Hostname: page-component-cb9f654ff-9b74x Total loading time: 0 Render date: 2025-09-01T10:34:59.962Z Has data issue: false hasContentIssue false
  • English
  • Français

Fabrication of an Electrochemical Sensor for Glucose Detection usingZnO Nanorods

Published online by Cambridge University Press:  24 February 2016

Sanghamitra Mandal ,
Mohammed Marie  and
Omar Manasreh
Sanghamitra Mandal*
Affiliation:
Department of Electrical Engineering, University of Arkansas, Fayetteville, AR 72701, U.S.A.
Mohammed Marie
Affiliation:
Microelectronics Photonics Program, University of Arkansas, Fayetteville, AR 72701, U.S.A.
Omar Manasreh
Affiliation:
Department of Electrical Engineering, University of Arkansas, Fayetteville, AR 72701, U.S.A.
*
*(Email: sm009@uark.edu)
Get access

Abstract

An electrochemical glucose sensor based on zinc oxide (ZnO) nanorods isfabricated, characterized and tested. The ZnO nanorods are synthesized on indiumtitanium oxide (ITO) coated glass substrate, using the hydrothermal sol-geltechnique. The working principle of the sensor under investigation is based onthe electrochemical reaction taking place between cathode and anode, in thepresence of an electrolyte. A platinum plate, used as the cathode andNafion/Glucose Oxidase/ZnO nanorods/ITO-coated glass substrate used as anode, isimmersed in pH 7.0 phosphate buffer solution electrolyte to test for thepresence of glucose. Several amperometric tests are performed on the fabricatedsensor to determine the response time, sensitivity and limit of detection of thesensor. A fast response time less than 3 s with a high sensitivity of 1.151 mAcm-2mM-1 and low limit of detection of 0.089 mM isreported. The glucose sensor is characterized using the cyclic voltammetrymethod in the range from -0.8 – 0.8 V with a voltage scan rate of 100mV/s.

Keywords

x-ray diffraction (XRD)sol-gelnanostructure

Information

Type
Articles
Information
MRS Advances , Volume 1 , Issue 13: Nanomaterials and Synthesis , 2016 , pp. 861 - 867
Copyright
Copyright © Materials Research Society 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

