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Part II - Underlying biological substrates associated with cognitive dysfunction in major depressive disorder

Published online by Cambridge University Press:  05 March 2016

Edited in association with
Roger S. McIntyre
Affiliation:
University of Toronto
Danielle S. Cha
Affiliation:
University of Toronto
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Cognitive Impairment in Major Depressive Disorder
Clinical Relevance, Biological Substrates, and Treatment Opportunities
, pp. 145 - 228
Publisher: Cambridge University Press
Print publication year: 2016

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References

American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (5th edn.). Arlington, VA: American Psychiatric Publishing.Google Scholar
Amico, F., Carballedo, A., Lisiecka, D., Fagan, A. J., Boyle, G., & Frodl, T. (2012). Functional anomalies in healthy individuals with a first degree family history of major depressive disorder. Biology of Mood & Anxiety Disorders, 2(1): 1.CrossRefGoogle ScholarPubMed
Austin, M. P., Mitchell, P., & Goodwin, G. M. (2001). Cognitive deficits in depression: Possible implications for functional neuropathology. British Journal of Psychiatry, 178(3): 200206.CrossRefGoogle ScholarPubMed
Barch, D. M., Sheline, Y. I., Csernansky, J. G., & Snyder, A. Z. (2003). Working memory and prefrontal cortex dysfunction: Specificity to schizophrenia compared with major depression. Biological Psychiatry, 53(5): 376384.CrossRefGoogle ScholarPubMed
Beblo, T., Baumann, B., Bogerts, B., Wallesch, C.-W., & Herrmann, M. (1999). Neuropsychological correlates of major depression: A short-term follow-up. Cognitive Neuropsychiatry, 4(4): 333341.CrossRefGoogle Scholar
Beck, A. T. (2008). The evolution of the cognitive model of depression and its neurobiological correlates. American Journal of Psychiatry, 165(8): 969977.CrossRefGoogle ScholarPubMed
Berman, K. F., Doran, A. R., Pickar, D., & Weinberger, D. R. (1993). Is the mechanism of prefrontal hypofunction in depression the same as in schizophrenia? Regional cerebral blood flow during cognitive activation. British Journal of Psychiatry, 162(2): 183192.CrossRefGoogle Scholar
Bhagwagar, Z., Cowen, P. J., Goodwin, G. M., & Harmer, C. J. (2004). Normalization of enhanced fear recognition by acute SSRI treatment in subjects with a previous history of depression. American Journal of Psychiatry, 161(1): 166168.CrossRefGoogle ScholarPubMed
Bhardwaj, A., Wilkinson, P., Srivastava, C., & Sharma, M. (2010). Cognitive deficits in euthymic patients with recurrent depression. Journal of Nervous and Mental Disease, 198(7): 513515.CrossRefGoogle ScholarPubMed
Biringer, E., Mykletun, A., Sundet, K., Kroken, R., Stordal, K. I., & Lund, A. (2007). A longitudinal analysis of neurocognitive function in unipolar depression. Journal of Clinical and Experimental Neuropsychology, 29(8): 879891.CrossRefGoogle ScholarPubMed
Burt, D. B., Zembar, M. J., & Niederehe, G. (1995). Depression and memory impairment: A meta-analysis of the association, its pattern, and specificity. Psychological Bulletin, 117(2): 285305.CrossRefGoogle ScholarPubMed
Chan, S. W. Y., Goodwin, G. M., & Harmer, C. J. (2007). Highly neurotic never-depressed students have negative biases in information processing. Psychological Medicine, 37(9): 12811291.CrossRefGoogle ScholarPubMed
Christensen, M. V., Kyvik, K. O., & Kessing, L. V. (2006). Cognitive function in unaffected twins discordant for affective disorder. Psychological Medicine, 36(8): 11191129.CrossRefGoogle ScholarPubMed
Costafreda, S. G., Brammer, M., David, A. S., & Fu, C. H. Y. (2008). Predictors of amygdala activation during the processing of emotional stimuli: A meta-analysis of 385 PET and fMRI studies. Brain Research Reviews, 58(1): 5770.CrossRefGoogle ScholarPubMed
Davidson, R. (2000). Affective style, psychopathology, and resilience: Brain mechanisms and plasticity. American Psychologist, 55(11): 11961214.CrossRefGoogle ScholarPubMed
Disner, S. G., Beevers, C. G., Haigh, E. A. P., & Beck, A. T. (2011). Neural mechanisms of the cognitive model of depression. Nature Reviews Neuroscience, 12(8): 467477.CrossRefGoogle ScholarPubMed
Douglas, K. M. & Porter, R. J. (2009). Longitudinal assessment of neuropsychological function in major depression. Australian and New Zealand Journal of Psychiatry, 43(12): 11051117.CrossRefGoogle ScholarPubMed
Douglas, K. M., Porter, R. J., Knight, R. G., & Maruff, P. (2011). Neuropsychological changes and treatment response in severe depression. British Journal of Psychiatry, 198(2): 115122.CrossRefGoogle ScholarPubMed
Egan, M. F., Kojima, M., Callicott, J. H., Goldberg, T. E., Kolachana, B. S., Bertolino, A., … Weinberger, D. R. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112(2): 257269.CrossRefGoogle ScholarPubMed
Foland-Ross, L. C. & Gotlib, I. H. (2012). Cognitive and neural aspects of information processing in major depressive disorder: An integrative perspective. Frontiers in Psychology, 3: 489.CrossRefGoogle ScholarPubMed
Frodl, T., Meisenzahl, E. M., Zetzsche, T., Born, C., Groll, C., Jager, M., … Moller, H J. (2002). Hippocampal changes in patients with a first episode of major depression. American Journal of Psychiatry, 159(7): 11121118.CrossRefGoogle ScholarPubMed
Glahn, D. C., Curran, J. E., Winkler, A. M., Carless, M. A., Kent, J. W., Charlesworth, J. C., … Blangero, J. (2012). High dimensional endophenotype ranking in the search for major depression risk genes. Biological Psychiatry, 71(1): 614.CrossRefGoogle ScholarPubMed
Gollan, J. K., Pane, H. T., McCloskey, M. S., & Coccaro, E. F. (2008). Identifying differences in biased affective information processing in major depression. Psychiatry Research, 159(1–2): 1824.CrossRefGoogle ScholarPubMed
Gorwood, P., Corruble, E., Falissard, B., & Goodwin, G. M. (2008). Toxic effects of depression on brain function: Impairment of delayed recall and the cumulative length of depressive disorder in a large sample of depressed outpatients. American Journal of Psychiatry, 165(6): 731739.CrossRefGoogle Scholar
Gotlib, I. H. & Joormann, J. (2010). Cognition and depression: Current status and future directions. Annual Review of Clinical Psychology, 27(6): 285312.CrossRefGoogle Scholar
Gottesman, I. I. & Gould, T. D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry, 160(4): 636645.CrossRefGoogle ScholarPubMed
Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., … Schatzberg, A. F. (2007). Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus. Biological Psychiatry, 62(5): 429437.CrossRefGoogle ScholarPubMed
Gualtieri, C. T., Johnson, L. G., & Benedict, K. B. (2006). Neurocognition in depression: Patients on and off medication versus healthy comparison subjects. Journal of Neuropsychiatry and Clinical Neurosciences, 18(2): 217225.CrossRefGoogle ScholarPubMed
Hariri, A. R., Goldberg, T. E., Mattay, V. S., Kolachana, V. S., Callicott, J. H., Egan, M. F., & Weinberger, D. R. (2003). Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance. Journal of Neuroscience, 23(17): 66906694.CrossRefGoogle ScholarPubMed
Hasler, G., Drevets, W. C., Manji, H. K., & Charney, D. S. (2004). Discovering endophenotypes for major depression. Neuropsychopharmacology, 29(10): 17651781.CrossRefGoogle ScholarPubMed
Hasselbalch, B. J., Knorr, U., Hasselbalch, S. G., Gade, A., & Kessing, L. V. (2012). Cognitive deficits in the remitted state of unipolar depressive disorder. Neuropsychology, 26(5): 642651.CrossRefGoogle ScholarPubMed
Herrera-Guzmán, I., Gudayol-Ferré, E., Herrera-Abarca, J. E., Herrera-Guzmán, D., Montelongo-Pedraza, P., Padrós Blázquez, F., … Guàrdia-Olmos, J. (2010). Major depressive disorder in recovery and neuropsychological functioning: Effects of selective serotonin reuptake inhibitor and dual inhibitor depression treatments on residual cognitive deficits in patients with major depressive disorder in recovery. Journal of Affective Disorders, 123(1–3): 341350.CrossRefGoogle ScholarPubMed
Hollon, S. D., Shelton, S. C., Wisniewski, S., Warden, D., Biggs, M. M., Friedman, E. S., … Rush, A. J. (2006). Presenting characteristics of depressed outpatients as a function of recurrence: Preliminary findings from the STAR*D clinical trial. Journal of Psychiatric Research, 40(1): 5969.CrossRefGoogle ScholarPubMed
Huxley, T. H. H. (1874). On the hypothesis that animals are automata, and its history, Fortnightly Review, NS 16: 555580.Google Scholar
Iris, F. (2008). Biological modeling in the discovery and validation of cognitive dysfunctions biomarkers. In Turck, C. (ed.), Biomarkers for Psychiatric Disorders (pp. 473522). Boston, MA: Springer.Google Scholar
Joormann, J. & Gotlib, I. H. (2006). Is this happiness I see? Biases in the identification of emotional facial expressions in depression and social phobia. Journal of Abnormal Psychology, 115(4): 705714.CrossRefGoogle ScholarPubMed
Kennedy, S. H., Downar, J., Evans, K. R., Feilotter, H., Lam, R. W., MacQueen, G. M., … Soares, C. (2012). The Canadian Biomarker Integration Network in Depression (CAN-BIND): Advances in response prediction. Current Pharmaceutical Design, 18(36): 59765989.CrossRefGoogle ScholarPubMed
Koenen, K. C., Moffitt, T. E., Roberts, A. L., Martin, L. T., Kubzansky, L., Harrington, H., … Caspi, A. (2009). Childhood IQ and adult mental disorders: A test of the cognitive reserve hypothesis. American Journal of Psychiatry, 166(1): 5057.CrossRefGoogle ScholarPubMed
Labermaier, C., Masana, M., & Müller, M. B. (2013). Biomarkers predicting antidepressant treatment response: How can we advance the field? Disease Markers, 35(1): 2331.CrossRefGoogle ScholarPubMed
