To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge-org.demo.remotlog.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Based on promising preliminary results from clinical trials, it seems likely that psychedelic substances (classic serotonergic psychedelics, such as psilocybin, and entactogens, such as MDMA) will be introduced into psychiatry as psychedelic-assisted therapy. This also raises a range of ethical questions that urgently need to be addressed before widespread roll-out in society. This scoping review fills a gap in the literature by providing an overview of these ethical issues using a systematic search, presentation, and descriptive analysis of ethical issues in psychedelic-assisted treatments. It includes peer-reviewed studies pertaining to human study participants and psychiatric patients (population), which discuss ethical issues (concept) of psychedelic treatments (context) in clinical trials and other clinical applications. The systematic search included several databases: MEDLINE, PsycInfo, CINAHL, HeinOnline, and PsycArticles. The search strategy, including all identified keywords and index terms, was adapted for each included database. The search was completed in June 2025 and studies published until then in any language were included. After an iterative process of inductive and deductive coding of ethical issues, the scoping review comprises seven themes related to the ethics of psychedelic-assisted treatments: (1) safety and patient well-being, (2) therapeutic relationships, (3) informed consent, (4) equity and access, (5) research ethics, (6) special contexts, and (7) societal and cultural implications. The results can be used to inform and stimulate further discussion and in-depth research on the ethics of psychedelic-assisted treatments, possibly leading to more nuanced debate surrounding a safer and more ethical implementation of psychedelic-assisted treatments in the future.
This revision guide is an invaluable resource for psychiatric trainees preparing for exams. With 55 case vignettes and over 200 topical multiple-choice questions (MCQs), the content covers a broad spectrum of relevant psychiatric disorders, including schizophrenia, anorexia nervosa, addiction, and gender dysphoria. Case vignettes provide a focused discussion of each disorder, while strategically placed topical MCQs consolidate learning and highlight concepts across disorders. Recurring features are included at the end of each chapter, including 'Exam Essentials,' which highlight the most crucial information students should remember, 'Clinical Pearls', which provide tips for practical application, and the 'Diving Deep' section allows interested students to explore specific concepts further. An engaging and comprehensive revision resource, this will be a go-to resource for MRCPsych candidates and those taking specialist examinations.
This study explores psychiatrists’ perceptions of Attention-Deficit Hyperactivity Disorder (ADHD) through the lens of evolutionary psychiatry, a growing field that reframes mental disorders in the context of adaptation and survival. Evolutionary theories suggest that traits associated with ADHD, such as impulsivity, hypercuriosity and novelty-seeking, may have been adaptive in ancestral environments, though they manifest as maladaptive in structured modern contexts.
Method:
A bespoke 10-item questionnaire was developed to assess psychiatrists’ attitudes following a presentation on evolutionary perspectives of ADHD by an expert. The questionnaire allowed rating in 5-point Likert fashion and was followed by a free text box for qualitative analysis. Basic descriptive statistics and One-Way ANOVA pairwise comparisons between groups was used to test for statistical significance. A p value of <0.05 was deemed statistically significant.
Results:
Forty-two participants, including 21 consultants and 19 psychiatry trainees completed the questionnaire. All participants rated their comprehension of the presentation as high/very high. Most strongly agreed that the information presented could improve psychiatry and therapeutic outcomes. However, consultants with more than 10 years of experience were less likely than trainees to report optimism about the practical applications of evolutionary frameworks. Qualitative feedback emphasized the relevance of evolutionary perspectives in clinical practice, particularly in reducing stigma and enhancing therapeutic engagement with patients and families.
Conclusions:
While the results from this study were positive, limitations include the small sample size and lack of prepresentation baseline data. However, this study has formed part of the first step in investigating the perceptions and attitudes of psychiatrists on evolutionary perspectives on ADHD.
Psychiatric advance directives (PADs) are documents enabling individuals with mental health conditions to specify their treatment preferences for future mental health crises. Despite the benefits of PADs, their implementation has progressed slowly. Concerns about PADs among professionals seem to be part of the explanation. A commonly reported concern is that service users will use PADs to document extensive treatment refusals. Research has not yet explored professionals’ views on ethical conflicts arising from such refusals.
Objectives:
The objective of this study was to explore professionals’ perspectives on ethical conflicts arising from treatment refusals in legally binding PADs.
Methods:
We carried out semi-structured interviews with 14 mental health professionals working in Germany with professional experience with PADs. We prompted discussions using a case report of an ethical conflict arising from a treatment refusal documented in a PAD. We analyzed the data thematically.
