Chapter 8 considers the politics and poetics of alterity or otherness. Others confront us with experiences that may be radically unfamiliar, strange, and unsettling. This may be compounded by illness, trauma, and cultural difference. With empathy and imagination, we can gain an understanding of another’s experience, see their perspective, and build a picture of their predicament. The imaginative spaces and places in their stories offer us a way into another’s lifeworld—even when that world is profoundly different from our own. Narrative medicine provides a pedagogy of empathic understanding through literature. While much of this work employs story, lyric poetry offers another mode of articulating illness experience that may be closer to patients’ emotionally charged, confused efforts to make sense of experiences that do not fit cultural models or templates. The work of the poets Paul Celan and Edouard Glissant sheds light on the power of language to bridge disparate worlds and on the ethical stance needed when empathy fails. A poetics of alterity has implications for efforts to understand individuals’ illness experience and grounding an ethics of care.