The chapter explores the changing role of science and technology in global development, highlighting their potential for fostering sustainability. While historically, technology played a minor role, the 2000s saw the internet and digital technologies addressing challenges in health, education, and agriculture. The focus shifted to "green growth," emphasizing renewable energy, smart agriculture, and eco-friendly solutions. Key areas include renewable energy, waste and water management, agriculture, healthcare, mobile, education, and disaster tech. These innovations tackle issues in developing countries such as poverty, health, and environmental conservation. However, infrastructure limitations, skill gaps, high costs, corruption, and legal issues hinder progress. Adoption is challenging, requiring adaptation to local contexts. Sustainability concerns highlight the need for affordable, adaptable, and environmentally friendly technologies. The chapter imparts lessons from development projects, stressing responsible technology use. Key points include integrating technology into comprehensive strategies tailored to local contexts, selecting suitable over sophisticated tech, diverse development models, and considering maintenance and sustainability. A one-size-fits-all approach is discouraged, urging the inclusion of communities, a bottom-up approach, and addressing inequalities. Technological leapfrogging, allowing less advanced regions to adopt newer technologies directly, is discussed. Considering unique contexts, the passage underscores the importance of culturally sensitive, sustainable technology integration in international development.