Abstract: Medicine improved since the beginning of Anne’s career. Therapies improved for neurological illnesses such as Parkinson’s disease, epilepsy, multiple sclerosis, myasthenia gravis and others. Improvements can be made in the time doctors have to spend on paperwork and extensive documentation required by insurance companies that leave less time for actual patient interactions. There are still challenges for women, such as their promotion to the highest academic and leadership levels. Anne describes the advances since her early studies in Sol’s lab. By 2015, it was becoming impossible for Anne to deny Nancy’s signs of HD. Anne wanted so much to help her. Nancy’s sister, Alice, became a close friend and they both hoped Nancy would join a clinical trial. Several promising therapies were being tested and Nancy agreed to join one. Before she was able to actually join the trial, however, it was suddenly stopped as it was making people worse. Over weekly Zoom calls with Anne and Alice, Nancy was excited that her Hereditary Disease Foundation (HDF) was going to fund three large and extremely innovative research grants that promise the application of novel approaches to find HD therapies.