This chapter provides an overview of the emergence of a body of literature that emplots Indigenous material realities and forms of knowledge into Latinx literature’s representational horizon. These texts mark a significant transition, moving away from an understanding of Latinx identity rooted in a mythological Indian past, and focusing instead on a diverse array of issues grounded in Indigenous identities, experiences, and epistemologies. These include explorations of the liberatory potential in transnational feminist solidarities, the thematization of contemporary manifestations of settler colonialism, the foregrounding of land-based knowledge, and the celebration of the creative power and insurgent force of the erotic. Focusing on works by Graciela Limón, Kali Fajardo-Anstine, Natalie Diaz, and Alan Pelaez Lopez, the chapter argues that these writings collectively depict Latinx Indigeneity at the intersections of race, gender, sexuality, and colonialism, raising complex issues with respect to overlapping and ongoing histories of colonization and fostering an opportunity for centering Indigenous experiences while interrogating the multiracial character of Latinidad.