Landrø, N. I., Stiles, T. C., & Sletvold, H. (2001). Neuropsychological function in nonpsychotic unipolar major depression. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 14(4): 233240.Google ScholarPubMed
Lazarus, R. S. (1984). On the primacy of cognition. American Psychologist, 39(2): 124129.CrossRefGoogle Scholar
Lee, R. S. C., Hermens, D. F., Porter, M. A., & Redoblado-Hodge, M. A. (2012). A meta-analysis of cognitive deficits in first-episode major depressive disorder. Journal of Affective Disorders, 140(2): 113124.CrossRefGoogle ScholarPubMed
LeMoult, J., Joormann, J., Sherdell, L., Wright, Y., & Gotlib, I. H. (2009). Identification of emotional facial expressions following recovery from depression. Journal of Abnormal Psychology, 118(4): 828833.CrossRefGoogle ScholarPubMed
Leppänen, J. M., Milders, M., Bell, J. S., Terriere, E., & Hietanen, J. K. (2004). Depression biases the recognition of emotionally neutral faces. Psychiatry Research, 128(2): 123133.CrossRefGoogle ScholarPubMed
Leuchter, A. F., Cook, I. A., Hamilton, S. P., Narr, K. L., Toga, A., Hunter, A. M., … Lebowitz, B. D. (2010). Biomarkers to predict antidepressant response. Current Psychiatry Reports, 12(6), 553562.CrossRefGoogle ScholarPubMed
Lisiecka, D. M., Carballedo, A., Fagan, A. J., Connolly, G., Meaney, J., & Frodl, T. (2012). Altered inhibition of negative emotions in subjects at family risk of major depressive disorder. Journal of Psychiatric Research, 46(2): 181188.CrossRefGoogle ScholarPubMed
Luby, J. L., Barch, D. M., Belden, A., Gaffrey, M. S., Tillman, R., Babb, C., … Botteron, K. N. (2012). Maternal support in early childhood predicts larger hippocampal volumes at school age. Proceedings of the National Academy of Sciences of the United States of America, 109(8): 28542859.CrossRefGoogle ScholarPubMed
Maalouf, F. T., Brent, D., Clark, L., Tavitian, L., McHugh, R. M., Sahakian, B. J., & Phillips, M. L. (2011). Neurocognitive impairment in adolescent major depressive disorder: state vs. trait illness markers. Journal of Affective Disorders, 133(3): 625632.CrossRefGoogle ScholarPubMed
MacQueen, G. M., Galway, T. M., Hay, J., Young, L. T., & Joffe, J. T. (2002). Recollection memory deficits in patients with major depressive disorder predicted by past depressions but not current mood state or treatment status. Psychological Medicine, 32(2): 251258.CrossRefGoogle ScholarPubMed
Majer, M., Ising, M., Künzel, H., Binder, E. B., Holsboer, F., & Modell, S. (2004). Impaired divided attention predicts delayed response and risk to relapse in subjects with depressive disorders. Psychological Medicine, 34(8): 14531463.CrossRefGoogle ScholarPubMed
Mannie, Z. N., Harmer, C. J., Cowen, P. J., & Norbury, R. (2010). A functional magnetic resonance imaging study of verbal working memory in young people at increased familial risk of depression. Biological Psychiatry, 67(5): 471477.CrossRefGoogle Scholar
Marvel, C. L. & Paradiso, S. (2004). Cognitive and neurological impairment in mood disorders. Psychiatric Clinics of North America, 27(1): 1936, vii–viii.CrossRefGoogle ScholarPubMed
McDermott, L. M. & Ebmeier, K. P. (2009). A meta-analysis of depression severity and cognitive function. Journal of Affective Disorders, 119(1–3): 18.CrossRefGoogle ScholarPubMed
McIntyre, R. S., Cha, D. S., Soczynska, J. K., Woldeyohannes, H. O., Gallaugher, L. A., Kudlow, P., … Baskaran, A. (2013). Cognitive deficits and functional outcomes in major depressive disorder: determinants, substrates, and treatment interventions. Depression and Anxiety, 30(6): 515527.CrossRefGoogle ScholarPubMed
McIntyre, R. S., Lophaven, S., & Olsen, C. K. (2014). A randomized, double-blind, placebo-controlled study of vortioxetine on cognitive function in depressed adults. International Journal of Neuropsychopharmacology, 17(10): 15571567.CrossRefGoogle ScholarPubMed
Meneses, A. (1999). 5-HT system and cognition. Neuroscience and Biobehavioral Reviews, 23(8): 11111125.CrossRefGoogle ScholarPubMed
Millan, M. J., Agid, Y., Brüne, M., Bullmore, E. T., Carter, C. S., Clayton, N. S., … Young, L. J. (2012). Cognitive dysfunction in psychiatric disorders: Characteristics, causes and the quest for improved therapy. Nature Reviews Drug Discovery, 11(2): 141168.CrossRefGoogle ScholarPubMed
Neu, P., Kiesslinger, U., Schlattmann, P., & Reischies, F. M. (2001). Time-related cognitive deficiency in four different types of depression. Psychiatry Research, 103(2–3): 237247.CrossRefGoogle ScholarPubMed
Paelecke-Habermann, Y., Pohl, J., & Leplow, B. (2005). Attention and executive functions in remitted major depression patients. Journal of Affective Disorders, 89(1–3): 125135.CrossRefGoogle ScholarPubMed
Papakostas, G. I. (2014). Cognitive symptoms in patients with major depressive disorder and their implications for clinical practice. Journal of Clinical Psychiatry, 75(1): 814.CrossRefGoogle ScholarPubMed
Perlstein, W. M., Elbert, T., & Stenger, V. A. (2002). Dissociation in human prefrontal cortex of affective influences on working memory-related activity. Proceedings of the National Academy of Sciences of the United States of America, 99(3): 17361741.CrossRefGoogle Scholar
Pessoa, L. (2008). On the relationship between emotion and cognition. Nature Reviews Neuroscience, 9: 148158.CrossRefGoogle ScholarPubMed
Peterson, B. S. & Weissman, M. M. (2011). A brain-based endophenotype for major depressive disorder. Annual Review of Medicine, 62: 461474.CrossRefGoogle ScholarPubMed
Ramel, W., Goldin, P. R., Eyler, L. T., Brown, G. G., Gotlib, I. H., & McQuaid, J. R. (2007). Amygdala reactivity and mood-congruent memory in individuals at risk for depressive relapse. Biological Psychiatry, 61(2): 231239.CrossRefGoogle ScholarPubMed
Raskin, J., Wiltse, C. G., Siegal, A., Sheikh, J., Xu, J., Dinkel, J. J., … Mohs, R. C. (2007). Efficacy of duloxetine on cognition, depression, and pain in elderly patients with major depressive disorder. American Journal of Psychiatry, 164(6): 900909.CrossRefGoogle ScholarPubMed
Reppermund, S., Ising, M., Lucae, S., & Zihl, J. (2009). Cognitive impairment in unipolar depression is persistent and non-specific: Further evidence for the final common pathway disorder hypothesis. Psychological Medicine, 39(4): 603614.CrossRefGoogle ScholarPubMed
Rock, P. L., Roiser, J. P., Riedel, W. J., & Blackwell, A. D. (2014). Cognitive impairment in depression: A systematic review and meta-analysis. Psychological Medicine, 44(10): 20292040.CrossRefGoogle ScholarPubMed
Roiser, J. P. & Sahakian, B. J. (2013). Hot and cold cognition in depression. CNS Spectrums, 18(3): 139149.CrossRefGoogle ScholarPubMed
Sarosi, A., Gonda, X., Balogh, G., Domotor, E., Szekely, A., Hejjas, K., … Faludi, G. (2008). Association of the STin2 polymorphism of the serotonin transporter gene with a neurocognitive endophenotype in major depressive disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 32(7): 16671672.CrossRefGoogle ScholarPubMed
Schlaepfer, T. E., Bewernick, B. H., Kayser, S., Mädler, B., & Coenen, V. A. (2013). Rapid effects of deep brain stimulation for treatment-resistant major depression. Biological Psychiatry, 73(12): 12041212.CrossRefGoogle ScholarPubMed
Schmidt, H. D., Shelton, R. C., & Duman, R. S. (2011). Functional biomarkers of depression: Diagnosis, treatment, and pathophysiology. Neuropsychopharmacology, 36(12): 23752394.CrossRefGoogle ScholarPubMed
Siegle, G. J., Steinhauer, S. R., Thase, M. E., Stenger, V. A., & Carter, C. S. (2002). Can’t shake that feeling: Event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biological Psychiatry, 51(9): 693707.CrossRefGoogle ScholarPubMed
Sumner, J. A., Griffith, J. W., & Mineka, S. (2010). Overgeneral autobiographical memory as a predictor of the course of depression: A meta-analysis. Behaviour Research and Therapy, 48(7): 614625.CrossRefGoogle ScholarPubMed
Surguladze, S. A., Young, A. W., Senior, C., Brébion, G., Travis, M. J., & Phillips, M. L. (2004). Recognition accuracy and response bias to happy and sad facial expressions in patients with major depression. Neuropsychology, 18(2): 212218.CrossRefGoogle ScholarPubMed
Tarbuck, A. F. & Paykel, E. S. (1995). Effects of major depression on the cognitive function of younger and older subjects. Psychological Medicine, 25(2): 285295.CrossRefGoogle ScholarPubMed
Teicher, M. H., Anderson, C. M., & Polcari, A. (2012). Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum. Proceedings of the National Academy of Sciences of the United States of America, 109(9): E563E572.Google ScholarPubMed
Trichard, C., Martinot, J. L., Alagille, M., Masure, M. C., Hardy, P., Ginestet, D., & Féline, A. (1995). Time course of prefrontal lobe dysfunction in severely depressed in-patients: A longitudinal neuropsychological study. Psychological Medicine, 25(1): 7985.CrossRefGoogle ScholarPubMed
Van Oostrom, I., Franke, B., Vasquez, A. A., Rinck, M., Tendolkar, I., Verhagen, M., … Janzing, J. G. E. (2013). Never-depressed females with a family history of depression demonstrate affective bias. Psychiatry Research, 205(1–2): 5458.CrossRefGoogle ScholarPubMed
Weiland-Fiedler, P., Erickson, K., Waldeck, T., Luckenbaugh, D. A., Pike, D., Bonne, O., … Neumeister, A. (2004). Evidence for continuing neuropsychological impairments in depression. Journal of Affective Disorders, 82(2): 253258.CrossRefGoogle ScholarPubMed

References

Andreasen, N. C. (1997). Linking mind and brain in the study of mental illnesses: A project for a scientific psychopathology. Science, 275(5306): 15861593.CrossRefGoogle Scholar
Anisman, H., Kokkinidis, L., & Merali, Z. (2002). Further evidence for the depressive effects of cytokines: Anhedonia and neurochemical changes. Brain, Behavior, and Immunity, 16(5): 544556.CrossRefGoogle ScholarPubMed