REFERENCES

World Health Organization, www.who.int/diabetes/wdd_2015/en/ (last seen on 11/16/2015).Google Scholar
Zhou, J., Xu, N. S. and Wang, Z. L, Dissolving Behavior and Stability of ZnO Wires in Biofluids: A Study on Biodegradability and Biocompatibility of ZnO Nanostructures, Adv. Mater. 18 (2006) 2432–2435.Google Scholar
Zhao, Z., Lei, W., Zhang, X., Wang, B., & Jiang, H. ZnO-Based Amperometric Enzyme Biosensors. Sensors (Basel, Switzerland), 10(2), (2010) 1216–1231.CrossRefGoogle ScholarPubMed
Jin Tan, Mein, Zhong, Shu, Li, Jun, Chen, Zhikuan, and Chen, Wei, Air-Stable Efficient Inverted Polymer Solar Cells Using Solution-Processed Nanocrystalline ZnO Interfacial Layer, ACS Applied Materials & Interfaces, 5 (11), (2013) 4696–4701.CrossRefGoogle Scholar
Zuow, Juan and Erbe, Andreas, Optical and electronic properties of native zinc oxide films on polycrystalline Zn, Phys. Chem. Chem. Phys. 12 (2010), 11467–11476.CrossRefGoogle Scholar
Ibupoto, Z.H.; Khun, K.; Eriksson, M.; AlSalhi, M.; Atif, M.; Ansari, A.; Willander, M. Hydrothermal Growth of Vertically Aligned ZnO Nanorods Using a Biocomposite Seed layer of ZnO Nanoparticles. Materials, 6, (2013) 3584–3597.Google Scholar
Putzbach, W. and Ronkainen, N. J., Immobilization Techniques in the Fabrication of Nanomaterial-Based Electrochemical Biosensors: A Review, Sensors 13, (2013) 4811–4840.CrossRefGoogle ScholarPubMed
Wilke, D., Müller, H. and Kolytsheva, N., Activated platinum electrodes as transducer for a glucose sensor using glucose oxidase in a photopolymer membrane, Fresenius J Anal Chem, 357, (1997) 534–538.Google Scholar
Kong, Tao, Chen, Yang, Ye, Yiping, Zhang, Kun, Wang, Zhenxing, and Wang, Xiaoping, An amperometric glucose biosensor based on the immobilization of glucose oxidase on the ZnO nanotubes, Sensors and Actuators B, 138, (2009) 344–350.CrossRefGoogle Scholar
Ahmad, R., Tripathy, N., Kim, J. H. and Hahn, Y., Highly selective wide linear-range detecting glucose biosensors based on aspect-ratio controlled ZnO nanorods directly grown on electrodes, Sensors & Actuators B. Chemical, 174, (2012) 195–201.Google Scholar
Wang, J. X., Sun, X.W., Wei, A., Lei, Y., Cai, X. P., Li, C. M. and Dong, Z. L., Zinc oxide nanocomb biosensor for glucose detection, Applied Physics Letters, 88, (2006) 233106.Google Scholar
Wei, A., Sun, X. W., Wang, J. X., Lei, Y., Cai, X. P., Li, C. M., Dong, Z. L. and Huang, W., Enzymatic glucose biosensor based on ZnO nanorod array grown by hydrothermal decomposition, Applied Physics Letters, 89, (2006) 123902.Google Scholar
Yang, Kun, She, Guang-Wei, Wang, Hui, Ou, Xue-Mei, Zhang, Xiao-Hong, Lee, Chun-Sing and Lee, Shuit-Tong, ZnO Nanotube Arrays as Biosensors for Glucose, The Journal of Physical Chemistry C, 113, (2009) 20169–20172.Google Scholar
You, Xueqiu, Pikul, James H., King, William P. and Pak, James J.., Zinc oxide inverse opal enzymatic biosensor, Appl. Phys. Lett., 102, (2013) 253103.CrossRefGoogle Scholar
Yu, Jiuhong, Liu, Songqin and Ju, Huangxian, Glucose sensor for flow injection analysis of serum glucose based on immobilization of glucose oxidase in titania sol–gel membrane, Biosensors and Bioelectronics, 19, (2003) 401–409.CrossRefGoogle ScholarPubMed
Liu, J., Guo, C., Li, C. M., Li, Y., Chi, Q., Huang, X., Liao, L., and Yu, T., Carbon-decorated ZnO nanowire array: A novel platform for direct electrochemistry of enzymes and biosensing applications, Electrochemistry Communications, 11, (2009) 202–205.CrossRefGoogle Scholar
Ansari, A. A., Solanki, P. R. and Malhotra, B. D., Sol-gel derived nanostructured cerium oxide film for glucose sensor, Applied Physics Letters, 92, (2008) 263901.Google Scholar
Guo, L., Yang, S., Yang, C., Yu, P., Wang, J., Ge, W. and Wong, G. K. L., Highly monodisperse polymer-capped ZnO nanoparticles, Preparation and optical properties, Appl. Phys. Lett., 76, (2000) 2901–2903.CrossRefGoogle Scholar
Gu, Y. and Kuskovsky, Igor L. and Yin, M. and O’Brien, S. and Neumark, G. F., Quantum confinement in ZnO nanorods, Applied Physics Letters, 85, (2004) 3833–3835.Google Scholar
Cheng, An-Jen, Tzeng, Yonhua, Xu, Hui, Alur, Siddharth, Wang, Yaqi, Park, Minseo, Wu, Tsung-hsueh, Shannon, Curtis, Kim, Dong-Joo and Wang, Dake, Raman analysis of longitudinal optical phonon-plasmon coupled modes of aligned ZnO nanorods, Journal of applied physics 105 (2009) 073104.Google Scholar
Hsu, Julia W. P., Tian, Zhengrong R.,Simmons, Neil C.,Matzke, Carolyn M.,Voigt, James A., and, Liu, Jun, Directed Spatial Organization of Zinc Oxide Nanorods, Nano Letters, 5 (1), (2005) 83–86.Google Scholar
Monshi, A., Foroughi, M. F., and Monshi, M. R., Modified Scherrer Equation to Estimate More Accurately Nano-Crystallite Size Using XRD, World Journal of Nanoscience and Engineering 2 (2012) 154–160.Google Scholar
Armbruster, David A, and Pry, Terry, Limit of Blank, Limit of Detection and Limit of Quantitation, The Clinical Biochemist Reviews 29.Suppl 1, (2008) S49–S52.Google Scholar
Shrivastava, A and Gupta, VB, Methods for the determination of limit of detection and limit of quantitation of the analytical methods, Chron Young Sci. 2 (2011) 21–25.Google Scholar