Results:
Professionals described the case as extreme yet not unfamiliar. While many felt obligated to respect the PAD, they also felt inclined to override it to promote service user well-being, restore service user autonomy, and protect others. Those inclined to override the PAD focused on scrutinizing its validity and applicability, raising doubts about information disclosure, voluntariness, decision-making capacity, and PAD irrevocability. Professionals believed ethics consultation would help address the ethical conflict.
Conclusions:
Legally binding PADs can create ethical conflicts when they include treatment refusals. While the best policy response remains unclear, professionals can help prevent such conflicts by supporting service users in drafting PADs.
Over 1% of the world’s population have been forcibly displaced. Asylum seekers and refugees (ASR) are at higher risk of serious mental illnesses. Despite a high need for care, little is known about the attitudes, knowledge and competencies of psychiatrists who may treat ASR subjects.
Aims
The study aimed to identify perceived gaps in psychiatric training that could help guide medical education and policymaking related to treating ASR mental health.
Method
We conducted the first national survey of UK-based psychiatrists to assess attitudes, knowledge and competencies around treating ASR subjects. The online survey was sent to all psychiatrists (N = 18 182) and registered trainees (N = 4700) on the Royal College of Psychiatrists databases in 2022. We used exploratory and confirmatory factor analyses to identify the optimal factor structure underlying the questionnaire. Variations in scores on extracted latent constructs by sociodemographic and clinical variables were explored using linear regression.
Results
Data from 609 psychiatrists (77%) and trainees (22%) were included in the final analysis. We identified four latent constructs concerning perceived knowledge, positive attitudes, negative attitudes and perceived distress. Only 42% of respondents felt they had sufficient knowledge to work competently with ASR subjects, and 34.7% found the work emotionally distressing. Greater knowledge predicted both more positive (β = 0.26, 95% CI: 0.20–0.33) and more negative (β = 0.17, 95% CI: 0.09–0.26) attitudes, and was associated with less self-reported distress among psychiatrists (β = –0.34, 95% CI: –0.43 to –0.21). Female psychiatrists reported more distress related to treating ASR subjects (β = 0.29, 95% CI: 0.14–0.44).
Conclusions
Less than half of psychiatrists in this survey believed they possessed adequate knowledge to treat ASR subjects, and some found working with such individuals distressing. Our results suggest that these issues could be mitigated by improving knowledge related to treating ASR subjects.
Machine learning, an artificial intelligence (AI) approach, provides scope for developing predictive modelling in mental health. The ability of machine learning algorithms to analyse vast amounts of data and make predictions about the onset or course of mental health problems makes this approach a valuable tool in mental health research of the future. The right use of this approach could improve personalisation and precision of medical and non-medical treatment approaches. However, ensuring the availability of large, good-quality data-sets that represent the diversity of the population, along with the need for openness and transparency of the AI approaches, are some of the challenges that need to be overcome. This article provides an overview of current machine learning applications in mental health research, synthesising literature identified through targeted searches of key databases and expert knowledge to examine research developments and emerging applications of AI-enabled predictive modelling in psychiatry. The article appraises both the potential applications and current challenges of AI-based predictive modelling in psychiatric practice and research.
Niall Crumlish (1974 – 2025) was a profoundly compassionate psychiatrist, uniquely gifted music journalist, and cherished husband, father, son, brother, and friend. He embodied humility, kindness, and compassion in all he did. Niall qualified in medicine from University College Dublin (UCD) in 1997; obtained membership of the Royal College of Psychiatrists in 2002; graduated with a Masters degree (MSc) in Transcultural Mental Healthcare from Queen Mary University of London in 2009; and obtained the degree of Doctor of Medicine (MD) from UCD in 2014. During his clinical training, Niall spent 18 months at St John of God Mental Health Services in Mzuzu, Malawi, a country which left a deep impression on him. In 2010, Niall was appointed as Consultant General Adult Psychiatrist at St James’s Hospital, Dublin with the Camac sector where his sense of humour and generosity left a lasting impression on all who worked with him. Niall was an especially gifted writer about music with an unrivalled depth of knowledge and sensibility. He wrote voraciously for Hot Press magazine from 1993 onwards, where his contributions were widely acclaimed. Through his writings in various publications and on his blog ‘Psychiatry and Songs’, Niall created a body of work that is elegant and intelligent, eloquent and heartfelt, intimate and universal.
Clinical placements are essential in healthcare education, offering practical experience and skill development under experienced supervision. However, little research has explored the characteristics of effective psychiatry placements. Understanding the factors considered vital by psychiatry core trainees for a successful placement is crucial amid concerns about trainee attrition in psychiatry programmes.