Austin, M. P., Mitchell, P., Wilhelm, K., Parker, G., Hickie, I., Brodaty, H., … Hadzi-Pavlovic, D. (1999). Cognitive function in depression: A distinct pattern of frontal impairment in melancholia? Psychological Medicine, 29(1): 7385.CrossRefGoogle ScholarPubMed
Austin, M. P., Ross, M., Murray, C., O’Carroll, R. E., Ebmeier, K. P., & Goodwin, G. M. (1992). Cognitive function in major depression. Journal of Affective Disorders, 25(1): 2129.CrossRefGoogle ScholarPubMed
Bailey, D. J., Kim, J. J., Sun, W., Thompson, R. F., & Helmstetter, F. J. (1999). Acquisition of fear conditioning in rats requires the synthesis of mRNA in the amygdala. Behavioral Neuroscience, 113(2): 276282.CrossRefGoogle ScholarPubMed
Baron, R., Nemirovsky, A., Harpaz, I., Cohen, H., Owens, T., & Monsonego, A. (2008). IFN-gamma enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer’s disease. FASEB Journal, 22(8): 28432852.CrossRefGoogle Scholar
Baune, B. (2009). Conceptual challenges of a tentative model of stress-induced depression. PLoS One, 4(1): e4266.CrossRefGoogle ScholarPubMed
Baune, B. T., Czira, M. E., Smith, A. L., Mitchell, D., & Sinnamon, G. (2012a). Neuropsychological performance in a sample of 13–25 year olds with a history of non-psychotic major depressive disorder. Journal of Affective Disorders, 141(2–3): 441448.CrossRefGoogle Scholar
Baune, B. T., Dannlowski, U., Domschke, K., Janssen, D. G., Jordan, M. A., Ohrmann, P., … Suslow, T. (2010a). The interleukin 1 beta (IL1B) gene is associated with failure to achieve remission and impaired emotion processing in major depression. Biological Psychiatry, 67(6): 543549.CrossRefGoogle ScholarPubMed
Baune, B. T., Konrad, C., Grotegerd, D., Suslow, T., Birosova, E., Ohrmann, P., … Dannlowski, U. (2012b). Interleukin-6 gene (IL-6): a possible role in brain morphology in the healthy adult brain. Journal of Neuroinflammation, 9: 125.CrossRefGoogle ScholarPubMed
Baune, B. T., Konrad, C., Grotegerd, D., Suslow, T., Ohrmann, P., Bauer, J., … Dannlowski, U. (2012c). Tumor necrosis factor gene variation predicts hippocampus volume in healthy individuals. Biological Psychiatry, 72(8): 655662.CrossRefGoogle ScholarPubMed
Baune, B. T., Li, X., & Beblo, T. (2013). Short- and long-term relationships between neurocognitive performance and general function in bipolar disorder. Journal of Clinical and Experimental Psychology, 35(7): 759774.Google Scholar
Baune, B. T., Miller, R., McAfoose, J., Johnson, M., Quirk, F., & Mitchell, D. (2010b). The role of cognitive impairment in general functioning in major depression. Psychiatry Research, 176(2–3): 183189.CrossRefGoogle ScholarPubMed
Baune, B. T., Ponath, G., Golledge, J., Varga, G., Arolt, V., Rothermundt, M., & Berger, K. (2008a). Association between IL-8 cytokine and cognitive performance in an elderly general population: The MEMO-Study. Neurobiology of Aging, 29(6): 937944.CrossRefGoogle Scholar
Baune, B. T., Ponath, G., Rothermundt, M., Riess, O., Funke, H., & Berger, K. (2008b). Association between genetic variants of IL-1beta, IL-6 and TNF-alpha cytokines and cognitive performance in the elderly general population of the MEMO-study. Psychoneuroendocrinology, 33(1): 6876.CrossRefGoogle ScholarPubMed
Baune, B. T., Wiede, F., Braun, A., Golledge, J., Arolt, V., & Koerner, H. (2008c). Cognitive dysfunction in mice deficient for TNF- and its receptors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(7): 10561064.CrossRefGoogle ScholarPubMed
Beblo, T., Sinnamon, G., & Baune, B. T. (2011). Specifying the neuropsychology of affective disorders: Clinical, demographic and neurobiological factors. Neuropsychology Review, 21(4): 337359.CrossRefGoogle ScholarPubMed
Beck, R. D. Jr., King, M. A., Ha, G. K., Cushman, J. D., Huang, Z., & Petitto, J. M. (2005a). IL-2 deficiency results in altered septal and hippocampal cytoarchitecture: Relation to development and neurotrophins. Journal of Neuroimmunology, 160(1–2): 146153.CrossRefGoogle ScholarPubMed
Beck, R. D. Jr., King, M. A., Huang, Z., & Petitto, J. M. (2002). Alterations in septohippocampal cholinergic neurons resulting from interleukin-2 gene knockout. Brain Research, 955(1–2): 1623.CrossRefGoogle ScholarPubMed
Beck, R. D. Jr., Wasserfall, C., Ha, G. K., Cushman, J. D., Huang, Z., & Petitto, J. M. (2005b). Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice. Brain Research, 1041(2): 223230.CrossRefGoogle ScholarPubMed
Bitsch, A., Kuhlmann, T., Da Costa, C., Bunkowski, S., Polak, T., & Bruck, W. (2000). Tumour necrosis factor alpha mRNA expression in early multiple sclerosis lesions: Correlation with demyelinating activity and oligodendrocyte pathology. Glia, 29(4): 366375.3.0.CO;2-Y>CrossRefGoogle ScholarPubMed
Blaney, P. H. (1986). Affect and memory: A review. Psychological Bulletin, 99(2): 229246.CrossRefGoogle ScholarPubMed
Blatteis, C. M. (1990). Neuromodulative actions of cytokines. Yale Journal of Biology and Medicine, 63(2): 133146.Google ScholarPubMed
Brebner, K., Hayley, S., Zacharko, R., Merali, Z., & Anisman, H. (2000). Synergistic effects of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha: Central monoamine, corticosterone, and behavioral variations. Neuropsychopharmacology, 22(6): 566580.CrossRefGoogle ScholarPubMed
Canli, T., Cooney, R. E., Goldin, P., Shah, M., Sivers, H., Thomason, M. E., … Gotlib, I. H. (2005). Amygdala reactivity to emotional faces predicts improvement in major depression. Neuroreport, 16(12): 12671270.CrossRefGoogle ScholarPubMed
Capuron, L. & Dantzer, R. (2003). Cytokines and depression: The need for a new paradigm. Brain, Behavior, and Immunity, 17(Suppl. 1): S119S124.CrossRefGoogle ScholarPubMed
Chen, C. H., Suckling, J., Ooi, C., Fu, C. H., Williams, S. C., Walsh, N. D., … Bullmore, E. (2008). Functional coupling of the amygdala in depressed patients treated with antidepressant medication. Neuropsychopharmacology, 33(8): 19091918.CrossRefGoogle ScholarPubMed
Cheng, X., Yang, L., He, P., Li, R., & Shen, Y. (2010). Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer’s disease and non-demented patients. Journal of Alzheimer’s Disease, 19(2): 621630.CrossRefGoogle ScholarPubMed
Churchill, L., Taishi, P., Wang, M., Brandt, J., Cearley, C., Rehman, A., & Krueger, J. M. (2006). Brain distribution of cytokine mRNA induced by systemic administration of interleukin-1beta or tumor necrosis factor alpha. Brain Research, 1120(1): 6473.CrossRefGoogle ScholarPubMed
Connor, T. J., Song, C., Leonard, B. E., Merali, Z., & Anisman, H. (1998). An assessment of the effects of central interleukin-1beta, -2, -6, and tumor necrosis factor-alpha administration on some behavioural, neurochemical, endocrine and immune parameters in the rat. Neuroscience, 84(3): 923933.CrossRefGoogle ScholarPubMed
Cronholm, B. & Ottosson, J. O. (1961). Memory functions in endogenous depression before and after electroconvulsive therapy. Archives of General Psychiatry, 5(2): 193199.CrossRefGoogle ScholarPubMed
Danion, J. M., Willard-Schroeder, D., Zimmermann, M. A., Grange, D., Schlienger, J. L., & Singer, L. (1991). Explicit memory and repetition priming in depression: Preliminary findings. Archives of General Psychiatry, 48(8): 707711.CrossRefGoogle ScholarPubMed
Dannlowski, U., Ohrmann, P., Konrad, C., Domschke, K., Bauer, J., Kugel, H., … Suslow, T. (2009). Reduced amygdala-prefrontal coupling in major depression: association with MAOA genotype and illness severity. International Journal of Neuropsychopharmacology, 12(1): 1122.CrossRefGoogle ScholarPubMed
Dantzer, R., O’Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008). From inflammation to sickness and depression: When the immune system subjugates the brain. Nature Reviews Neuroscience, 9: 4656.CrossRefGoogle ScholarPubMed
Davis, M. & Whalen, P. J. (2001). The amygdala: Vigilance and emotion. Molecular Psychiatry, 6(1): 1334.CrossRefGoogle ScholarPubMed
Derubeis, R. J., Siegle, G. J., & Hollon, S. D. (2008). Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms. Nature Reviews Neuroscience, 9: 788796.CrossRefGoogle ScholarPubMed
Dik, M. G., Jonker, C., Hack, C. E., Smit, J. H., Comijs, H. C., & Eikelenboom, P. (2005). Serum inflammatory proteins and cognitive decline in older persons. Neurology, 64(8): 13711377.CrossRefGoogle ScholarPubMed
Dougherty, D. & Rauch, S. (eds.) (2001 ). Psychiatric Neuroimaging Research: Contemporary Strategies. Washington, DC: American Psychiatric Press.Google Scholar
Dunn, A. J. (2006). Effects of cytokines and infections on brain neurochemistry. Clinical Neuroscience Research, 6(1–2): 5268.CrossRefGoogle ScholarPubMed
Dupont, R. M., Jernigan, T. L., Heindel, W., Butters, N., Shafer, K., Wilson, T., … Gillin, J. C. (1995). Magnetic resonance imaging and mood disorders: Localization of white matter and other subcortical abnormalities. Archives of General Psychiatry, 52(9): 747755.CrossRefGoogle ScholarPubMed
Ericsson, A., Kovacs, K. J., & Sawchenko, P. E. (1994). A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons. Journal of Neuroscience, 14(2): 897913.CrossRefGoogle ScholarPubMed
Etkin, A., Gyurak, A., & O’Hara, R. (2013). A neurobiological approach to the cognitive deficits of psychiatric disorders. Dialogues in Clinical Neuroscience, 15(4): 419429.CrossRefGoogle Scholar
Eyre, H. & Baune, B. T. (2012). Neuroplastic changes in depression: A role for the immune system. Psychoneuroendocrinology, 37(9): 13971416.CrossRefGoogle ScholarPubMed
Eyre, H. A., Stuart, M. & Baune, B. T. (2014). A phase-specific neuroimmune model of depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 54: 265274.CrossRefGoogle Scholar
