Chapter 1 provides an overview of the central argument of the book. Medical anthropology, psychology, and psychiatry must steer a course between realism and constructivism, integrating the useful features of both perspectives. Metaphor theory and 4-E cognitive science provide ways of integrating cognitive and socio-cultural processes. Metaphor production and comprehension involves cognitive and emotional processes embodied and enacted through rhetoric and social discourse. These practices constitute a hermeneutic circle that can be traced from body to person to social world and back. They show how symbols and things live in the same world. This work has implications for understanding the ways illness experience and healing practices are embedded in larger systems of knowledge/power. The metaphors that arise in individuals’ struggles to make sense of their predicaments and to heal from affliction are borrowed from everyday concepts of mind and body, as well as the political language of power, resistance, and dissent. Every metaphor lends power to a particular view of the world. We must judge the value of metaphors on their moral, political, aesthetic, and pragmatic implications.