Abstract: Anne officially finished her required clerkships in just nine months by the end of December 1971. After creating a combined MD and PhD degree, she officially became the first MD/PhD graduate student to work in Sol Snyder’s lab. The combined degree program provided tools to work at the interface between basic research and clinical patient care. Throughout Anne’s time at Johns Hopkins, she noticed a certain type of confidence the male students had, even if they were inaccurate. Sol put Anne on a project to determine whether homocarnosine was a neurotransmitter. Anne was hit by a car. She was in the ER and eventually the ICU due to fat emboli. The senior neurologist at Johns Hopkins told Jack that Anne had a 25–50 percent chance of survival. She was given large doses of steroids and survived. Within five weeks of her accident, Anne was back at the lab. Her enthusiasm for the homocarnosine project had waned because it was unlikely to be a neurotransmitter. Anne met fellow graduate student Candace Pert. Their lab benches were across from one another. Pert discovered a new method to measure opiate receptors in the brain.