Fischer, R., Maier, O., Siegemund, M., Wajant, H., Scheurich, P., & Pfizenmaier, K. (2011). A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death. PLoS One, 6: e27621.CrossRefGoogle ScholarPubMed
Fossati, P., Amar, G., Raoux, N., Ergis, A. M., & Allilaire, J. F. (1999). Executive functioning and verbal memory in young patients with unipolar depression and schizophrenia. Psychiatry Research, 89(3): 171187.CrossRefGoogle Scholar
Fossati, P., Guillaume, le B., Ergis, A. M., & Allilaire, J. F. (2003). Qualitative analysis of verbal fluency in depression. Psychiatry Research, 117(1): 1724.CrossRefGoogle ScholarPubMed
Gallagher, P. J., Castro, V., Fava, M., Weilburg, J. B., Murphy, S. N., Gainer, V. S., … Perlis, R. H. (2012). Antidepressant response in patients with major depression exposed to NSAIDs: A pharmacovigilance study. American Journal of Psychiatry, 169(10): 10651072.CrossRefGoogle ScholarPubMed
Ghashghaei, H. T. & Barbas, H. (2002). Pathways for emotion: Interactions of prefrontal and anterior temporal pathways in the amygdala of the rhesus monkey. Neuroscience, 115(4): 12611279.CrossRefGoogle ScholarPubMed
Godard, J., Baruch, P., Grondin, S., & Lafleur, M. F. (2012). Psychosocial and neurocognitive functioning in unipolar and bipolar depression: A 12-month prospective study. Psychiatry Research, 196(1): 145153.CrossRefGoogle ScholarPubMed
Gold, S. M. & Irwin, M. R. (2006). Depression and immunity: Inflammation and depressive symptoms in multiple sclerosis. Neurologic Clinics, 24(3): 507519.CrossRefGoogle ScholarPubMed
Golinkoff, M. & Sweeney, J. A. (1989). Cognitive impairments in depression. Journal of Affective Disorders, 17(2): 105112.CrossRefGoogle ScholarPubMed
Grathwohl, S. A., Kalin, R. E., Bolmont, T., Prokop, S., Winkelmann, G., Kaeser, S. A., … Jucker, M. (2009). Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia. Nature Neuroscience, 12: 13611363.CrossRefGoogle ScholarPubMed
Gruzelier, J., Seymour, K., Wilson, L., Jolley, A., & Hirsch, S. (1988). Impairments on neuropsychologic tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Archives of General Psychiatry, 45(7): 623629.CrossRefGoogle ScholarPubMed
Haroon, E., Raison, C. L., & Miller, A. H. (2012). Psychoneuroimmunology meets neuropsychopharmacology: Translational implications of the impact of inflammation on behavior. Neuropsychopharmacology, 37(1): 137162.CrossRefGoogle Scholar
Harrison, N. A., Brydon, L., Walker, C., Gray, M. A., Steptoe, A., & Critchley, H. D. (2009). Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biological Psychiatry, 66(5): 407414.CrossRefGoogle ScholarPubMed
He, P., Zhong, Z., Lindholm, K., Berning, L., Lee, W., Lemere, C., … Shen, Y. (2007a). Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer’s mice. Journal of Cell Biology, 178(5): 829841.CrossRefGoogle ScholarPubMed
He, T., Zong, S., Wu, X., Wei, Y., & Xiang, J. (2007b). CD4+ T cell acquisition of the bystander pMHC I colocalizing in the same immunological synapse comprising pMHC II and costimulatory CD40, CD54, CD80, OX40L, and 41BBL. Biochemical and Biophysical Research Communications, 362(4): 822828.CrossRefGoogle ScholarPubMed
Hein, A. M. & O’Banion, M. K. (2012). Neuroinflammation and cognitive dysfunction in chronic disease and aging. Journal of Neuroimmune Pharmacology, 7(1): 36.CrossRefGoogle Scholar
Herzallah, M. M., Moustafa, A. A., Natsheh, J. Y., Abdellatif, S. M., Taha, M. B., Tayem, Y. I., … Gluck, M. A. (2013). Learning from negative feedback in patients with major depressive disorder is attenuated by SSRI antidepressants. Frontiers in Integrative Neuroscience, 7: 67.CrossRefGoogle ScholarPubMed
Hickie, I. & Lloyd, A. (1995). Are cytokines associated with neuropsychiatric syndromes in humans? International Journal of Immunopharmacology, 17(8): 677683.CrossRefGoogle ScholarPubMed
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008). Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer’s disease mice. Journal of Neuroscience, 28(33): 83548360.CrossRefGoogle ScholarPubMed
Hurlock, E. C. T. (2001). Interferons: Potential roles in affect. Medical Hypotheses, 56(5): 558566.Google ScholarPubMed
Ilsley, J. E., Moffoot, A. P., & O’Carroll, R. E. (1995). An analysis of memory dysfunction in major depression. Journal of Affective Disorders, 35(1–2): 19.CrossRefGoogle ScholarPubMed
Irwin, M. R. & Miller, A. H. (2007). Depressive disorders and immunity: 20 years of progress and discovery. Brain Behavior, and Immunity, 21(4): 374383.CrossRefGoogle ScholarPubMed
Jaeger, J., Berns, S., Uzelac, S., & Davis-Conway, S. (2006). Neurocognitive deficits and disability in major depressive disorder. Psychiatry Research, 145(1): 3948.CrossRefGoogle ScholarPubMed
Jankowsky, J. L. & Patterson, P. H. (1999). Cytokine and growth factor involvement in long-term potentiation. Molecular and Cellular Neuroscience, 14(4–5): 273286.CrossRefGoogle ScholarPubMed
John, G. R., Lee, S. C., & Brosnan, C. F. (2003). Cytokines: Powerful regulators of glial cell activation. Neuroscientist, 9(1): 1022.CrossRefGoogle ScholarPubMed
Jung, J. E., Kim, G. S., & Chan, P. H. (2011). Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke. Stroke, 42(12): 35743579.CrossRefGoogle ScholarPubMed
Kaur, G. & Salm, A. K. (2008). Blunted amygdalar anti-inflammatory cytokine effector response to postnatal stress in prenatally stressed rats. Brain Research, 1196: 112.CrossRefGoogle ScholarPubMed
Kendler, K. S., Thornton, L. M., & Gardner, C. O. (2001). Genetic risk, number of previous depressive episodes, and stressful life events in predicting onset of major depression. American Journal of Psychiatry, 158(4): 582586.CrossRefGoogle ScholarPubMed
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62(6): 593602.CrossRefGoogle ScholarPubMed
Killgore, W. D. & Yurgelun-Todd, D. A. (2004). Activation of the amygdala and anterior cingulate during nonconscious processing of sad versus happy faces. NeuroImage, 21(4): 12151223.CrossRefGoogle ScholarPubMed
Kiosses, D. N. & Alexopoulos, G. S. (2005). IADL functions, cognitive deficits, and severity of depression: A preliminary study. American Journal of Geriatric Psychiatry, 13(3): 244249.CrossRefGoogle ScholarPubMed
Koyama, A., O’Brien, J., Weuve, J., Blacker, D., Metti, A. L., & Yaffe, K. (2013). The role of peripheral inflammatory markers in dementia and Alzheimer’s disease: A meta-analysis. Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 68(4): 433440.CrossRefGoogle ScholarPubMed
Kronfol, Z. & Remick, D. G. (2000). Cytokines and the brain: Implications for clinical psychiatry. American Journal of Psychiatry, 157(5): 683694.CrossRefGoogle ScholarPubMed
Lee, H. J., Choi, J. S., Brown, T. H., & Kim, J. J. (2001). Amygdalar NMDA receptors are critical for the expression of multiple conditioned fear responses. Journal of Neuroscience, 21(11): 41164124.CrossRefGoogle ScholarPubMed
Leonard, B. & Maes, M. (2012). Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression. Neuroscience and Biobehavioral Reviews, 36(2): 764785.CrossRefGoogle ScholarPubMed
Lin, C. H., Yeh, S. H., Lin, C. H., Lu, K. T., Leu, T. H., Chang, W. C., & Gean, P. W. (2001). A role for the PI-3 kinase signaling pathway in fear conditioning and synaptic plasticity in the amygdala. Neuron, 31(5): 841851.CrossRefGoogle ScholarPubMed
Liu, Y. H., Zeng, F., Wang, Y. R., Zhou, H. D., Giunta, B., Tan, J., & Wang, Y. J. (2013). Immunity and Alzheimer’s disease: Immunological perspectives on the development of novel therapies. Drug Discovery Today, 18(23–24): 12121220.CrossRefGoogle ScholarPubMed
London, A., Cohen, M., & Schwartz, M. (2013). Microglia and monocyte-derived macrophages: Functionally distinct populations that act in concert in CNS plasticity and repair. Frontiers in Cellular Neuroscience, 7: 34.CrossRefGoogle ScholarPubMed
Maes, M., Mihaylova, I., Kubera, M., & Ringel, K. (2012a). Activation of cell-mediated immunity in depression: Association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 36(1): 169175.CrossRefGoogle ScholarPubMed
Maes, M., Ringel, K., Kubera, M., Berk, M., & Rybakowski, J. (2012b). Increased autoimmune activity against 5-HT: A key component of depression that is associated with inflammation and activation of cell-mediated immunity, and with severity and staging of depression. Journal of Affective Disorders, 136(3): 386392.CrossRefGoogle ScholarPubMed
Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014). Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neuroscience and Biobehavioral Reviews, 38: 173192.CrossRefGoogle ScholarPubMed
Martinez-Aran, A., Scott, J., Colom, F., Torrent, C., Tabares-Seisdedos, R., Daban, C., … Vieta, E. (2009). Treatment nonadherence and neurocognitive impairment in bipolar disorder. Journal of Clinical Psychiatry, 70(7): 10171023.CrossRefGoogle ScholarPubMed
Mayberg, H. S., Brannan, S. K., Mahurin, R. K., Jerabek, P. A., Brickman, J. S., Tekell, J. L., … Fox, P. T. (1997). Cingulate function in depression: A potential predictor of treatment response. Neuroreport, 8(4): 10571061.CrossRefGoogle ScholarPubMed
McAfoose, J. & Baune, B. T. (2009). Evidence for a cytokine model of cognitive function. Neuroscience and Biobehavioral Reviews, 33(3): 355366.CrossRefGoogle ScholarPubMed
McCabe, C. & Mishor, Z. (2011). Antidepressant medications reduce subcortical-cortical resting-state functional connectivity in healthy volunteers. NeuroImage, 57(4): 13171323.CrossRefGoogle ScholarPubMed
McIlroy, S. P., Vahidassr, M. D., Savage, D. A., Lloyd, F., Patterson, C. C., Lawson, J. T., & Passmore, A. P. (2000). Association of serum AACT levels and AACT signal polymorphism with late-onset Alzheimer’s disease in Northern Ireland. International Journal of Geriatric Psychiatry, 15(3): 260266.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Mcmillian, M., Kong, L. Y., Sawin, S. M., Wilson, B., Das, K., Hudson, P., … Bing, G. (1995). Selective killing of cholinergic neurons by microglial activation in basal forebrain mixed neuronal/glial cultures. Biochemical and Biophysical Research Communications, 215(2): 572577.CrossRefGoogle ScholarPubMed
