The chapter discusses the challenges associated with policymaking based on evidence, emphasizing the need for individuals to become informed consumers of research. It highlights the complexities of science, underscoring that evidence alone cannot dictate policy decisions due to uncertainties, differing interpretations, and the influence of values. The role of media in distorting scientific information is addressed, citing examples like cell phone use and cancer or video game violence. The passage advises readers to be skeptical, check original sources, and consider limitations of research. Conflicts of interest are introduced as potential sources of bias, with transparency and disclosure seen as essential safeguards. The chapter further stresses the importance of discerning the quality of research, considering statistical significance and effect size, understanding random clusters, and addressing issues of reproducibility and replicability. Finally, it discusses the prevalence of scientific misconduct, its impact on public trust, and measures being taken to detect and prevent it, including training, open science practices, and clear policies for addressing allegations.