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Chapter 43 - Dengue

from Section 6 - Viral Infections

Published online by Cambridge University Press:  18 June 2025

By
Jolynne Mokaya  and
George M. Warimwe
Edited by
David Mabey ,
Martin W. Weber ,
Moffat Nyirenda ,
Dorothy Yeboah-Manu ,
Jackson Orem ,
Laura Benjamin ,
Michael Marks  and
Nicholas A. Feasey
David Mabey
Affiliation:
London School of Hygiene and Tropical Medicine
Martin W. Weber
Affiliation:
World Health Organization
Moffat Nyirenda
Affiliation:
London School of Hygiene and Tropical Medicine
Dorothy Yeboah-Manu
Affiliation:
Noguchi Memorial Institute for Medical Research, University of Ghana
Jackson Orem
Affiliation:
Uganda Cancer Institute, Kampala
Laura Benjamin
Affiliation:
University College London
Michael Marks
Affiliation:
London School of Hygiene and Tropical Medicine
Nicholas A. Feasey
Affiliation:
Liverpool School of Tropical Medicine
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Summary

Dengue is a mosquito-borne disease whose burden continues to increase globally causing an estimated 20,000 deaths each year (WHO 2021; Zeng et al. 2021). The total number of dengue infections has increased from 23 million in the 1990s to an estimated 100 million in 2017 across more than 110 countries in the WHO regions of Africa, the Americas and Asia; with Asia representing about 70% of the global burden of disease (WHO 2017, 2021; Zeng et al. 2021).

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Principles of Medicine in Africa , pp. 467 - 472
Publisher: Cambridge University Press
Print publication year: 2025

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References

Balakrishnan, T. et al. (2011). Dengue virus activates polyreactive, natural IgG B cells after primary and secondary infection. PloS ONE 6(12). doi.org/10.1371/journal.pone.0029430.CrossRefGoogle ScholarPubMed
Bhatt, P. et al. (2021). Current understanding of the pathogenesis of dengue virus infection. Current Microbiology 78(1):17–32.10.1007/s00284-020-02284-wCrossRefGoogle ScholarPubMed
Carrington, L. B. & Simmons, C. P. (2014). Human to mosquito transmission of dengue viruses. Frontiers in Immunology 5:290. doi.org/10.3389/fimmu.2014.00290.CrossRefGoogle ScholarPubMed
Chen, H. R., Lai, Y. C. & Yeh, T. M. (2018). Dengue virus non-structural protein 1: a pathogenic factor, therapeutic target, and vaccine candidate. Journal of Biomedical Science 25(1):58.10.1186/s12929-018-0462-0CrossRefGoogle ScholarPubMed
Etymologia: dengue. (2006). Centers for Disease Control and Prevention (CDC), Emerging Infectious Diseases 12(6):893.Google Scholar
Fritzell, C. et al. (2018). Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: a scoping review. PLoS Neglected Tropical Diseases 12(7):e0006533.10.1371/journal.pntd.0006533CrossRefGoogle ScholarPubMed
Guzman, M. G. et al. (2010). Dengue: a continuing global threat. Nature Reviews Microbiology 8(12):S7–S16.CrossRefGoogle ScholarPubMed
Hadinegoro, S. R. S. (2012). The revised WHO dengue case classification: does the system need to be modified? Paediatrics and International Child Health 32(s1):33–38.10.1179/2046904712Z.00000000052CrossRefGoogle ScholarPubMed
Halstead, S. M. (2017). Dengue and dengue hemorrhagic fever. In Handbook of Zoonoses, 2nd ed. Section B: Viral Zoonoses, 89–99. Baco Raton: CRC Press.Google Scholar
Jaenisch, T. et al. (2014). Dengue expansion in Africa—not recognized or not happening? Emerging Infectious Diseases 20(10). doi: 10.3201/eid2010.140487.CrossRefGoogle ScholarPubMed
Kuhn, R. J. et al. (2002). Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell 108(5):717–725.CrossRefGoogle ScholarPubMed
Lee, J.-S. et al. (2019). A multi-country study of the economic burden of dengue fever based on patient-specific field surveys in Burkina Faso, Kenya, and Cambodia. PLOS Neglected Tropical Diseases 13(2). doi.org/10.1371/journal.pntd.0007164.CrossRefGoogle Scholar
Nedjadi, T. et al. (2015). Tackling dengue fever: current status and challenges. Virology Journal 12:212.10.1186/s12985-015-0444-8CrossRefGoogle ScholarPubMed
PAHO. (2020). Algorithms for the Clinical Management of Dengue Patients. www.paho.org/en/documents/algorithms-clinical-management-dengue-patients.Google Scholar
Peeling, R. W. et al. (2010). Evaluation of diagnostic tests: dengue. Nature Reviews Microbiology. 8(12):S30–S38.10.1038/nrmicro2459CrossRefGoogle ScholarPubMed
Pinheiro-Michelsen, J. R. et al. (2020). Anti-dengue vaccines: from development to clinical trials. Frontiers in Immunology 11:1252.10.3389/fimmu.2020.01252CrossRefGoogle ScholarPubMed
Rivino, L. et al. (2015). Virus-specific T lymphocytes home to the skin during natural dengue infection. Science Translational Medicine 7(278):278ra35.CrossRefGoogle Scholar
Screaton, G. et al. (2015). New insights into the immunopathology and control of dengue virus infection. Nature Reviews Immunology 15:745–759.10.1038/nri3916CrossRefGoogle ScholarPubMed
Silva, N. M., Santos, N. C. & Martins, I. C. (2020). Dengue and zika viruses: epidemiological history, potential therapies, and promising vaccines. Tropical Medicine and Infectious Disease 5(4). doi: 10.3390/tropicalmed5040150.CrossRefGoogle ScholarPubMed
St. John, A. L. & Rathore, A. P. S. (2019). Adaptive immune responses to primary and secondary dengue virus infections. Nature Reviews Immunology. 19:218–230.10.1038/s41577-019-0123-xCrossRefGoogle ScholarPubMed
Troost, B. & Smit, J. M. (2020). Recent advances in antiviral drug development towards dengue virus. Current Opinion in Virology 43:9–21.10.1016/j.coviro.2020.07.009CrossRefGoogle ScholarPubMed
Warkentien, T. & Pavlicek, R. (2016). Dengue fever: historical perspective and the global response. Journal of Infectious Diseases and Epidemiology 2(2). doi: 10.23937/2474-3658/1510015.CrossRefGoogle Scholar
WHO. (2017). Global vector control response 2017–2030.Google Scholar
WHO. (2021). Dengue and severe dengue.Google Scholar
WHO. (2016). Laboratory testing for Zika virus infection: interim guidance.Google Scholar
Zeng, Z. et al. (2021). Global, regional, and national dengue burden from 1990 to 2017: a systematic analysis based on the global burden of disease study 2017. EClinicalMedicine 32:100712.10.1016/j.eclinm.2020.100712CrossRefGoogle ScholarPubMed

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