Aims
This study aims to identify key elements that contribute to a successful psychiatric placement, as perceived by final-year core trainees.
Method
This qualitative study uses one-hour, semi-structured interviews with 15 core trainees in their final placement within the South London and Maudsley Training Programme. Interviews were guided by appreciative inquiry principles, and two independent researchers employed a classic thematic analysis method while maintaining appropriate reflexivity throughout.
Results
A central theme emerges regarding the importance of a well-designed learning environment, which includes a robust training infrastructure, psychological safety, active learning opportunities, access to role models and structured feedback. The supervisor–supervisee relationship is emphasised, with the ideal supervisor being both knowledgeable and empathetic and offering mentorship and pastoral support. These factors are key to professional growth, well-being and job satisfaction, and they are strongly linked to retention in the field.
Conclusion
Core trainees value placements that address foundational training needs and cultivate psychological safety while facilitating experiential learning. Addressing these aspects in training programmes enhances the educational experience and improves retention. Future research should explore supervisors’ perspectives and examine how to balance ideal and practical supervisory roles.
The formative years of childhood and adolescence shape the course of future mental health. The COVID-19 pandemic has been associated with increased mental health problems in young people. This study aimed to examine changes in referrals and clinical activity in a child and adolescent mental health service (CAMHS) in Qatar following the pandemic.
Aims
To explore changes in referral trends and clinical activity in CAMHS, including referral numbers, reasons, sources, demographics, urgency and multidisciplinary team (MDT) allocation, comparing pre-pandemic (2019) with post-pandemic periods (2021, 2022).
Method
A retrospective analysis of referral data from CAMHS was conducted. Data were collected from the administrative paper data archived in the relevant department for the years 2019, 2021 and 2022. Referral data included: source, reason, urgency, patient demographics and outcome. Chi-square analysis was employed to compare referral trends and patient characteristics across the 3 years. Binary logistic regression was used to identify factors associated with urgent referrals.
Results
A significant increase in referrals was observed post-pandemic, with notable changes in referral reasons (increased mood and anxiety disorders), sources (increased referrals from public and private hospitals) and urgency (higher proportion of urgent referrals). MDT allocation shifted towards psychiatrists, with a decrease in joint assessments.
Conclusions
The COVID-19 pandemic had a substantial impact on CAMHS referrals and clinical activity in Qatar. The observed changes highlight the urgent need for additional resources and services. Adapting service delivery models and strengthening collaboration between healthcare sectors are crucial to addressing the evolving mental health needs of children and adolescents effectively.
This chapter invites readers to consider how an engagement with hip-hop music and culture can contribute to a better understanding of mental health, psychiatry, psychology, public health, and neuroscience. It provides an introduction to hip-hop therapy, highlighting the use of rap by psychologists and counsellors to promote mental well-being. The chapter goes on to examine the work that the Hip-Hop Psych initiative has undertaken in advancing the role of hip-hop in primary care. With hip-hop’s pre-eminence as a global musical force, greater attention to how mental health is represented in hip-hop can provide healthcare professionals with tools to aid discussions with patients about potential trends related to hip-hop icons, such as contagion effects of suicide, self-harm, and self-medication. Hip-hop offers a platform for artists and those who embrace the culture to address their emotional experiences through rap. By exploring lyrical content, the chapter uncovers how performers express their mental health challenges and fashion resilience within challenging circumstances. It argues that attention to this material could also help identify language disturbances associated with mental health conditions, and indicates the potential gains from the use of technology and neuroscientific research to support hip-hop music interventions.
Mental ill-health has a major impact on young people, with pain often co-occurring. We estimated the prevalence and impact of pain in young people with mental ill-health.
Methods
Longitudinal data (baseline and three-month follow-up) of 1,107 Australian young people (aged 12–25 years) attending one of five youth mental health services. Multi-level linear mixed models estimated associations between pain characteristics (frequency, intensity, and limitations) and outcomes with false discovery rate (FDR) adjustment. Pain characteristics were baseline-centered to estimate if the baseline score (between-participant effect) and/or change from baseline (within-participant effect) was associated with outcomes.
Results
At baseline, 16% reported serious pain more than 3 days, 51% reported at least moderate pain, and 25% reported pain-related activity limitations in the last week. Between participants, higher serious pain frequency was associated with greater anxiety symptoms (β[95%CI]: 0.90 [0.45, 1.35], FDR-p=0.001), higher pain intensity was associated with greater symptoms of depression (1.50 [0.71, 2.28], FDR-p=0.001), anxiety (1.22 [0.56, 1.89], FDR-p=0.002), and suicidal ideation (3.47 [0.98, 5.96], FDR-p=0.020), and higher pain limitations were associated with greater depressive symptoms (1.13 [0.63, 1.63], FDR-p<0.001). Within participants, increases in pain intensity were associated with increases in tobacco use risk (1.09 [0.48, 1.70], FDR-p=0.002), and increases in pain limitations were associated with increases in depressive symptoms (0.99 [0.54, 1.43], FDR-p<0.001) and decreases in social and occupational functioning (−1.08 [−1.78, −0.38], FDR-p=0.009).
