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Parathyroid carcinoma: a tertiary centre’s experience over 15 years

Published online by Cambridge University Press:  23 October 2024

Jeremy Wong Open the ORCID record for Jeremy Wong [Opens in a new window] ,
Alfred Addison  and
Ramez Nassif
Jeremy Wong*
Affiliation:
Department of Ears, Nose and Throat, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK
Alfred Addison
Affiliation:
Department of Ears, Nose and Throat, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK
Ramez Nassif
Affiliation:
Department of Ears, Nose and Throat, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK
*
Corresponding author: Jeremy Wong; Email: Jeremy.wong3@nhs.net
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Abstract

Objectives

The aim of this research is to determine the rate of recurrence, metastasis and survival outcomes of patients diagnosed with and treated for parathyroid carcinoma.

Methods

This research is a retrospective chart review for patients diagnosed with parathyroid carcinomas between 1 January 2007 and 31 December 2022 in a UK tertiary centre.

Results

Fourteen patients were identified, all of whom received surgery following their diagnosis. On presentation, all patients (100 per cent) were hypercalcaemic, with two patients (14 per cent) having metastatic lesions. There was a single case (7 per cent) of loco-regional recurrence following surgery. Six patients passed away after a median follow up of 2.5 years, four due to causes related to parathyroid carcinoma.

Conclusion

Surgical excision remains the mainstay of treatment, but this can only be undertaken after the patient has been medically stabilised. Mortality in this group of patients generally arose from the effects of hypercalcaemia. Metastasis and recurrence from our cohort were rare, but long-term follow up with monitoring of calcium and parathyroid hormone levels remain keys.

Keywords

Parathyroid neoplasmsParathyroidectomySurvival rateHypercalcemiaHyperparathyroidismPrimary

Information

Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 139 , Issue 7 , July 2025 , pp. 603 - 609
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED.

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Footnotes

Jeremy Wong takes responsibility for the integrity of the content of the paper.

Presented at 7th World Congress of the International Federation of Head and Neck Oncologic Societies, Rome, Italy 21–25 June 2023.

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