Cyril of Alexandria was a central figure in many of the theological developments and religious conflicts that challenged the stability of the fifth-century eastern Roman Empire. Crucial moments during his episcopacy (412–44) marking wider and more complex developments may be seen with sharp clarity in the outbreaks of overt violence between Christians and Jews and between Christians and “pagans” in the metropolis of Alexandria during the first years of his episcopal career. Moreover, roughly halfway through his tenure as bishop, he would involve himself in a doctrinal dispute underway in the eastern capital of Constantinople, opposing its bishop Nestorius because he believed the truth of the gospel was dangerously undermined by what he took to be Nestorius’ errant Christology. Through the savvy manipulation of ecclesiastical and imperial politics, Cyril succeeded in having Nestorius deposed by the Council of Ephesus in 431, though it took eighteenth months of negotiations to restore communion between the warring factions.