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Chapter 1.5 - Haematological

from Section 1 - Medicine

Published online by Cambridge University Press:  26 May 2025

Edited by
Rebecca Leslie ,
Emily Johnson ,
Gary Thomas  and
Philip Harrington
Rebecca Leslie
Affiliation:
Royal United Hospitals NHS Foundation Trust, Bath
Emily Johnson
Affiliation:
Worcester Acute Hospitals NHS Trust, Worcester
Gary Thomas
Affiliation:
Cwm Taf Morgannwg University Health Board, Bridgend
Philip Harrington
Affiliation:
West Midlands Deanery, Birmingham
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Summary

Blood groups result from different antigens expressed on the surface of red blood cells (RBCs). There are a number of different blood group antigens, and those produced by the same gene are called a blood group system. Two of the most important blood group systems are the ABO system and the Rhesus (Rh) system as these are the main systems responsible for transfusion compatibility. However, these are only 2 of 29 blood group systems which have currently been identified. Examples of other systems are the Kell, Kidd, Lutheran and Duffy systems. The importance of these other blood groups systems should not be underestimated.

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Dr Podcast Scripts for the Final FRCA , pp. 122 - 157
Publisher: Cambridge University Press
Print publication year: 2025

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References

Further Reading

Association of Anaesthetists of Great Britain and Ireland (AoA) Guidelines: The use of blood components and their alternatives. Anaesthesia. 2016; 71(7);829–842.Google Scholar
British Committee for Standards in Haematology (BCSH). Guideline on the Administration of Blood Components. First published 2009. www.bcshguidelines.com/4HAEMATOLOGYGUIDELINES.html?dtype=Transfusion&dpage=0&sspage=0&ipage=0.Google Scholar
Kirkman, E. Blood groups. Anaesthesia and Intensive Care. 2010; 11(6): 232–235.CrossRefGoogle Scholar
Mugabe, B et al. Serious hazards of transfusion (SHOT): Its implications for intensive care Journal of the Intensive Care Society. 2013; 14(3): 215–219.CrossRefGoogle Scholar

Further Reading

Herbert, P, Wells, G, Blajchman, M et al. A Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care. New England Journal of Medicine. 1999; 340: 409–417.CrossRefGoogle Scholar
NICE blood transfusion guidelines. 2015.Google Scholar
Stoddard, K, Sohal, M, Bedson, R. Anaesthetic management of patients with sickle cell disease in obstetrics. British Journal of Anaesthesia Education. 2022; 22(3): P87–93.Google ScholarPubMed

Further Reading

Blood Transfusion and the Anaesthetist - Red Cell Transfusion 2. Association of Anaesthetists. 2008.Google Scholar
Devereaux, P, Marcucci, M, Painter, T. Tranexamic acid in patients undergoing noncardiac surgery New England Journal of Medicine. 2022; 386: 1986–1997.CrossRefGoogle ScholarPubMed
Hebert, PC, Wells, G, Blajchman, MA et al. Canadian Critical Care Trials Group. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. New England Journal of Medicine. 1999; 340: 409–417.CrossRefGoogle ScholarPubMed
Hill, SR, Carless, PA, Henry, DA et al. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database of Systematic Reviews 2000.CrossRefGoogle Scholar
Horlocker, T et al. Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (Third Edition) Regional Anesthesia and Pain Medicine: January/February 2010; 35 (1): 64–101CrossRefGoogle ScholarPubMed
Shah, U, Narayanan, M, Smith, J. Anaesthetic considerations in patients with inherited disorders of coagulation. BJA Education. 2014; available from https://academic.oup.com/bjaed/article/15/1/26/257411CrossRefGoogle Scholar
www.transfusionguidelines.org.uk/docs/pdfs/htm_edition-4_all-pages.pdfGoogle Scholar
Stainsby, D, MacLennan, S, Thomas, D, Isaac, J, Hamilton, PJ. Guidelines on the management of massive blood loss. British Journal of Haematology. 2006; 135: 634–641.Google ScholarPubMed

Further Reading

Howard-Alpe, GM, de Bono, J, Hudsmith, L, et al. Coronary artery stents and non-cardiac surgery. British Journal of Anaesthesia. 2007; 98(5): 560–574.CrossRefGoogle ScholarPubMed
Keeling, D, Campbell, TR, Watson, H. Association of Anaesthetists of Great Britain and Ireland, Obstetric Anaesthetists’ Association and Regional Anaesthesia UK. Regional anaesthesia and patients with abnormalities of coagulation. Anaesthesia. 2013; 68: 966–972.Google Scholar
Peri-operative management of anti-coagulant and anti-platelet therapy. British Journal of Haematology. 2016; 175: 602–613.CrossRefGoogle Scholar

Further Reading

Barker, RC Marval, P et al. Venous thromboembolism: Risks and prevention Continuing Education in Anaesthesia, Critical Care and Pain. 2011; 11 (1): 18–23.CrossRefGoogle Scholar
Jaff, MR et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: A scientific statement from the American Heart Association. Circulation. 2011; 123 (16): 1788–830.CrossRefGoogle ScholarPubMed
Luff, D. et al. Fat embolism syndrome British Journal of Anaesthesia Education. 21 (9): 322–328.CrossRefGoogle Scholar
National Institute of Clinical Excellence Clinical Guideline 46. Venous Thromboembolism: Reducing the Risk of Venous Thromboembolism in Inpatients Undergoing Surgery. National Institute for Health and Clinical Excellence, 2007 www.nice.org.uk/guidance/CG92.Google Scholar
National Institute of Clinical Excellence Guideline 158 Venous thromboembolic diseases: Diagnosis, management and thrombophilia testing www.nice.org.uk/guidance/ng158.Google Scholar

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  • Haematological
  • Edited by Rebecca Leslie, Royal United Hospitals NHS Foundation Trust, Bath, Emily Johnson, Worcester Acute Hospitals NHS Trust, Worcester, Gary Thomas, Cwm Taf Morgannwg University Health Board, Bridgend, Philip Harrington, West Midlands Deanery, Birmingham
  • Book: Dr Podcast Scripts for the Final FRCA
  • Online publication: 26 May 2025
  • Chapter DOI: https://doi.org/10.1017/9781009267441.006
Available formats
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  • Haematological
  • Edited by Rebecca Leslie, Royal United Hospitals NHS Foundation Trust, Bath, Emily Johnson, Worcester Acute Hospitals NHS Trust, Worcester, Gary Thomas, Cwm Taf Morgannwg University Health Board, Bridgend, Philip Harrington, West Midlands Deanery, Birmingham
  • Book: Dr Podcast Scripts for the Final FRCA
  • Online publication: 26 May 2025
  • Chapter DOI: https://doi.org/10.1017/9781009267441.006
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Haematological
  • Edited by Rebecca Leslie, Royal United Hospitals NHS Foundation Trust, Bath, Emily Johnson, Worcester Acute Hospitals NHS Trust, Worcester, Gary Thomas, Cwm Taf Morgannwg University Health Board, Bridgend, Philip Harrington, West Midlands Deanery, Birmingham
  • Book: Dr Podcast Scripts for the Final FRCA
  • Online publication: 26 May 2025
  • Chapter DOI: https://doi.org/10.1017/9781009267441.006
Available formats
×