Conclusions
One-in-two young people seeking support for mental ill-health report pain. Youth mental health services should consider integrating pain management.
This article analyses the relationship between Italian feminism and mental health in the 1970s, focusing on Turin. It explores the main theoretical debates that dominated feminist magazines and meetings during those years. In feminist groups and collectives, discussions about women’s wellness and illness began with the broader theme of health and knowledge of one’s body. However, they subsequently expanded to include personal, theoretical, clinical and political issues related to mental health. New experiences such as autocoscienza (consciousness-raising) and the practice of the unconscious allowed feminists to examine the effects of gender roles and models, existential contradictions, distress and intolerance, discomfort with doctors, psychiatric hospitalisation and the shortcomings of territorial services. The case of Turin shows that these experiences paved the way for subsequent interactions between feminism and the psychiatric reform movement.
The integration of computational methods into psychiatry presents profound ethical challenges that extend beyond existing guidelines for AI and healthcare. While precision medicine and digital mental health tools offer transformative potential, they also raise concerns about privacy, algorithmic bias, transparency, and the erosion of clinical judgment. This article introduces the Integrated Ethical Approach for Computational Psychiatry (IEACP) framework, developed through a conceptual synthesis of 83 studies. The framework comprises five procedural stages – Identification, Analysis, Decision-making, Implementation, and Review – each informed by six core ethical values – beneficence, autonomy, justice, privacy, transparency, and scientific integrity. By systematically addressing ethical dilemmas inherent in computational psychiatry, the IEACP provides clinicians, researchers, and policymakers with structured decision-making processes that support patient-centered, culturally sensitive, and equitable AI implementation. Through case studies, we demonstrate framework adaptability to real-world applications, underscoring the necessity of ethical innovation alongside technological progress in psychiatric care.
The premorbid phase of treatment-resistant schizophrenia (TRS) may reveal underlying mechanisms and inform early interventions. According to the neurodevelopmental hypothesis, treatment resistance may be linked to pronounced developmental impairments. We examined school grades and attendance trajectories in children who later developed TRS.
Methods
This case-control study analyzed school grade point average and attendance among all individuals born after 1990 and started on clozapine in Chile’s public health system as a proxy for TRS. Control groups included children later diagnosed with treatment-responsive schizophrenia, bipolar disorder, and unaffected classmates. Linear mixed models accounted for individual and school-level confounders.
Results
We included 1072 children (9929 observations, 29.3% female) subsequently diagnosed with TRS, 323 (2802 observations, 25.7% female) with schizophrenia, 175 (1784 observations, 53.8% female) bipolar disorder, and 273,260 (533,335 observations, 47% female) unaffected classmates. Children who later developed TRS had worse grades across levels than their classmates (−0.26 SD [−0.2, −0.4]), but not treatment-responsive schizophrenia. All severe mental illness groups showed grade declines in later school levels, with TRS showing steeper linear decline than treatment-responsive schizophrenia (group×age of −0.03; 95%CI −0.04, −0.01) and steeper quadratic decline than bipolar disorder (group×age2 of −0.005; −0.01, −0.001). Attendance declined over time in the two groups developing schizophrenia compared to their classmates. Those developing TRS experienced the sharpest drop (group×age compared to schizophrenia −0.03; −0.05, −0.01 and bipolar disorder −0.027; −0.049, −0.006).
Conclusions
TRS may stem from a more aggressive pathological process or pronounced late-maturation abnormality, rather than an early premorbid impairment, suggesting an intervention target.
This review article explores the legislative differences across Canadian jurisdictions with respect to involuntary admission and treatment pending appeal. Some jurisdictions restrict involuntary admission for mental illness to when there is a risk for serious bodily harm or physical impairment. However, the majority of jurisdictions recognize non-bodily harms or substantial mental or physical deterioration as grounds for involuntary admission when other criteria are met. Once a person is involuntarily admitted, jurisdictions differ on how treatment is authorized and whether treatment can commence while a person contests a finding of incapacity to treatment to the courts. Some jurisdictions permit treatment pending appeal while others do not. This article compares Canadian jurisdictions’ mental health legislation and addresses discrepancies through the lens of the Canadian Charter of Rights and Freedoms and the Canada Health Act.