Mildner, A., Schlevogt, B., Kierdorf, K., Bottcher, C., Erny, D., Kummer, M. P., … Prinz, M. (2011). Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer’s disease. Journal of Neuroscience, 31(31): 1115911171.CrossRefGoogle ScholarPubMed
Miller, A. H., Maletic, V., & Raison, C. L. (2009). Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression. Biological Psychiatry, 65(9): 732741.CrossRefGoogle ScholarPubMed
Morris, G. P., Clark, I. A., Zinn, R., & Vissel, B. (2013). Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research. Neurobiology of Learning and Memory, 105: 4053.CrossRefGoogle ScholarPubMed
Moylan, S., Berk, M., Dean, O. M., Samuni, Y., Williams, L. J., O’Neil, A., … Maes, M. (2014). Oxidative & nitrosative stress in depression: Why so much stress? Neuroscience and Biobehavioral Reviews, 45: 4662.CrossRefGoogle ScholarPubMed
Moylan, S., Maes, M., Wray, N. R., & Berk, M. (2013). The neuroprogressive nature of major depressive disorder: Pathways to disease evolution and resistance, and therapeutic implications. Molecular Psychiatry, 18: 595606.CrossRefGoogle ScholarPubMed
Müller, N., Myint, A. M., & Schwarz, M. J. (2011). Inflammatory biomarkers and depression. Neurotoxicity Research, 19(2): 308318.CrossRefGoogle ScholarPubMed
Müller, N., Schwarz, M. J., Dehning, S., Douhe, A., Cerovecki, A., Goldstein-Muller, B., … Riedel, M. (2006). The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: Results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine. Molecular Psychiatry, 11(7): 680684.CrossRefGoogle ScholarPubMed
Murray, E. A. (2007). The amygdala, reward and emotion. Trends in Cognitive Sciences, 11(11): 489497.CrossRefGoogle ScholarPubMed
Nadjar, A., Bluthe, R. M., May, M. J., Dantzer, R., & Parnet, P. (2005). Inactivation of the cerebral NFkappaB pathway inhibits interleukin-1beta-induced sickness behavior and c-Fos expression in various brain nuclei. Neuropsychopharmacology, 30(8): 14921499.CrossRefGoogle ScholarPubMed
Nilsson, L. N., Arendash, G. W., Leighty, R. E., Costa, D. A., Low, M. A., Garcia, M. F., … Potter, H. (2004). Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation. Neurobiology of Aging, 25(9): 11531167.CrossRefGoogle ScholarPubMed
Pare, D., Quirk, G. J., & Ledoux, J. E. (2004). New vistas on amygdala networks in conditioned fear. Journal of Neurophysiology, 92(1): 19.CrossRefGoogle ScholarPubMed
Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., … Weinberger, D. R. (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience, 8(6): 828834.CrossRefGoogle ScholarPubMed
Phelps, E. A. & Ledoux, J. E. (2005). Contributions of the amygdala to emotion processing: From animal models to human behavior. Neuron, 48(2): 175187.CrossRefGoogle ScholarPubMed
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003a). Neurobiology of emotion perception I: Implications for major psychiatric disorders. Biological Psychiatry, 54(5): 504514.CrossRefGoogle ScholarPubMed
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003b). Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biological Psychiatry, 54(5): 515528.CrossRefGoogle ScholarPubMed
Pickering, M. & O’Connor, J. J. (2007). Pro-inflammatory cytokines and their effects in the dentate gyrus. Progress in Brain Research, 163: 339354.CrossRefGoogle ScholarPubMed
Pizzagalli, D., Pascual-Marqui, R. D., Nitschke, J. B., Oakes, T. R., Larson, C. L., Abercrombie, H. C., … Davidson, R. J. (2001). Anterior cingulate activity as a predictor of degree of treatment response in major depression: Evidence from brain electrical tomography analysis. American Journal of Psychiatry, 158(3): 405415.CrossRefGoogle ScholarPubMed
Porter, R. J., Gallagher, P., Thompson, J. M., & Young, A. H. (2003). Neurocognitive impairment in drug-free patients with major depressive disorder. British Journal of Psychiatry, 182: 214220.CrossRefGoogle ScholarPubMed
Radwanska, K., Nikolaev, E., Knapska, E., & Kaczmarek, L. (2002). Differential response of two subdivisions of lateral amygdala to aversive conditioning as revealed by c-Fos and P-ERK mapping. Neuroreport, 13(17): 22412246.CrossRefGoogle ScholarPubMed
Raison, C. L., Capuron, L., & Miller, A. H. (2006). Cytokines sing the blues: Inflammation and the pathogenesis of depression. Trends in Immunology, 27(1): 2431.CrossRefGoogle ScholarPubMed
Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., … Miller, A. H. (2013). A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: The role of baseline inflammatory biomarkers. Archives of General Psychiatry, 70(1): 3141.Google ScholarPubMed
Ramos, A. & Mormede, P. (1998). Stress and emotionality: A multidimensional and genetic approach. Neuroscience and Biobehavioral Reviews, 22(1): 3357.CrossRefGoogle ScholarPubMed
Ransohoff, R. M. & Benveniste, E. N. (eds.) (2006). Cytokines and the CNS. New York: Taylor & Francis.Google Scholar
Ravnkilde, B., Videbech, P., Clemmensen, K., Egander, A., Rasmussen, N. A., & Rosenberg, R. (2002). Cognitive deficits in major depression. Scandinavian Journal of Psychology, 43(3): 239251.CrossRefGoogle ScholarPubMed
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmacher, T. (2001). Cytokine-associated emotional and cognitive disturbances in humans. Archives of General Psychiatry, 58(5): 445452.CrossRefGoogle ScholarPubMed
Rose, E. J. & Ebmeier, K. P. (2006). Pattern of impaired working memory during major depression. Journal of Affective Disorders, 90(2–3): 149161.CrossRefGoogle ScholarPubMed
Rothwell, N. J. & Loddick, S. (eds.) (2002). Immune and Inflammatory Responses in the Nervous System. New York: Oxford University Press.CrossRefGoogle Scholar
Saha, R. N., Liu, X., & Pahan, K. (2006). Up-regulation of BDNF in astrocytes by TNF-alpha: A case for the neuroprotective role of cytokine. Journal of Neuroimmune Pharmacology, 1(3): 212222.CrossRefGoogle ScholarPubMed
Sakumoto, R., Kasuya, E., Komatsu, T., & Akita, T. (2003). Central and peripheral concentrations of tumor necrosis factor-alpha in Chinese Meishan pigs stimulated with lipopolysaccharide. Journal of Animal Science, 81(5): 12741280.CrossRefGoogle ScholarPubMed
Santello, M. & Volterra, A. (2012). TNF-alpha in synaptic function: Switching gears. Trends in Neuroscience, 35(10): 638647.CrossRefGoogle ScholarPubMed
Schwartz, M., Sivron, T., Eitan, S., Hirschberg, D. L., Lotan, M., & Elman-Faber, A. (1994). Cytokines and cytokine-related substances regulating glial cell response to injury of the central nervous system. Progress in Brain Research, 103: 331341.CrossRefGoogle ScholarPubMed
Schwartz, M., Solomon, A., Lavie, V., Ben-Bassat, S., Belkin, M., & Cohen, A. (1991). Tumor necrosis factor facilitates regeneration of injured central nervous system axons. Brain Research, 545(1–2): 334338.CrossRefGoogle ScholarPubMed
Sei, Y., Vitkovic, L., & Yokoyama, M. M. (1995). Cytokines in the central nervous system: Regulatory roles in neuronal function, cell death and repair. Neuroimmunomodulation, 2(3): 121133.CrossRefGoogle ScholarPubMed
Sheline, Y. I., Gado, M. H., & Kraemer, H. C. (2003). Untreated depression and hippocampal volume loss. American Journal of Psychiatry, 160(8): 15161518.CrossRefGoogle ScholarPubMed
Siegle, G. J., Carter, C. S., & Thase, M. E. (2006). Use of fMRI to predict recovery from unipolar depression with cognitive behavior therapy. American Journal of Psychiatry, 163(4): 735738.CrossRefGoogle ScholarPubMed
Sierra, A., Abiega, O., Shahraz, A., & Neumann, H. (2013). Janus-faced microglia: Beneficial and detrimental consequences of microglial phagocytosis. Frontiers in Cellular Neuroscience, 7: 6.CrossRefGoogle ScholarPubMed
Slavich, G. M. & Irwin, M. R. (2014). From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. Psychological Bulletin, 140(3): 774815.CrossRefGoogle ScholarPubMed
Stefanacci, L. & Amaral, D. G. (2000). Topographic organization of cortical inputs to the lateral nucleus of the macaque monkey amygdala: A retrograde tracing study. Journal of Comparative Neurology, 421(1): 5279.3.0.CO;2-O>CrossRefGoogle Scholar
Streit, W. J., Braak, H., Xue, Q. S., & Bechmann, I. (2009). Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease. Acta Neuropathologica, 118(4): 475485.CrossRefGoogle ScholarPubMed
Streit, W. J. & Xue, Q. S. (2012). Alzheimer’s disease, neuroprotection, and CNS immunosenescence. Frontiers in Pharmacology, 3: 138.CrossRefGoogle ScholarPubMed
Swardfager, W., Lanctot, K., Rothenburg, L., Wong, A., Cappell, J., & Herrmann, N. (2010). A meta-analysis of cytokines in Alzheimer’s disease. Biological Psychiatry, 68(10): 930941.CrossRefGoogle ScholarPubMed
Tobinick, E. (2007). Perispinal etanercept for treatment of Alzheimer’s disease. Current Alzheimer Research, 4: 550552.CrossRefGoogle ScholarPubMed
Tweedie, D., Sambamurti, K., & Greig, N. H. (2007). TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: New drug candidates and targets. Current Alzheimer Research, 4: 378385.CrossRefGoogle ScholarPubMed
Veiel, H. O. (1997). A preliminary profile of neuropsychological deficits associated with major depression. Journal of Clinical and Experimental Psychology, 19(4): 587603.Google ScholarPubMed
Videbech, P. & Ravnkilde, B. (2004). Hippocampal volume and depression: A meta-analysis of MRI studies. American Journal of Psychiatry, 161(11): 19571966.CrossRefGoogle ScholarPubMed
Vitkovic, L., Bockaert, J., & Jacque, C. (2000a). “Inflammatory” cytokines: Neuromodulators in normal brain? Journal of Neurochemistry, 74(2): 457471.CrossRefGoogle ScholarPubMed
