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A Controlled Assessment of Propranolol in the Treatment of Neuroleptic-Induced Akathisia

Published online by Cambridge University Press:  29 January 2018

Lenard Adler ,
Burt Angrist ,
Eric Peselow ,
June Corwin ,
Robert Maslansky  and
John Rotrosen
Lenard Adler*
Affiliation:
Department of Psychiatry, New York University Medical Center and Psychiatry Service (116A), New York Veteran's Administration Medical Center First Avenue and East 24th Street, New York, NY10010, USA
Burt Angrist
Affiliation:
Department of Psychiatry, New York University Medical Center and Psychiatry Service (116A), New York Veteran's Administration Medical Center First Avenue and East 24th Street, New York, NY10010, USA
Eric Peselow
Affiliation:
Department of Psychiatry, New York University Medical Center and Psychiatry Service (116A), New York Veteran's Administration Medical Center First Avenue and East 24th Street, New York, NY10010, USA
June Corwin
Affiliation:
Department of Psychiatry, New York University Medical Center and Psychiatry Service (116A), New York Veteran's Administration Medical Center First Avenue and East 24th Street, New York, NY10010, USA
Robert Maslansky
Affiliation:
Department of Medicine, New York University Medical Center, 550 First Avenue, New York, NY10016, USA
John Rotrosen
Affiliation:
Department of Psychiatry, New York University Medical Center and Psychiatry Service (116A), New York Veteran's Administration Medical Center First Avenue and East 24th Street, New York, NY10010, USA
*
∗ Correspondence.
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Abstract

Twelve patients with neuroleptic-induced akathisia were treated in a randomised, double-blind, cross-over design with propranolol and matching placebo. Propranolol caused significant decrements in both subjective and objective ratings of akathisia, but not in anxiety scores. This confirms prior findings of the efficacy of propranolol in akathisia induced by neuroleptic treatment.

Information

Type
Papers
Information
The British Journal of Psychiatry , Volume 149 , Issue 1 , July 1986 , pp. 42 - 45
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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References

Adler, L., Angrist, B., Peselow, E. et al. (1985) Efficacy of propranolol in neuroleptic-induced akathisia. Journal of Clinical Psychophar-macology, 5, 164–166.Google Scholar
Ayd, F. J. (1961) A survey of drug-induced extrapyramidal reactions. Journal of the American Medical Association, 175, 1054–1060.Google Scholar
Braude, W. M., Barnes, T. R. E. & Gore, S. M. (1983) Clinical characteristics of akathisia: A systematic investigation of acute psychiatric inpatient admissions. British Journal of Psychiatry, 143, 139–150.CrossRefGoogle ScholarPubMed
DiMascio, A., Bernardo, D. L., Greenblatt, D. & Marder, J. E. (1976) A controlled trial of amantadine in drug-induced extrapyramidal disorders. Archives of General Psychiatry, 33, 559–602.Google Scholar
Donlon, P. (1973) The therapeutic use of diazepam for akathisia. Psychosomatics, 14, 222–225.Google Scholar
Freyhan, F. A. (1958) Trifluperazine: Clinical and Pharmacological Aspects. Philadelphia: Lea & Febiger.Google Scholar
Gacrar, D., Hamilton, J. & Belmatter, R. (1978) Intravenous diazepam in the treatment of neuroleptic-induced dystonia or akathisia. American Journal of Psychiatry, 135, 1232–1233.Google Scholar
Gerbino, L. (1985) Personal Communication.Google Scholar
Lipinski, J. F., Zubenko, G. S., Cohen, B. M. & Barriera, P. J. (1983) Propranolol in the treatment of neuroleptic induced akathisia. Lancet, i, 685–686.CrossRefGoogle Scholar
Lipinski, J. F., Zubenko, G. S., Cohen, B. M. & Barriera, P. J. (1984) Propranolol in the treatment of neuroleptic induced akathisia. American Journal of Psychiatry, 141, 412–415.Google Scholar
Marsden, C. D. & Jenner, P. (1980) The pathophysiology of extrapyramidal side-effects of neuroleptic drugs. Psychological Medicine, 10, 55–72.Google Scholar
Raskin, D. E. (1972) Akathisia: A side-effect to be remembered. American Journal of Psychiatry, 129, 345–7.CrossRefGoogle ScholarPubMed
Ratey, J. J., Sorgl, P. & Polakoff, S. (1985) Nadolol as a treatment for akathisia. American Journal of Psychiatry, 142, 640–642.Google ScholarPubMed
Simpson, G. M. & Angus, J. W. S. (1970) A rating scale for extrapyramidal side-effects. Acta Psychiatrica Scandinavica, 212 (Suppl), 11–19.CrossRefGoogle ScholarPubMed
Van Putten, T. (1974) Why do schizophrenic patients refuse to take their drugs? Archives of General Psychiatry, 31, 67–72.Google Scholar
Van Putten, T. (1975) The many faces of akathisia. Comprehensive Psychiatry, 16, 43–47.Google Scholar
Zubenko, G. S., Lipinski, J. F., Cohen, B. M. & Barrera, P. J. (1984) Comparison of metoprolol and propranolol in the treatment of akathisia. Psychiatry Research, 11, 143–148.Google Scholar
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