Hostname: page-component-7dd5485656-s6l46 Total loading time: 0 Render date: 2025-10-31T18:40:25.554Z Has data issue: false hasContentIssue false
  • English
  • Français

Plasma Tryptophan Concentration in Depressive Illness and Mania

Published online by Cambridge University Press:  29 January 2018

M. Peet ,
J. P. Moody ,
E. P. Worrall ,
P. Walker  and
G. J. Naylor
M. Peet
Affiliation:
Royal Dundee Liff Hospital, Dundee, DD2 5NF
J. P. Moody
Affiliation:
Royal Dundee Liff Hospital, Dundee, DD2 5NF
E. P. Worrall
Affiliation:
Department of Psychiatry, The University of Dundee, Dundee, DD1 4HN
P. Walker
Affiliation:
Royal Dundee Liff Hospital, Dundee, DD2 5NF
G. J. Naylor
Affiliation:
Department of Psychiatry, The University of Dundee, Dundee, DD1 4HN
Get access Rights & Permissions [Opens in a new window]

Summary

Total and free plasma tryptophan levels were measured in depressive and manic patients before and after recovery. No change was found in total or free plasma tryptophan concentration on recovery from depressive illness. Free plasma tryptophan levels were higher in recovered manics than in active manics, and a group of four manic patients tested before and after recovery showed a significant increase in free plasma tryptophan concentration on recovery.

Information

Type
Research Article
Information
The British Journal of Psychiatry , Volume 128 , Issue 3 , March 1976 , pp. 255 - 258
Copyright
Copyright © Royal College of Psychiatrists, 1976 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Biggio, G., Fadda, F., Fanni, P., Taoliamonte, A. & Gessa, G. (1974) Rapid depletion of serum tryptophan, brain tryptohan serotonin and 5-hydroxyindoleacetic acid by tryptophan-free diet. Life Sciences, 14, 1321—9.CrossRefGoogle Scholar
Bloxam, D. L. & Warren, W. H. (1974) Error in the determination of tryptophan by the method of Denckla and Dewey. A revised procedure. Analytical Biochemistry, 60, 621—5.Google Scholar
Coppen, A. (1969) Disorders of mineral metabolism in depressive patients. Psychiatria, Neurologia, Neurochirurgia, 72, 189—93.Google Scholar
Coppen, A. (1972) Indoleamines and affective disorders. Journal of Psychiatric Research, 9, 163—71.Google Scholar
Coppen, A., Eccleston, E. G. & Peet, M. (1973) Total and free tryptophan concentration in the plasma of depressive patients. Lancet, ii, 60—3.Google Scholar
Curzon, G., Kantameneni, B. D., Winch, J., Rojas-Bueno, A., Murray-Lyon, I. M. & Williams, R. (1973) Plasma and brain tryptophan changes in experimental acute hepatic failure. Journal of Neurochemistry, 21, 137—45.Google Scholar
Denckla, W. D. & Dewey, H. K. (1967) The determination of tryptophan in plasma, liver and urine. Journal of Laboratory and Clinical Medicine, 69, 160—9.Google Scholar
Eccleston, E. G. (1973) A method for the estimation of free and total acid-soluble plasma tryptophan using an ultrafiltration technique. Clinica Chimica Acta, 48, 269—72.Google Scholar
Fernstrom, J. D. & Wurtman, R. J. (1971) Brain serotonin content: physiological dependence on plasma tryptophan levels. Science, 173, 149—52.Google Scholar
Fernstrom, J. D. & Wurtman, R. J. (1972) Brain serotonin content: physiological regulation by plasma neutral amino acids. Science, 178, 414—16.Google Scholar
Grahame-Smith, D. G. & Parfitt, A. G. (1970) Tryptophan transport across the synaptosomal membrane. Journal of Neurochemistry, 17, 1339—53.Google Scholar
Grahame-Smith, D. G. (1971) Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and L-tryptophan. Journal of Neurochemistry, 18, 1053—66.Google Scholar
Granville-Grossman, K. (1971) In Recent Advances in Clinical Psychiatry, p. 65. London: J. & A. Churchill.Google Scholar
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56—62.Google Scholar
Knott, P. J. & Curzon, G. (1972) Free tryptophan in plasma and brain tryptophan metabolism. Nature, 239 452–3.Google Scholar
Lipsett, D., Madras, B. K., Wurtman, R. J. & Munro, H. N. (1973) Serum tryptophan level after carbohydrate ingestion: selective decline in non-albumin-bound tryptophan coincident with reduction in serum free fatty acids. Life Sciences, 12, 57—64.Google Scholar
McMenamy, R. H. & Oncley, J. L. (1958) The specific binding of L-tryptophan to serum albumin. Journal of Biological Chemistry, 233, 1436—47.CrossRefGoogle ScholarPubMed
Madras, B. K., Cohen, E. L., Messing, R., Munro, H. N. & Wurtman, R. J. (1974) Relevance of free tryptophan in serum to tissue tryptophan concentrations. Metabolism, 23, 1107—16.Google Scholar
Murphy, D. L., Baker, M., Goodwin, F. K., Miller, H., Kotin, J. & Bunney, W. E. (1974) L-tryptophan in affective disorders: indoleamine changes and differential clinical effects. Psychopharmacologia, 34, 11—20.Google Scholar
Naylor, G. J., Dick, D. A. T., Dick, E. G., Le Poidevin, D. & Whyte, S. F. (1973) Erythrocyte membrane cation carrier in depressive illness. Psychological Medicine, 3, 502—8.Google Scholar
Perez-Cruet, J., Chase, T. N. & Murphy, D. L. (1974) Dietary regulation of brain tryptophan metabolism by plasma ratio of free tryptophan and neutral amino acids in humans. Nature, 248, 693—5.Google Scholar
Prange, A. J., Wilson, I. C., Lynn, C. W., Alltop, L. B. & Strikeleather, R. A. (1974) L-tryptophan in mania. Archives of General Psychiatry, 30, 56—62.Google Scholar
Rees, J. R., Allsopp, M. N. E. & Hulin, R. P. (1974) Plasma concentrations of tryptophan and other amino acids in manic-depressive patients. Psychological Medicine, 4, 354—77.Google Scholar
Tagliamonte, A., Biggio, G., Vargiu, L. & Gessa, G. L. (1973) Free tryptophan in serum controls brain tryptophan level and serotonin synthesis. Life Sciences, 12, 277—87.Google Scholar
Young, V. R., Hussein, M. A., Murray, E. & Scrimshaw, N. S. (1969) Tryptophan intake, spacing of meals, and diurnal fluctuations of plasma tryptophan in men. American Journal of Clinical Nutrition, 22, 1563—7.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.