In 1537 in Mexico City, Zumárraga’s Inquisition pursued a massive investigation into a network of suspected African and Spanish witches. Those punished were two African slaves, probably of Senegambia, Marta and María. Two freed slaves, María de Espinosa and Margarita Pérez, a Spanish woman Isabel de Morales, and a Nahua man whose name was Antón Cuatecu or Coatecu, were also condemned. The African women were accused of performing sorcery for multiple Spanish women, who were never arrested or prosecuted. These women offered multiple forms of love magic for their Spanish women patrons. Cuatecu was the cultural intermediary and supplied both the African and Spanish women with Mesoamerican plant material, which is not identified by name, only as roots, powders, which is clear evidence that Spanish and African women communicated with Cuatecu in Nahuatl. This network was multiethnic and composed of Senegambian, Maghrebi, Spanish, and Nahua peoples.