The chapter outlines the long history of the maker’s knowledge tradition from Hippocrates to Vico. It explores five specific paradigmatic moments during which the fundamental intertwinement between making and knowing was problematised. First, it addresses the Hippocratic cogitations on the nature of knowledge as a practical and theoretical activity. Second, it engages with Plato and Aristotle’s desperate attempts to purify episteme from any practical concerns. Third, it follows the transformation of the concept of episteme in the post-Aristotelian debates on the so-called stochastic arts. Fourth, it explores how the very concept of ‘knowledge by making and doing’ is gradually concocted in the Middle Ages and Renaissance. Finally, it shows how the idea of knowing by making is gradually integrated into the epistemology of modern science and history since Giordano Bruno.