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Ethical Issues in Genetic Linkage Studies of Psychiatric Disorders

Published online by Cambridge University Press:  02 January 2018

Joyce Rachel Alexander ,
Bernard Lerer  and
Miron Baron
Joyce Rachel Alexander*
Affiliation:
Department of Psychiatry, Hadassah University Hospital, Post Office Box 12000, Jerusalem 91120, Israel
Bernard Lerer
Affiliation:
Department of Psychiatry, Hadassah University Hospital, and Department of Psychiatry, Hebrew University – Hadassah Medical School, Jerusalem, Israel
Miron Baron
Affiliation:
Division of Psychogenetics, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, 722 West 168th Street, New York, New York 10032, USA
*
∗ Correspondence
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Extract

Recent advances in molecular genetics have radically altered the prospects for determining the role of heredity in the transmission of major psychiatric disorders. Identification of the actual gene(s) involved, elucidation of their structure, and determination of their products are the steps which theoretically follow successful demonstration of linkage (Gurling, 1985; Baron & Rainer, 1988). Consideration of the ethical issues raised by genetic linkage studies is therefore now of paramount importance. This article focuses on the problems raised by the research process, and not on the ethical implications of the results eventually obtained.

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The British Journal of Psychiatry , Volume 160 , Issue 1 , January 1992 , pp. 98 - 102
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Andreasen, N. C., Endicott, J., Spitzer, R. L., et al (1977) The family history method using diagnostic criteria. Archives of General Psychiatry, 34, 1229–1235.CrossRefGoogle ScholarPubMed
Baron, M. & Rainer, J. D. (1988) Molecular genetics and human disease. Implications for modern psychiatric research and practice. British Journal of Psychiatry, 152, 741–753.CrossRefGoogle ScholarPubMed
Benson, P. R., Roth, L. H. & Winslade, W. J. (1985) Informed consent in psychiatric research: preliminary findings from an ongoing investigation. Social Science and Medicine, 20, 1331–1341.Google Scholar
Cassel, C. K. (1987) Informed consent for research in geriatrics: history and concepts. Journal of the American Geriatrics Society, 35, 542–544.CrossRefGoogle ScholarPubMed
Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview: the schedule for affective disorders and schizophrenia. Archives of General Psychiatry, 35, 857–862.Google Scholar
Gurling, H. M. G. (1985) Application of molecular biology to mental illness – analysis of genomic DNA and brain MRNA. Psychiatric Development, 3, 257–273.Google ScholarPubMed
Merikangas, K. R., Spence, A. & Kupfer, D. (1989) Linkage studies of bipolar disorder: methodological and analytic issues. Archives of General Psychiatry, 46, 1137–1141.CrossRefGoogle ScholarPubMed
Presidents Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioural Research (1983) Screening and Counseling for Genetic Conditions: A Report on the Ethical, Social, and Legal Implications of Genetic Screening, Counseling and Education Programs. Washington, DC: US Government Printing Office.Google Scholar
Stanley, B., Stanley, M., Lautin, A., et al (1981) Preliminary findings on psychiatric patients as research participants: a population at risk? American Journal of Psychiatry, 138, 669–671.Google ScholarPubMed
Turnbull, J. E., McLeod, J. D., Callahan, J. M., et al (1988) Who should ask? Ethical interviewing in psychiatric epidemiology studies. American Journal of Orthopsychiatry, 58, 228–239.Google Scholar
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