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A Diagnostic Pointer to Adult Metachromatic Leucodystrophy

Published online by Cambridge University Press:  29 January 2018

John A. O. Besson
John A. O. Besson*
Affiliation:
Bangour Village Hospital, West Lothian, Scotland
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Extract

Adult metachromatic leucodystrophy (MLD) is a rare demyelinating disease of the central nervous system caused by a genetic autosomal recessive defect and mediated through a deficiency in the enzyme arylsulphatase A (Peiffer, 1970). The initial manifestation may take the form of symptoms suggestive of schizophrenia or dementia (Sourander et al, 1962; Austin et al, 1968).

Information

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 2 , August 1980 , pp. 186 - 187
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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References

Austin, J., Armstrong, D., Fouch, S., Mitchell, C., Stumpf, D., Shearer, L. & Briner, O. (1968) Metachromatic leucodystrophy (MLD)—viii MLD in adults; Diagnosis and pathogenesis. Archives of Neurology, 18, 225–40.CrossRefGoogle Scholar
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Sourander, P. & Svennerholm, L. (1962) Sulphatide lipidosis in the adult with the clinical picture of progressive organic dementia with epileptic seizures. Acta Neuropathologica, 1, 384–96.CrossRefGoogle Scholar
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