Hostname: page-component-7dd5485656-k8lnt Total loading time: 0 Render date: 2025-10-24T22:06:42.261Z Has data issue: false hasContentIssue false
  • English
  • Français

Epilepsy, Aging and Global Disparities: A Role for Mitochondrial Therapies?

Published online by Cambridge University Press:  28 April 2025

Amza Ali Open the ORCID record for Amza Ali [Opens in a new window] ,
Peter Carlen Open the ORCID record for Peter Carlen [Opens in a new window]  and
Ana Andreazza
Amza Ali*
Affiliation:
Department of Medicine, Faculty of Medical Sciences, University of the West Indies, Mona, Jamaica
Peter Carlen
Affiliation:
Krembil Research Institute, Toronto, Ontario, Canada
Ana Andreazza
Affiliation:
Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada
*
Corresponding author: Amza Ali; Email: amzaalimd@gmail.com
Get access Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. Please use the Get access link above for information on how to access this content.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Keywords

agingantioxidantsdisparitiesepilepsymitochondria

Information

Type
Commentary
Information
Canadian Journal of Neurological Sciences , First View , pp. 1 - 3
Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Patel, M. Mitochondrial dysfunction and oxidative stress: cause and consequence of epileptic seizures. Free Radic Biol Med. 2004;37(12):1951–1962.10.1016/j.freeradbiomed.2004.08.021CrossRefGoogle ScholarPubMed
Wallace, DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet. 2005;39:359–407.10.1146/annurev.genet.39.110304.095751CrossRefGoogle ScholarPubMed
Andreazza, AC, Kauer-Sant’Anna, M, Frey, BN, et al. Oxidative stress markers in bipolar disorder: a meta-analysis. J Affect Disorders. 2008;111(2-3):135–144.10.1016/j.jad.2008.04.013CrossRefGoogle ScholarPubMed
Patel, M. A metabolic paradigm for epilepsy. Epilepsy Curr. 2018;18(5):318–322.10.5698/1535-7597.18.5.318CrossRefGoogle ScholarPubMed
Ji, D, Mylvaganam, S, Ravi Chander, P, Tarnopolsky, M, Murphy, K, Carlen, P. Mitochondria and oxidative stress in epilepsy: advances in antioxidant therapy. Front Pharmacol. 2025;15:1505867. https://doi.org/10.3389/fphar.2024.1505867.CrossRefGoogle ScholarPubMed
Zachos, KA, Gamboa, JA, Dewji, AS, Lee, J, Brijbassi, S, Andreazza, AC. The interplay between mitochondria, the gut microbiome and metabolites and their therapeutic potential in primary mitochondrial disease. Front Pharmacol. 2024;15:1428242.10.3389/fphar.2024.1428242CrossRefGoogle ScholarPubMed
Abdelmalik, PA, Politzer, N, Carlen, PL. Magnesium as an effective adjunct therapy for drug resistant seizures. Can J Neurol Sci. 2012;39(3):323–327.10.1017/S0317167100013457CrossRefGoogle Scholar