This chapter examines the earliest cases of sorcery trials in Mexico in 1520s and 1530s. A discussion is presented of the ways that Spanish women learned magic from Nahua women in Mexico City. Spanish women adopted multiple Nahua cultural behaviors. These included understanding the role of the tiçitl; metaphysics of Nahua forms of healing; the god Tezcatlipoca; and invocations in Nahuatl language. Spanish women learned about the Nahua cultural significance of sweeping and brooms, associated with cosmic order and cleanliness. Spanish women also quickly learned Nahuatl, communicating with domestic servants and in the street, where the Nahuatl word for market, tianguis, became the first Nahuatl loanword in Mexican Spanish, as early as 1524. Other cases against Spanish women show that these women quickly adopted Mesoamerican plant material for spells and that these women understood the rite of corn hurling (tlapohualiztli).