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Chapter 4 - Neoplasms of Cutaneous Appendages

Published online by Cambridge University Press:  17 June 2025

By
Mai P. Hoang
Edited by
Mai P. Hoang
Mai P. Hoang
Affiliation:
Harvard Medical School, Boston
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Summary

Traditionally tumors derived from the cutaneous appendages are classified according to their lines of differentiation: either follicular, sebaceous, eccrine or apocrine. However, there are overlapping histologic features and the classification is far from being straight forward. Often a tumor would exhibit multiple lines of differentiation with features of both eccrine and apocrine and even sebaceous differentiation. In some instances, immunohistochemistry can be of help in distinguishing epidermal from adnexal origin, benign from malignant adnexal neoplasms, and primary adnexal carcinoma from cutaneous metastases.

Keywords

Adnexal carcinomabasal cell carcinomamicrocystic adnexal carcinomaextramammary Paget diseasecutaneous metastasesapocrine carcinoma

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Chapter
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Immunohistochemistry and Ancillary Studies in Diagnostic Dermatopathology , pp. 67 - 111
Publisher: Cambridge University Press
Print publication year: 2025

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