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Pathology, Phenomenology and the Dopamine Hypothesis of Schizophrenia

Published online by Cambridge University Press:  02 January 2018

P. J. McKenna
P. J. McKenna*
Affiliation:
Academic Department of Psychiatry, University of Leeds, Leeds LS2 9LT
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Extract

The dopamine hypothesis of schizophrenia implies that positive schizophrenic symptoms should be understandable by reference to brain structures receiving a dopamine innervation, or in terms of the functional role of dopamine itself. The basal ganglia, ventral striatum, septo-hippocampal system, and prefrontal cortex, sites of mesotelencephalic dopamine innervation, are examined and it is argued that their dysfunction could form the basis of particular schizophrenic symptom classes. The postulated involvement of dopamine in reinforcement processes might further assist such interpretations. This type of analysis can be extended to other categories of schizophrenic psychopathology.

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Review Article
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The British Journal of Psychiatry , Volume 151 , Issue 3 , September 1987 , pp. 288 - 301
Copyright
Copyright © Royal College of Psychiatrists, 1987 

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