Inflammation, Sickness Behaviour and Depression

doi:10.1017/9781108539623.008

Chapter 7 - Inflammation, Sickness Behaviour and Depression

Published online by Cambridge University Press: 02 September 2021

Golam Khandaker ,

Alessandro Colasanti and

Edited by

Edward Bullmore and

Golam Khandaker: Affiliation:
University of Cambridge
Neil Harrison: Affiliation:
Cardiff University Brain Research Imaging Centre (CUBRIC)
Edward Bullmore: Affiliation:
University of Cambridge
Robert Dantzer: Affiliation:
University of Texas, MD Anderson Cancer Center

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Summary

The association between infections and changes in mood, motivation and cognition including induction of lethargy, irritability, impaired concentration and memory, lowering of mood, decreased social activity, anhedonia and somnolence has been known for centuries (1). However, it was only in the late 1980s when it was realized that these behavioural changes are the same regardless of the infecting organism (2; 3), and that sickness behaviours represent a critical component of the host response to infection. Indeed, it is now clear that pro-inflammatory cytokines such as interleukin (IL)-1 and tumour necrosis factor-α (TNF-α) that play a central role in coordinating peripheral immune response also play a critical role in triggering systemic responses to infection including fever and sickness behaviours through direct and indirect actions on the brain (4).

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Type: Chapter
Information: Textbook of Immunopsychiatry , pp. 109 - 138

DOI: https://doi.org/10.1017/9781108539623.008 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2021

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