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Chapter 48 - Rubella

from Section 6 - Viral Infections

Published online by Cambridge University Press:  18 June 2025

David Mabey
Affiliation:
London School of Hygiene and Tropical Medicine
Martin W. Weber
Affiliation:
World Health Organization
Moffat Nyirenda
Affiliation:
London School of Hygiene and Tropical Medicine
Dorothy Yeboah-Manu
Affiliation:
Noguchi Memorial Institute for Medical Research, University of Ghana
Jackson Orem
Affiliation:
Uganda Cancer Institute, Kampala
Laura Benjamin
Affiliation:
University College London
Michael Marks
Affiliation:
London School of Hygiene and Tropical Medicine
Nicholas A. Feasey
Affiliation:
Liverpool School of Tropical Medicine
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Summary

Rubella is an enveloped positive-sense, single-stranded RNA virus and has recently been reclassified into the Matonaviridae family. Although there is only one serotype of rubella virus, various genotypes exist and identification of these can be used to track outbreaks. Humans are the only reservoir and therefore elimination through vaccination is feasible. The virus is transmitted via respiratory secretions and initially multiplies in the respiratory tract before spreading to other organs and producing a viraemia. At the viraemic stage, the virus can cross the placenta and cause a disseminated infection in the developing foetus. The incubation period, from exposure to rash onset, is 14 days (range 12–23 days), and individuals are infective for approximately 7 days before and 7–12 days after the rash has developed (Best 2007). The virus can be destroyed relatively easily by heat, detergents, extremes of pH or ultraviolet light.

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Publisher: Cambridge University Press
Print publication year: 2025

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References

Best, J.M. 2007. Rubella. Seminars in Fetal and Neonatal Medicine, Congenital and Opportunistic Infections 12, 182192. doi.org/10.1016/j.siny.2007.01.017.CrossRefGoogle ScholarPubMed
Best, J.M., Enders, G. 2006. Laboratory diagnosis of rubella and congenital rubella. In Banatvala, J., Peckham, C. (eds) Perspectives in Medical Virology, Rubella Viruses, 3977. Elsevier. doi.org/10.1016/S0168-7069(06)15003-X.CrossRefGoogle Scholar
da Silva e Sá, G.R., Camacho, L.A.B., Siqueira, M.M., Stavola, M.S., Ferreira, D.A. 2006. Seroepidemiological profile of pregnant women after inadvertent rubella vaccination in the state of Rio de Janeiro, Brazil, 2001–2002. Rev Panam Salud Publica 19, 371378. doi.org/10.1590/s1020-49892006000600002.Google Scholar
Patel, M.K., Antoni, S., Danovaro-Holliday, M.C. et al. 2020. The epidemiology of rubella, 2007–18: an ecological analysis of surveillance data. Lancet Global Health 8, e1399e1407. doi.org/10.1016/S2214-109X(20)30320-X.CrossRefGoogle ScholarPubMed
Vynnycky, E., Adams, E.J., Cutts, F.T. et al. 2016. Using seroprevalence and immunisation coverage data to estimate the global burden of congenital rubella syndrome, 1996–2010: a systematic review. PLoS ONE 11, e0149160. doi.org/10.1371/journal.pone.0149160.CrossRefGoogle ScholarPubMed
WHO Regional Office for Africa. 2015. Regional strategic plan for immunization 20142020. www.afro.who.int/publications/regional-strategic-plan-immunization-2014-2020-0.Google Scholar

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