Vitkovic, L., Konsman, J. P., Bockaert, J., Dantzer, R., Homburger, V., & Jacque, C. (2000b). Cytokine signals propagate through the brain. Molecular Psychiatry, 5(6): 604615.CrossRefGoogle ScholarPubMed
Viviani, B., Gardoni, F., & Marinovich, M. (2007). Cytokines and neuronal ion channels in health and disease. International Review of Neurobiology, 82: 247263.CrossRefGoogle ScholarPubMed
Warner-Schmidt, J. L., Vanover, K. E., Chen, E. Y., Marshall, J. J., & Greengard, P. (2011). Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proceedings of the National Academy of Sciences of the United States of America, 108(22): 92629267.CrossRefGoogle ScholarPubMed
Wei, H., Zou, H., Sheikh, A. M., Malik, M., Dobkin, C., Brown, W. T., & Li, X. (2011). IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation. Journal of Neuroinflammation, 8: 52.CrossRefGoogle ScholarPubMed
Weiskrantz, L. (1956). Behavioral changes associated with ablation of the amygdaloid complex in monkeys. Journal of Comparative and Physiological Psychology, 49(4): 381391.CrossRefGoogle ScholarPubMed
Westheide, J., Quednow, B. B., Kuhn, K. U., Hoppe, C., Cooper-Mahkorn, D., Hawellek, B., … Wagner, M. (2008). Executive performance of depressed suicide attempters: The role of suicidal ideation. European Archives of Psychiatry and Clinical Neuroscience, 258(7): 414421.CrossRefGoogle ScholarPubMed
Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002). Cytokines and cognition: The case for a head-to-toe inflammatory paradigm. Journal of the American Geriatrics Society, 50(12): 20412056.CrossRefGoogle ScholarPubMed
Yirmiya, R. & Goshen, I. (2011). Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain, Behavior, and Immunity, 25(2): 181213.CrossRefGoogle ScholarPubMed

References

Anacker, C., Zunszain, P. A., Cattaneo, A., Carvalho, L. A., Garabedian, M. J., Thuret, S., … Pariante, C. M. (2011). Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Molecular Psychiatry, 16: 738750.CrossRefGoogle ScholarPubMed
Anaya, C., Martinez Aran, A., Ayuso-Mateos, J. L., Wykes, T., Vieta, E., & Scott, J. (2012). A systematic review of cognitive remediation for schizo-affective and affective disorders. Journal of Affective Disorders, 142: 1321.CrossRefGoogle ScholarPubMed
Anisman, H., Ravindran, A. V., Griffiths, J., & Merali, Z. (1999). Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features. Molecular Psychiatry, 4: 182188.CrossRefGoogle ScholarPubMed
Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., … Muller-Myhsok, B. (2004). Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nature Genetics, 36: 13191325.CrossRefGoogle ScholarPubMed
Bond, D. & Young, A. (2007). The hypothalamic–pituitary–adrenal axis in bipolar disorder. In Soares, J. C. & Young, A. H. (eds.), Bipolar Disorder: Basic Mechanisms and Therapeutic Implications, 2nd edn. (pp. 145160). New York: Taylor & Francis.CrossRefGoogle Scholar
Brunner, R., Schaefer, D., Hess, K., Parzer, P., Resch, F., & Schwab, S. (2005). Effect of corticosteroids on short-term and long-term memory. Neurology, 64(2): 335337.CrossRefGoogle ScholarPubMed
Buchanan, T. W. & Lovallo, W. R. (2001). Enhanced memory for emotional material following stress-level cortisol treatment in humans. Psychoneuroendocrinology, 26(3): 307317.CrossRefGoogle ScholarPubMed
Carroll, B. J., Cassidy, F., Naftolowitz, D., Tatham, N. E., Wilson, W. H., Iranmanesh, A., … Veldhuis, J. D. (2007). Pathophysiology of hypercortisolism in depression. Acta Psychiatrica Scandinavica Supplementum, 433: 90103.CrossRefGoogle Scholar
Cattaneo, A., Gennarelli, M., Uher, R., Breen, G., Farmer, A., Aitchison, K. J., … Paiante, C. M. (2013). Candidate genes expression profile associated with antidepressants response in the GENDEP Study: Differentiating between baseline “predictors” and longitudinal “targets.” Neuropsychopharmacology, 38(3): 377385.CrossRefGoogle ScholarPubMed
Cleare, A. J. & Wessely, S. C. (1996). Chronic fatigue syndrome: A stress disorder? Hospital Medicine, 55(9): 571574.Google ScholarPubMed
Cole, J., Toga, A. W., Hojatkashani, C., Thompson, P., Costafreda, S. G., Cleare, A. J., … Fu, C. H. Y. (2010). Subregional hippocampal deformations in major depressive disorder. Journal of Affective Disorders, 126(1–2): 272277.CrossRefGoogle ScholarPubMed
Coluccia, D., Wolf, O. T., Kollias, S., Roozendaal, B., Forster, A., & De Quervain, D. J.-F. (2008). Glucocorticoid therapy-induced memory deficits: Acute versus chronic effects. Journal of Neuroscience, 28(13): 34743478.CrossRefGoogle ScholarPubMed
Daban, C., Vieta, E., Mackin, P., & Young, A. H. (2005). Hypothalamic–pituitary–adrenal axis and bipolar disorder. Psychiatric Clinics of North America, 28(2): 469480.CrossRefGoogle ScholarPubMed
Feldman, S., Conforti, N., & Weidenfeld, J. (1995). Limbic pathways and hypothalamic neurotransmitters mediating adrenocortical responses to neural stimuli. Neuroscience and Biobehavioral Reviews, 19(2): 235240.CrossRefGoogle ScholarPubMed
Finsterwald, C. & Alberini, C. M. (2014). Stress and glucocorticoid receptor-dependent mechanisms in long-term memory: From adaptive responses to psychopathologies. Neurobiology of Learning and Memory, 112: 1729.CrossRefGoogle ScholarPubMed
Gallagher, P., Malik, N., Newham, J., Young, A. H., Ferrier, I. N., & Mackin, P. (2008). Antiglucocorticoid treatments for mood disorders. Cochrane Database of Systematic Reviews, 1: CD005168.Google Scholar
Gallagher, P., Watson, S., Smith, M. S., Young, A. H., & Ferrier, I. N. (2007). Plasma cortisol-dehydroepiandrosterone (DHEA) ratios in schizophrenia and bipolar disorder. Schizophrenia Research, 90(1–3): 258265.CrossRefGoogle ScholarPubMed
Hashimoto, K., Shimizu, E., & Iyo, M. (2004). Critical role of brain-derived neurotrophic factor in mood disorders. Brain Research Reviews, 45(2): 104114.CrossRefGoogle ScholarPubMed
Hellemans, K. G. C., Verma, P., Yoon, E., Yu, W. K., Young, A. H., & Weinberg, J. (2010). Prenatal alcohol exposure and chronic mild stress differentially alter depressive- and anxiety-like behaviors in male and female offspring. Alcoholism: Clinical and Experimental Research, 34(4): 633645.CrossRefGoogle ScholarPubMed
Hemmeter, U., Heimberg, D. R., Naber, G., Hobi, V., & Holsboer-Trachsler, E. (2000). Contingent negative variation and Dex-CRH test in patients with major depression. Journal of Psychiatric Research, 34(4–5): 365367.CrossRefGoogle ScholarPubMed
Herane Vives, A., De Angel, V., Papadopoulos, A., Strawbridge, R., Wise, T., Young, A. H., … Cleare, A. (2015). The relationship between cortisol, stress and psychiatric illness: new insights using hair analysis. Journal of Psychiatric Research, 70: 3849. doi: 10.1016/j.jpsychires.2015.08.007.CrossRefGoogle ScholarPubMed
Heuser, I. J., Gotthardt, U., Schweiger, U., Schmider, J., Lammers, C.-H., Dettling, M., & Holsboer, F. (1994). Age-associated changes of pituitary-adrenocortical hormone regulation in humans: Importance of gender. Neurobiology of Aging, 15(2): 227231.CrossRefGoogle ScholarPubMed
Hinkelmann, K., Moritz, S., Botzenhardt, J., Riedesel, K., Wiedemann, K., Kellner, M., & Otte, C. (2009). Cognitive impairment in major depression: Association with salivary cortisol. Biological Psychiatry, 66(9): 879885.CrossRefGoogle ScholarPubMed
Hughes, J. H., Gallagher, P., Stewart, M. E., Matthews, D., Kelly, T.P., & Young, A. H. (2003). The effects of acute tryptophan depletion on neuropsychological function. Journal of Psychopharmacology, 17(3): 300309.CrossRefGoogle ScholarPubMed
Juruena, M. F., Cleare, A. J., Papadopoulos, A. S., Poon, L., Lightman, S., & Pariante, P. M. (2010). The prednisolone suppression test in depression: Dose-response and changes with antidepressant treatment. Psychoneuroendocrinology, 35(10): 14861491.CrossRefGoogle ScholarPubMed
Juruena, M. F., Pariante, C. M., Papadopoulos, A. S., Poon, L., Lightman, S., & Cleare, A. J. (2009). Prednisolone suppression test in depression: Prospective study of the role of HPA axis dysfunction in treatment resistance. British Journal of Psychiatry, 194(4): 342349.CrossRefGoogle ScholarPubMed
Klok, M. D., Giltay, E. J., Van Der Does, A. J., Geleijnse, J. M., Antypa, N., Penninx, B. W. J. H., … DeRijk, R. H. (2011). A common and functional mineralocorticoid receptor haplotype enhances optimism and protects against depression in females. Translational Psychiatry, 1(12): e62.CrossRefGoogle ScholarPubMed
Knorr, U., Vinberg, M., Kessing, L. V., & Wetterslev, J. (2010). Salivary cortisol in depressed patients versus control persons: A systematic review and meta-analysis. Psychoneuroendocrinology, 35(9): 12751286.CrossRefGoogle Scholar
Kuningas, M., De Rijk, R. H., Westendorp, R. G., Jolles, J., Slagboom, P. E., & Van Heemst, D. (2007). Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors. Neuropsychopharmacology, 32(6): 12951301.CrossRefGoogle ScholarPubMed
Liu, Z., Zhu, F., Wang, G., Xiao, Z., Tang, J., Liu, W., … Li, W. (2007). Association study of corticotropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders. Neuroscience Letters, 414(2): 155158.CrossRefGoogle ScholarPubMed
Lupien, S. J., Fiocco, A., Wan, N., Maheu, F., Lord, C., Schramek, T., & Tu, M. T. (2005). Stress hormones and human memory function across the lifespan. Psychoneuroendocrinology, 30(3): 225242.CrossRefGoogle ScholarPubMed
Maripuu, M., Wikgren, M., Karling, P., Adolfsson, R., & Norrback, K.-F. (2014). Relative hypo- and hypercortisolism are both associated with depression and lower quality of life in bipolar disorder: A cross-sectional study. PLoS One, 9: e98682.CrossRefGoogle ScholarPubMed
