Hostname: page-component-7f64f4797f-fz5kh Total loading time: 0 Render date: 2025-11-04T00:41:35.464Z Has data issue: false hasContentIssue false
  • English
  • Français

Evaluation of a New Tranquillizer—Benzquinamide (P2647) by a Sequential Method

Published online by Cambridge University Press:  29 January 2018

K. Davison
K. Davison*
Affiliation:
The National Hospital for Nervous Diseases, Queen Square, London, W.C.1
Get access Rights & Permissions [Opens in a new window]

Extract

Benzquinamide (P2647 Pfizer) is a new benzoquinolizine derivative with the structural formula

Animal studies have shown that it is a potent suppressor of conditioned avoidance behaviour, but it does not influence the release of central amines, has little sedative action and is free from serious toxic effect (personal communication, Pfizer Ltd.). An uncontrolled pilot study found it to be effective in relieving anxiety in neurotic patients (Smith, 1962). In the present trial the effect of benzquinamide (P2647) on anxiety symptoms is compared with a placebo and amylobarbitone in the same dosage using the method of sequential analysis.

Information

Type
Research Article
Information
The British Journal of Psychiatry , Volume 109 , Issue 461 , July 1963 , pp. 539 - 543
Copyright
Copyright © Royal College of Psychiatrists, 1963

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Armitage, P. (1960). Sequential Medical Trials. Oxford: Blackwell Scientific Publications.Google Scholar
Hamilton, M. (1959). “The assessment of anxiety states by rating”, Brit. J. med. Psychol., 32, 50–55.CrossRefGoogle Scholar
Sainsbury, P., and Lucas, C. J. (1959). “Sequential methods applied to the study of prochlorperazine”, Brit. med. J., ii, 737–740.CrossRefGoogle Scholar
Smith, M. E. (1962). “A pilot study of P2647, a new benzoquinolizine derivative employed as a psychotherapeutic agent in 44 cases of overt anxiety”, Amer. J. Psychiat., 118, 937–938.CrossRefGoogle Scholar
Weatherall, M. (1962). “Tranquillisers”, Brit. med. J., i, 1219–1224.CrossRefGoogle Scholar
Wolf, S., and Pinsky, R. H. (1954). “Effects of placebo administration and occurrence of toxic reactions”, J. Amer. med. Ass., 155, 339–341.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.