVID-19 pandemic has presented numerous challenges in preserving mental health, but little is known about how recovery from symptomatic COVID-19 impacts relapse in AD patients.

To examine the associations and differences in sociodemographic, medical, and COVID-19 factors between AD patients who relapsed and those who maintained abstinence. We assessed changes in these differences over time at two assessment points.

This study, part of a larger project on COVID-19 recovery and psychiatric symptoms in AD patients, runs from March 2023 to March 2025 with assessments at inclusion and after six months. Eighty treatment-seeking AD patients, without severe comorbid mental illness or other substance use, are included. Data cover sociodemographic and medical info, COVID-19 recovery details (number of episodes, time since last episode, treatment, vaccination, symptoms), and AD history (age of drinking onset, binge onset, age at first treatment, alcohol-related issues, commonly consumed type of alcohol, liver disease presence, abstinence duration, and relapse status at the second assessment). The Alcohol Use Disorders Identification Test (AUDIT), CAGE questionnaire for alcohol screening, and Alcohol Timeline Follow Back (TLFB) are used to assess relapse severity. A two-way repeated-measures ANOVA was used to examine sociodemographic, medical, and COVID-19 factor differences between patients who relapsed and those who did not.

Preliminary data indicate differences in occupational and marital status, psychiatric and physical comorbidities, inpatient AD treatment, regular drinking patterns, alcohol-related data, heavy liquor consumption, age of excessive drinking, and prior hospitalizations between patients who relapsed and those who did not. Some variable changes over time were also noted in both groups.

Differences in multiple sociodemographic and medical factors between relapsed and non-relapsed AD patients should be addressed in AD treatment. COVID-related factors show no strong association with relapse, likely due to mild disease forms in most participants.

None Declared