Markopoulou, K., Papadopoulos, A., Juruena, M. F., Poon, L., Pariante, C. M., & Cleare, A. J. (2009). The ratio of cortisol/DHEA in treatment resistant depression. Psychoneuroendocrinology, 34(1): 1926.CrossRefGoogle ScholarPubMed
McQuade, R. & Young, A. H. (2000). Future therapeutic targets in mood disorders: The glucocorticoid receptor. British Journal of Psychiatry, 177(5): 390395.CrossRefGoogle ScholarPubMed
Musselman, D. L. & Nemeroff, C. B. (1996). Depression and endocrine disorders: Focus on the thyroid and adrenal system. British Journal of Psychiatry Supplement 7, 168(30): 123128.CrossRefGoogle Scholar
Pariante, C. M. (2006). The glucocorticoid receptor: Part of the solution or part of the problem? Journal of Psychopharmacology, 20(4): 7984.CrossRefGoogle ScholarPubMed
Perroud, N., Dayer, A., Piguet, C., Nallet, A., Favre, S., Malafosse, A., & Aubry, J.-M. (2014). Childhood maltreatment and methylation of the glucocorticoid receptor gene NR3C1 in bipolar disorder. British Journal of Psychiatry, 204(1): 3035.CrossRefGoogle ScholarPubMed
Prickaerts, J. & Steckler, T. (2005). Effects of glucocorticoids on emotion and cognitive processes in animals. In: Steckler, T. & Reul, J. (eds.), Techniques in the Behavioral and Neural Sciences (pp. 359385). Amsterdam: Elsevier.Google Scholar
Reus, V. I. & Wolkowitz, O. M. (2001). Antiglucocorticoid drugs in the treatment of depression. Expert Opinion on Investigational Drugs, 10(10): 17891796.CrossRefGoogle ScholarPubMed
Roberts, A. D. L., Charler, M. L., Papadopoulos, A., Wessely, S., Chalder, T., & Cleare, A. J. (2010). Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome? Psychological Medicine, 40(3): 515522.CrossRefGoogle ScholarPubMed
Robinson, L. J., Thompson, J. M., Gallagher, P., Goswami, U., Young, A. H., Ferrier, N., & Moore, P. B. (2006). A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. Journal of Affective Disorders, 93(1–3): 105115.CrossRefGoogle ScholarPubMed
Roozendaal, B. (2000). Glucocorticoids and the regulation of memory consolidation. Psychoneuroendocrinology, 25(3): 213238.CrossRefGoogle ScholarPubMed
Rubinow, D. R., Post, R. M., Savard, R., & Gold, P. W. (1984). Cortisol hypersecretion and cognitive impairment in depression. Archives of General Psychiatry, 41: 279283.CrossRefGoogle ScholarPubMed
Schlosser, N., Wolf, O. T., Fernando, S. C., Terfehr, K., Otte, C., Spitzer, C., & Wingenfeld, K. (2013). Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls. Psychiatry Research, 209(3): 439446.CrossRefGoogle ScholarPubMed
Slattery, M. J., Grieve, A. J., Ames, M. E., Armstrong, J. M., & Essex, M. J. (2013). Neurocognitive function and state cognitive stress appraisal predict cortisol reactivity to an acute psychosocial stressor in adolescents. Psychoneuroendocrinology, 38(8): 13181327.CrossRefGoogle Scholar
Spijker, A. T. & Van Rossum, E. F. (2012). Glucocorticoid sensitivity in mood disorders. Neuroendocrinology, 95(3): 179186.CrossRefGoogle ScholarPubMed
Stanton, B. R., David, A. S., Cleare, A. J., Sierra, M., Lambert, M. V., Phillips, M. L., … Young, A. H. (2001). Basal activity of the hypothalamic–pituitary–adrenal axis in patients with depersonalization disorder. Psychiatry Research, 104(1): 8589.CrossRefGoogle ScholarPubMed
Starkman, M. N. & Schteingart, D. E. (1981). Neuropsychiatric manifestations of patients with Cushing’s syndrome: Relationship to cortisol and adrenocorticotropic hormone levels. Archives of Internal Medicine, 141(2): 215219.CrossRefGoogle ScholarPubMed
Strawbridge, R., Arnone, D., Danese, A., Papadopoulos, A., Herane Vives, A., & Cleare, A. J. (2015). Inflammation and clinical response to treatment in depression: A meta-analysis. European Neuropsychopharmacology, 25(10): 153243. doi: 10.1016/j.euroneuro.2015.06.007.CrossRefGoogle ScholarPubMed
Szczepankiewicz, A., Leszczyńska-Rodziewicz, A., Pawlak, J., Rajewska-Rager, A., Dmitrzak-Weglarz, M., Wilkosc, M., … Hauser, J. (2011). Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder. Journal of Affective Disorders, 134(1–3): 138144.CrossRefGoogle ScholarPubMed
Tak, L. M., Cleare, A. J., Ormel, J., Manoharan, A., Kok, I. C., Wessely, S., & Rosmalen, J. G. M. (2011). Meta-analysis and meta-regression of hypothalamic–pituitary–adrenal axis activity in functional somatic disorders. Biological Psychology, 87(2): 183194.CrossRefGoogle ScholarPubMed
Thompson, J. M., Gallagher, P., Hughes, J. H., Watson, S., Gray, J. M., Ferrier, I. N., & Young, A. H. (2005). Neurocognitive impairment in euthymic patients with bipolar affective disorder. British Journal of Psychiatry, 186: 3240.CrossRefGoogle ScholarPubMed
Van Ast, V. A., Cornelisse, S., Meeter, M., & Kindt, M. (2014). Cortisol mediates the effects of stress on the contextual dependency of memories. Psychoneuroendocrinology, 41: 97110.CrossRefGoogle ScholarPubMed
Van Rossum, E. F., Binder, E. B., Majer, M., Koper, J. W., Ising, M., Modell, S., … Holsboer, F. (2006). Polymorphisms of the glucocorticoid receptor gene and major depression. Biological Psychiatry, 59(8): 681688.CrossRefGoogle ScholarPubMed
Watson, S., Gallagher, P., Ferrier, I. N., & Young, A. H. (2006a). Post-dexamethasone arginine vasopressin levels in patients with severe mood disorders. Journal of Psychiatric Research, 40(4): 353359.CrossRefGoogle ScholarPubMed
Watson, S., Gallagher, P., Porter, R. J., Smith, M. S., Herron, L. J., Bulmer, S., … Ferrier, I. N. (2012). A randomized trial to examine the effect of mifepristone on neuropsychological performance and mood in patients with bipolar depression. Biological Psychiatry, 72(11): 943949.CrossRefGoogle ScholarPubMed
Watson, S., Gallagher, P., Ritchie, J. C., Ferrier, I. N., & Young, A. H. (2004). Hypothalamic–pituitary–adrenal axis function in patients with bipolar disorder. British Journal of Psychiatry, 184: 496502.CrossRefGoogle ScholarPubMed
Watson, S., Thompson, J. M., Ritchie, J. C., Ferrier, I. N., & Young, A. H. (2006b). Neuropsychological impairment in bipolar disorder: The relationship with glucocorticoid receptor function. Bipolar Disorders, 8(1): 8590.CrossRefGoogle ScholarPubMed
Webster, M. J., Knable, M. B., O’Grady, J., Orthmann, J., & Weickert, C. S. (2002). Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Molecular Psychiatry, 7(9): 985994, 924.CrossRefGoogle ScholarPubMed
Wolkowitz, O. M., Reus, V. I., Keebler, A., Nelson, N., Friedland, M., Brizendine, L., & Roberts, E. (1999). Double-blind treatment of major depression with dehydroepiandrosterone. American Journal of Psychiatry, 156(4): 646649.CrossRefGoogle ScholarPubMed
Wolkowitz, O. M., Reus, V. I., Weingartner, H., Thompson, K., Breier, A., Doran, A., … Pickar, D. (1990). Cognitive effects of corticosteroids. American Journal of Psychiatry, 147(10): 12971303.Google ScholarPubMed
Wooderson, S. C., Fekadu, A., Markopoulou, K., Rane, L. J., Poon, L., & Juruena, M. F. (2014). Long-term symptomatic and functional outcome following an intensive inpatient multidisciplinary intervention for treatment-resistant affective disorders. Journal of Affective Disorders, 166: 334342.CrossRefGoogle ScholarPubMed
Yehuda, R., Boisoneau, D., Mason, J. W., & Giller, E. L. (1993). Glucocorticoid receptor number and cortisol excretion in mood, anxiety, and psychotic disorders. Biological Psychiatry, 34(1–2): 1825.CrossRefGoogle ScholarPubMed
Young, A. H. (2011). More good news about the magic ion: Lithium may prevent dementia. British Journal of Psychiatry, 198(5): 336337.CrossRefGoogle ScholarPubMed
Young, A. H., Gallagher, P., & Porter, R. J. (2002). Elevation of the cortisol-dehydroepiandrosterone ratio in drug-free depressed patients. American Journal of Psychiatry, 159(7): 12371239.CrossRefGoogle ScholarPubMed
Young, A. H., Gallagher, P., Watson, S., Del-Estal, D., Owen, B. M., & Ferrier, I. N. (2004). Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacology, 29(8): 15381545.CrossRefGoogle ScholarPubMed
Young, A. H., Sahakian, B. J., Robbins, T. W., & Cowen, P. J. (1999). The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers. Psychopharmacology, 145(3): 260266.CrossRefGoogle ScholarPubMed
Zobel, A., Jessen, F., Von Widdern, O., Schuhmacher, A., Höfels, S., Metten., M., … Schwab, S. G. (2008). Unipolar depression and hippocampal volume: Impact of DNA sequence variants of the glucocorticoid receptor gene. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B(6): 836843.CrossRefGoogle ScholarPubMed
Zobel, A. W., Schulze-Rauschenbach, S., Von Widdern, O. C., Metten, M., Freymann, N., Grasmäder, K., … Maier, W. (2004). Improvement of working but not declarative memory is correlated with HPA normalization during antidepressant treatment. Journal of Psychiatric Research, 38(4): 377383.CrossRefGoogle Scholar

References

Abe, O., Yamasue, H., Kasai, K., Yamada, H., Aoki, S., Inoue, H., … Ohtomo, K. (2010). Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depression. Psychiatry Research: Neuroimaging, 181(1): 6470.CrossRefGoogle ScholarPubMed
Aizenstein, H. J., Butters, M. A., Figurski, J. L., Stenger, V. A., Reynolds, C. F. III, & Carter, C. S. (2005). Prefrontal and striatal activation during sequence learning in geriatric depression. Biological Psychiatry, 58(4): 290296.CrossRefGoogle ScholarPubMed
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9(1): 357381.CrossRefGoogle ScholarPubMed
Alexopoulos, G. S. (2003). Role of executive function in late-life depression. Journal of Clinical Psychiatry, 64(Suppl. 14): 1823.Google ScholarPubMed
Alexopoulos, G. S., Meyers, B. S., Young, R. C., Campbell, S., Silbersweig, D., & Charlson, M. (1997). “Vascular depression” hypothesis. Archives of General Psychiatry, 54(10): 915922.CrossRefGoogle ScholarPubMed
