Hostname: page-component-7dd5485656-wlg5v Total loading time: 0 Render date: 2025-10-31T19:56:54.272Z Has data issue: false hasContentIssue false
  • English
  • Français

Negative Symptoms at Discharge and Outcome in Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Hai-Gwo Hwu ,
Happy Tan ,
Chu-Chang Chen  and
Ling-Ling Yeh
Hai-Gwo Hwu*
Affiliation:
Department of Psychiatry, College of Medicine, National Taiwan University
Happy Tan
Affiliation:
Department of Psychiatry, College of Medicine, National Taiwan University
Chu-Chang Chen
Affiliation:
Department of Psychiatry, College of Medicine, National Taiwan University
Ling-Ling Yeh
Affiliation:
Department of Psychiatry, College of Medicine, National Taiwan University
*
Professor Hai-Gwo Hwu, Department of Psychiatry, National Taiwan University Hospital, No. 7 Chung-Shan S. RD, Taipei, Taiwan 100, Republic of China
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

The clinical significance in schizophrenia of positive and negative symptoms at discharge was assessed.

Method

Of schizophrenic patients fulfilling DSM–III criteria, 113 were recruited for this study. Personal, social and psychopathological data were collected and all cases were followed up at one and two years after discharge.

Results

The presence of positive symptoms (64 cases), without concomitant negative symptoms, did not predict the follow-up social function and positive symptom score. Conversely, the presence of negative symptoms (31 cases) predicted worse social functioning (P < 0.05 to P < 0.005) and higher positive symptom scores (P < 0.01) at follow-up using MANOVA. Eighteen cases (15.9%) had neither positive nor negative symptoms and had the best clinical outcome.

Conclusions

Negative, but not positive, symptoms assessed at discharge are an important predictor of poor outcome. In addition, negative symptoms may themselves expose a biological vulnerability to the presence of positive symptoms.

Information

Type
Papers
Information
The British Journal of Psychiatry , Volume 166 , Issue 1 , January 1995 , pp. 61 - 67
Copyright
Copyright © 1995 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Andreasen, N. C. & Olsen, S. (1982) Negative v. positive schizophrenia. Archives of General Psychiatry, 39, 789–794.Google Scholar
Bartko, J. J. & Carpenter, W. T. (1976) On the methods and theory of reliability. Journal of Nervous and Mental Disease, 163, 307–317.Google Scholar
Biehl, H., Maurer, K., Jung, E., et al (1989) The WHO psychological impairment rating schedule II: impairments in schizophrenics, cross-sectional and longitudinal perspective – the Mannheim experience in two independent samples. British Journal of Psychiatry, 155 (suppl. 7): 71–77.Google Scholar
Bleuler, E. (1950) Dementia Praecox or the Group of Schizophrenia. Translated by Zinkin, J. New York: International University Press.Google Scholar
Cannon, T. D. & Mednick, S. A. (1993) The schizophrenic high-risk project in Copenhagen: three decades of progress. Acta Psychiatrica Scandinavica, 370 (suppl.): 33–47.Google Scholar
Carpenter, W. T. & Buchanan, R. W. (1989) Domains of psychopathology relevant to the study of etiology and treatment of schizophrenia. In Schizophrenia: Scientific Progress (eds Schulz, S. C. & Tamminga, C. T.), pp. 13–22. Oxford: Oxford University Press.Google Scholar
Crow, T. J. (1980) Molecular pathology of schizophrenia: more than one disease process? British Medical Journal, 280, 66–68.Google Scholar
Davila, R., Zumarraga, M., Andia, I., et al (1989) Dopaminergic balance and subtypes of schizophrenia. British Journal of Psychiatry, 154 (suppl. 4), 57–60.Google Scholar
Hwu, H. G., Sun, M. C., Chuu, T. H., et al (1987) Community psychiatric rating scale: reliability and clinical applicability. Chinese Psychiatry, 1, 111–122.Google Scholar
Kay, S. R. (1990) Significance of the positive-negative distinction in schizophrenia. Schizophrenia Bulletin, 16, 635–652.Google Scholar
Kay, S. R., Fiszbein, A., Lindenmayer, J.-P., et al (1986) Positive and negative syndromes in schizophrenia as a function of chronicity. Acta Psychiatrica Scandinavica, 74, 507–518.Google Scholar
Kay, S. R., & Opler, L. A. (1987) The positive-negative dimension in schizophrenia: its validity and significance. Psychiatric Development, 2, 79–103.Google Scholar
Kay, S. R., & Singh, M. M. (1979) Cognitive abnormality in schizophrenia: a dual-process model. Biological Psychiatry, 14, 155–176.Google Scholar
Kay, S. R., & Singh, M. M. (1989) The positive-negative distinction in drug-free schizophrenic patients: stability, response to neuroleptic and prognostic significance. Archives of General Psychiatry, 46, 711–718.Google Scholar
Kraepelin, E. (1919) Dementia Praecox and Paraphrenia (transl. by Barclay, R. M.). New York: Robert E. Krieger.Google Scholar
Kulhara, P. & Chandiramani, K. (1990) Positive and negative subtypes of schizophrenia. A follow-up study from India. Schizophrenia Research, 3, 107–116.Google Scholar
Lenzenweger, M. F., Dworkin, R. H. & Wethington, E. (1989) Models of positive and negative symptoms in schizophrenia: an empirical evaluation of latent structure. Journal of Abnormal Psychology, 98, 62–70.Google Scholar
McCreadie, R. G., Watt, J. A. G., Greene, J. G., et al (1989) The Scottish first episode schizophrenia study VII: two-year follow-up. Acta Psychiatrica Scandinavica, 80, 597–602.Google Scholar
McGlashan, T. H. & Fenton, W. S. (1992) The positive-negative distinction in schizophrenia: review of natural history validators. Archives of General Psychiatry, 49, 63–72.Google Scholar
Pilowsky, L. S., Kerwin, R. W. & Murray, R. H. (1993) Schizophrenia: a neurodevelopmental perspectives. Neuropsychopharmacology, 9, 83–91.Google Scholar
SPSS (1988) spss/pc+ Advanced Statistics, v2.0, 153–182. Chicago: SPSS Inc.Google Scholar
Strauss, J. S., Carpenter, W. T. & Bartko, J. J. (1974) The diagnosis and understanding of schizophrenia. Part 3: Speculation on the processes that underlie schizophrenic symptoms and signs. Schizophrenia Bulletin, 11, 61–75.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.