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Chapter 29 - Brucellosis

from Section 5 - Bacterial Infections

Published online by Cambridge University Press:  18 June 2025

David Mabey
Affiliation:
London School of Hygiene and Tropical Medicine
Martin W. Weber
Affiliation:
World Health Organization
Moffat Nyirenda
Affiliation:
London School of Hygiene and Tropical Medicine
Dorothy Yeboah-Manu
Affiliation:
Noguchi Memorial Institute for Medical Research, University of Ghana
Jackson Orem
Affiliation:
Uganda Cancer Institute, Kampala
Laura Benjamin
Affiliation:
University College London
Michael Marks
Affiliation:
London School of Hygiene and Tropical Medicine
Nicholas A. Feasey
Affiliation:
Liverpool School of Tropical Medicine
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Summary

Brucellosis is caused by Brucella species acquired by contact with or consumption of raw products from reservoir animals, including camels, cattle, goats, pigs, and sheep. The disease is concentrated among pastoralists who manage large livestock herds (Bodenham et al. 2020), often of mixed species, including in the Sahel and the Horn of Africa.

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Publisher: Cambridge University Press
Print publication year: 2025

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References

Bodenham, R.F., Lukambagire, A.S., Ashford, R.T. et al. (2020) Prevalence and speciation of brucellosis in febrile patients from a pastoralist community of Tanzania. Sci Rep, 10, 7081.10.1038/s41598-020-62849-4CrossRefGoogle ScholarPubMed
Cash-Goldwasser, S., Maze, M.J., Rubach, M.P. et al. (2018) Risk factors for human brucellosis in northern Tanzania. Am J Trop Med Hyg, 98, 598606.CrossRefGoogle ScholarPubMed
Dean, A.S., Crump, L., Greter, H., Schelling, E. & Zinsstag, J. (2012) Global burden of human brucellosis: a systematic review of disease frequency. PLoS Negl Trop Dis, 6, e1865.CrossRefGoogle ScholarPubMed
Gotuzzo, E., Carrillo, C., Guerra, J. & Llosa, L. (1986) An evaluation of diagnostic methods for brucellosis: the value of bone marrow culture. J Infect Dis, 153, 122–5.10.1093/infdis/153.1.122CrossRefGoogle ScholarPubMed
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Makita, K., Fèvre, E.M., Waiswa, C. et al. (2008) Human brucellosis in urban and peri-urban areas of Kampala, Uganda. Ann N Y Acad Sci, 1149, 309–11.10.1196/annals.1428.015CrossRefGoogle Scholar
Pappas, G., Akritidis, N., Bosilkovski, M. & Tsianos, E. (2005) Brucellosis. N Eng J Med, 352, 2325–36.10.1056/NEJMra050570CrossRefGoogle ScholarPubMed
Reddy, E.A., Shaw, A.V. & Crump, J.A. (2010) Community acquired bloodstream infections in Africa: a systematic review and meta-analysis. Lancet Infect Dis, 10, 417–32.10.1016/S1473-3099(10)70072-4CrossRefGoogle Scholar
Yousefi-Nooraie, R., Mortaz-Hejri, S., Mehrani, M. & Sadeghipour, P. (2012) Antibiotics for treating human brucellosis. Cochrane Database Syst Rev, 10, CD007179.Google ScholarPubMed

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