The chapter sets out a framework for understanding the manifold crisis of the human–planetary condition. It argues that this crisis condition goes far beyond the climate crisis. Most critics tend to focus on particular issues or measurable trends rather than the abnegations of human and planetary flourishing. More pointedly, the accumulating literature rarely addresses the grounding conditions of the crisis condition nor its broader consequences for being human. Rarely do commentators set out clear pathways to the alternative possibilities. Accordingly, this chapter explores three main processes as shifting the terms of the human condition: abstraction, reconstitution, and unsettling. First, it suggests that we are materially abstracting social life, fundamentally remaking relations between people, and between persons and their worlds. Second, we are reconstituting the elements of nature and culture, including our own nature and the dominant forms of social life. And third, we are relativising the deepest structures of human practice and meaning in such ways as to change the nature of our social being. This confluence adds up to a great unsettling of the human condition.