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Dopamine Receptors and Antipsychotic Drug Response

Published online by Cambridge University Press:  06 August 2018

Roger K. Sunahara ,
Philip Seeman ,
Hubert H. M. Van Tol  and
Hyman B. Niznik
Roger K. Sunahara*
Affiliation:
Departments of Psychiatry and Pharmacology, University of Toronto, and Laboratory of Molecular Neurobiology, Clarke Institute of Psychiatry, Toronto
Philip Seeman
Affiliation:
Departments of Psychiatry and Pharmacology, University of Toronto, and Laboratory of Molecular Neurobiology, Clarke Institute of Psychiatry, Toronto
Hubert H. M. Van Tol
Affiliation:
Departments of Psychiatry and Pharmacology, University of Toronto, and Laboratory of Molecular Neurobiology, Clarke Institute of Psychiatry, Toronto
Hyman B. Niznik
Affiliation:
Departments of Psychiatry and Pharmacology, University of Toronto, and Laboratory of Molecular Neurobiology, Clarke Institute of Psychiatry, Toronto
*
∗ Department of Pharmacology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
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Abstract

Dopamine receptors have been divided into two major types – D1 and D2 – based primarily on pharmacological and biochemical criteria. Recent advances in the molecular biology of the dopamine receptor system have allowed the identification and characterisation of at least five distinct neuronal dopamine receptor genes (D1 to D5). These genes encode dopamine receptors belonging to the D1 receptor family, termed D1 and D5, and three D2-like receptors, termed D2, D3 and D4. These receptors are distinguished on the basis of their primary structure, chromosomal location, mRNA size and tissue distribution, and biochemical and pharmacological differences. Although individually these receptor subtypes may not be directly and exclusively involved in the maintenance or expression of schizophrenia, alterations of any of the receptors may contribute to the perturbation or instability of dopaminergic homeostasis in the brain. What was once thought to be a simple two-receptor system seems to have emerged as an intricate and interactive entity. This review summarises what is currently understood about dopamine receptors, their role in antipsychotic drug action, and their association with psychosis.

Information

Type
Research Article
Information
The British Journal of Psychiatry , Volume 163 , Issue S22: The Psychopharmacology of Schizophrenia , December 1993 , pp. 31 - 38
Copyright
Copyright © 1993 The Royal College of Psychiatrists 

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