To investigate levels of knowledge and attitudes towards advance healthcare directives among inpatient psychiatry service users in Ireland.
Methods:
A survey was completed among adult inpatient psychiatry service users (n = 47) in Tallaght University Hospital, Dublin.
Results:
Just over one in ten (11%) inpatient psychiatry service users had heard of advance healthcare directives. None had created an advance healthcare directive, but over a quarter (25.5%) had written down or verbally told someone what they would like to happen when they became unwell. When asked ‘if you were supported by your healthcare provider to make an advance healthcare directive, would you like to make one?’, over two thirds responded either ‘definitely yes’ (34%) or ‘probably yes’ (34%). On multi-variable testing, future willingness to make an advance healthcare directive was significantly associated with younger age but not with ethnicity, gender, education, employment status, or prior knowledge of advance healthcare directives. All respondents would involve someone else in making an advance healthcare directive. There was high confidence that healthcare practitioners would respect an advance healthcare directive (87%).
Conclusions:
There are high levels of interest in advance healthcare directives, but low levels of knowledge and use among inpatient psychiatry service users in Ireland. Our findings indicate a need for educational initiatives and resources to increase awareness. Such efforts could usefully focus especially on appropriate use of advance healthcare directives in psychiatric care and seek to bridge the gaps between evidence of benefit, legislative reform, and their use in mental healthcare.
There is growing evidence that smoking increases the risk of developing psychiatric disorders, but the underlying mechanisms are largely unknown. We examine brain structure as a potential pathway between smoking and psychiatric disease liability.
Methods
We test associations between smoking (initiation, cigarettes per day, cessation, lifetime use) and depression, bipolar disorder, and schizophrenia, with and without correcting for volume of the amygdala, hippocampus, lateral and medial orbitofrontal cortex, superior frontal context, and cortical thickness and surface area. We use three methods that use summary statistics of genome-wide association studies to investigate genome-wide and local genetic overlap (genomic structural equation modeling, local analysis of (co)variant association), as well as causal associations (Mendelian randomization).
Results
While we find causal effects of smoking on brain volume in different brain areas, and with psychiatric disorders, brain volume did not seem to mediate the effect of smoking on psychiatric disorders.
Conclusions
While these findings are limited by characteristics of the included summary statistics (e.g. sample size), we conclude that brain volume of these areas is unlikely to explain a substantial part of any effect of smoking on psychiatric disorders. Nevertheless, genetic methods are valuable tools for exploring other potential mechanisms, such as brain functional connectivity, foregoing the need to collect all phenotypes in one dataset.
Recent changes to US research funding are having far-reaching consequences that imperil the integrity of science and the provision of care to vulnerable populations. Resisting these changes, the BJPsych Portfolio reaffirms its commitment to publishing mental science and advancing psychiatric knowledge that improves the mental health of one and all.
Abstract: Anne attended Vassar College as an undergrad. In college, Anne played basketball, field hockey and lacrosse. After winter break, she no longer felt like herself, stayed in her room listening to the Rubber Soul album on repeat, and had violent thoughts. One morning, overcome by a panic, Anne ran outside screaming. Her friends raced after her and forced her to go to the little health center on campus. After a while, a psychiatrist asked Anne about the problem. She said nothing, but after a few days, it was clear she would not be let out until she talked. She told the psychiatrist she wanted to kill people. He asked Anne what she wanted to do in life, and she told him she wanted to be a doctor. He said it was a bad idea; she should take some time off from school. Eventually, her depression, which lasted for months, stopped on its own, but it was not the last time she would be depressed. Anne spent summers in Chicago working at local hospitals. Anne got good grades. She was a chemistry major and philosophy and art history minor. Anne’s pediatrician suggested she apply to institutions offering a combined MD/PhD program so she could work in the lab and/or with patients. She graduated summa cum laude in chemistry and thirteenth in the 1969 class of 400.
In this chapter of Complex Ethics Consultations: Cases that Haunt Us, the authors explore care for a patient with history of being abused, borderline personality disorder, substance use disorder, and a complex psychiatric history who was labeled by staff as a "hateful patient." He presents frequently after self-harming, requiring surgery and short-term psychiatric treatment. Complex behavioral issues and erratic acceptance of nursing and medical care led to staff frustration and unprofessional chart notes. Transfer to a long-term treatment setting was difficult to negotiate. Several months after discharge, the patient died. The authors are haunted by the patient’s desperation and deep loneliness. He wished he could remain hospitalized where he felt cared for. Authors wondered what more could have been done to help him.