Aron, A. R., Behrens, T. E., Smith, S., Frank, M. J., & Poldrack, R. A. (2007). Triangulating a cognitive control network using diffusion-weighted magnetic resonance imaging (MRI) and functional MRI. Journal of Neuroscience, 27(14): 37433752.CrossRefGoogle ScholarPubMed
Aston, C., Jiang, L., & Sokolov, B. P. (2004). Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder. Molecular Psychiatry, 10(3): 309322.CrossRefGoogle Scholar
Baird, B., Smallwood, J., Gorgolewski, K. J., & Margulies, D. S. (2013). Medial and lateral networks in anterior prefrontal cortex support metacognitive ability for memory and perception. Journal of Neuroscience, 33(42): 1665716665.CrossRefGoogle ScholarPubMed
Beasley, C. L., Honavar, M., Everall, I. P., & Cotter, D. (2009). Two-dimensional assessment of cytoarchitecture in the superior temporal white matter in schizophrenia, major depressive disorder and bipolar disorder. Schizophrenia Research, 115(2): 156162.CrossRefGoogle ScholarPubMed
Bora, E., Fornito, A., Pantelis, C., & Yücel, M. (2012a). Gray matter abnormalities in major depressive disorder: A meta-analysis of voxel based morphometry studies. Journal of Affective Disorders, 138(1): 918.CrossRefGoogle ScholarPubMed
Bora, E., Harrison, B. J., Davey, C. G., Yücel, M., & Pantelis, C. (2012b). Meta-analysis of volumetric abnormalities in cortico-striatal-pallidal-thalamic circuits in major depressive disorder. Psychological Medicine, 42(4): 671681.CrossRefGoogle ScholarPubMed
Bracht, T., Federspiel, A., Schnell, S., Horn, H., Höfle, O., Wiest, R., … Walther, S. (2012). Cortico-cortical white matter motor pathway microstructure is related to psychomotor retardation in major depressive disorder. PLoS One, 7(12): e52238.CrossRefGoogle ScholarPubMed
Buyukdura, J. S., McClintock, S. M., & Croarkin, P. E. (2011). Psychomotor retardation in depression: Biological underpinnings, measurement, and treatment. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 35(2): 395409.CrossRefGoogle ScholarPubMed
Caligiuri, M. P. & Ellwanger, J. (2000). Motor and cognitive aspects of motor retardation in depression. Journal of Affective Disorders, 57(1–3): 8393.CrossRefGoogle ScholarPubMed
Chantiluke, K., Halari, R., Simic, M., Pariante, C. M., Papadopoulos, A., Giampietro, V., & Rubia, K. (2012). Fronto-striato-cerebellar dysregulation in adolescents with depression during motivated attention. Biological Psychiatry, 71(1): 5967.CrossRefGoogle ScholarPubMed
Chen, C.-S., Chiang, I., Li, C.-W., Lin, W.-C., Lu, C.-Y., Hsieh, T.-J., … Kuo, Y.-T. (2009). Proton magnetic resonance spectroscopy of late-life major depressive disorder. Psychiatry Research: Neuroimaging, 172(3): 210214.CrossRefGoogle ScholarPubMed
Cooney, R. E., Joormann, J., Eugène, F., Dennis, E. L., & Gotlib, I. H. (2010). Neural correlates of rumination in depression. Cognitive, Affective, & Behavioral Neuroscience, 10(4): 470478.CrossRefGoogle ScholarPubMed
Cotter, D., Mackay, D., Chana, G., Beasley, C., Landau, S., & Everall, I. P. (2002). Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder. Cerebral Cortex, 12(4): 386394.CrossRefGoogle ScholarPubMed
Crowell, A. L., Riva-Posse, P., Garlow, S. J., & Mayberg, H. S. (2014). Toward an understanding of the neural circuitry of major depressive disorder through the clinical response to deep brain stimulation of different anatomical targets. Current Behavioral Neuroscience Reports, 1(2): 5563.CrossRefGoogle Scholar
Dannlowski, U., Ohrmann, P., Konrad, C., Domschke, K., Bauer, J., Kugel, H., … Baune, B. T. (2009). Reduced amygdala–prefrontal coupling in major depression: Association with MAOA genotype and illness severity. International Journal of Neuropsychopharmacology, 12(1): 1122.CrossRefGoogle ScholarPubMed
DeRubeis, R. J., Siegle, G. J., & Hollon, S. D. (2008). Cognitive therapy versus medication for depression: Treatment outcomes and neural mechanisms. Nature Reviews Neuroscience, 9(10): 788796.CrossRefGoogle ScholarPubMed
Disner, S. G., Beevers, C. G., Haigh, E. A. P., & Beck, A. T. (2011). Neural mechanisms of the cognitive model of depression. Nature Reviews Neuroscience, 12(8): 467477.CrossRefGoogle ScholarPubMed
Draganski, B., Kherif, F., Klöppel, S., Cook, P. A., Alexander, D. C., Parker, G. J. M., … Frackowiak, R. S. J. (2008). Evidence for segregated and integrative connectivity patterns in the human basal ganglia. Journal of Neuroscience, 28(28): 71437152.CrossRefGoogle ScholarPubMed
Drevets, W. C., Savitz, J., & Trimble, M. (2008). The subgenual anterior cingulate cortex in mood disorders. CNS Spectrums, 13(8): 663681.CrossRefGoogle ScholarPubMed
Elliott, R., Rubinsztein, J. S., Sahakian, B. J., & Dolan, R. J. (2002). The neural basis of mood-congruent processing biases in depression. Archives of General Psychiatry, 59(7): 597604.CrossRefGoogle ScholarPubMed
Etkin, A., Egner, T., Peraza, D. M., Kandel, E. R., & Hirsch, J. (2006). Resolving emotional conflict: A role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron, 51(6): 871882.CrossRefGoogle ScholarPubMed
Eugène, F., Joormann, J., Cooney, R. E., Atlas, L. Y., & Gotlib, I. H. (2010). Neural correlates of inhibitory deficits in depression. Psychiatry Research: Neuroimaging, 181(1): 3035.CrossRefGoogle ScholarPubMed
Fales, C. L., Barch, D. M., Rundle, M. M., Mintun, M. A., Snyder, A. Z., Cohen, J. D., … Sheline, Y. I. (2008). Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression. Biological Psychiatry,63(4): 377384.CrossRefGoogle ScholarPubMed
Fornage, M., Debette, S., Bis, J. C., Schmidt, H., Ikram, M. A., Dufouil, C., … Launer, L. J. (2011). Genome-wide association studies of cerebral white matter lesion burden. Annals of Neurology, 69(6): 928939.CrossRefGoogle ScholarPubMed
Greicius, M. (2008). Resting-state functional connectivity in neuropsychiatric disorders. Current Opinion in Neurology, 21(4): 424430.CrossRefGoogle ScholarPubMed
Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., … Schatzberg, A. F. (2007). Resting-state functional connectivity in major depression: Abnormally increased contributions from subgenual cingulate cortex and thalamus. Biological Psychiatry, 62(5): 429437.CrossRefGoogle ScholarPubMed
Halari, R., Simic, M., Pariante, C. M., Papadopoulos, A., Cleare, A., Brammer, M., … Rubia, K. (2009). Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naïve adolescents with depression compared to controls. Journal of Child Psychology and Psychiatry, 50(3): 307316.CrossRefGoogle ScholarPubMed
Hamilton, J. P. & Gotlib, I. H. (2008). Neural substrates of increased memory sensitivity for negative stimuli in major depression. Biological Psychiatry, 63(12): 11551162.CrossRefGoogle ScholarPubMed
Heller, A. S., Johnstone, T., Shackman, A. J., Light, S. N., Peterson, M. J., Kolden, G. G., … Davidson, R. J. (2009). Reduced capacity to sustain positive emotion in major depression reflects diminished maintenance of fronto-striatal brain activation. Proceedings of the National Academy of Sciences of the United States of America, 106(52): 2244522450.CrossRefGoogle ScholarPubMed
Johansen-Berg, H., Gutman, D. A., Behrens, T. E. J., Matthews, P. M., Rushworth, M. F. S., Katz, E., … Mayberg, H. S. (2008). Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression. Cerebral Cortex, 18(6): 13741383.CrossRefGoogle ScholarPubMed
Johnston-Wilson, N. L., Sims, C. D., Hofmann, J. P., Anderson, L., Shore, A. D., Torrey, E. F., & Yolken, R. H. (2000). Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. Molecular Psychiatry, 5(2): 142149.CrossRefGoogle ScholarPubMed
Johnstone, T., Van Reekum, C. M., Urry, H. L., Kalin, N. H., & Davidson, R. J. (2007). Failure to regulate: Counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression. Journal of Neuroscience, 27(33): 88778884.CrossRefGoogle ScholarPubMed
Krishnan, K., Taylor, W. D., McQuoid, D. R., MacFall, J. R., Payne, M. E., Provenzale, J. M., & Steffens, D. C.(2004). Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression. Biological Psychiatry, 55(4): 390397.CrossRefGoogle ScholarPubMed
Kumar, A., Gupta, R. C., Albert, T. M., Alger, J., Wyckoff, N., & Hwang, S. (2004). Biophysical changes in normal-appearing white matter and subcortical nuclei in late-life major depression detected using magnetization transfer. Psychiatry Research: Neuroimaging, 130(2): 131140.CrossRefGoogle ScholarPubMed
Lee, R. S. C., Hermens, D. F., Porter, M. A., & Redoblado-Hodge, M. A. (2012). A meta-analysis of cognitive deficits in first-episode major depressive disorder. Journal of Affective Disorders, 140(2): 113124.CrossRefGoogle ScholarPubMed
Lui, S., Wu, Q., Qiu, L., Yang, X., Kuang, W., Chan, R. C. K., … Gong, Q. (2011). Resting-state functional connectivity in treatment-resistant depression. American Journal of Psychiatry, 168(6): 642648.CrossRefGoogle ScholarPubMed
Ma, N., Li, L., Shu, N., Liu, J., Gong, G., He, Z., … Zhang, Z. (2007). White matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder. American Journal of Psychiatry, 164(5): 823826.CrossRefGoogle ScholarPubMed
MacLeod, C., Mathews, A., & Tata, P. (1986). Attentional bias in emotional disorders. Journal of Abnormal Psychology, 95(1): 1520.CrossRefGoogle ScholarPubMed
Mayberg, H. S. (2009). Targeted electrode-based modulation of neural circuits for depression. Journal of Clinical Investigation, 119(4): 717725.CrossRefGoogle ScholarPubMed
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., … Lancaster, J. L. (1999). Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness. American Journal of Psychiatry, 156(5): 675682.CrossRefGoogle ScholarPubMed
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., … Kennedy, S. H. (2005). Deep brain stimulation for treatment-resistant depression. Neuron, 45(5): 651660.CrossRefGoogle ScholarPubMed
McCormick, L. M., Ponto, L. L. B., Pierson, R. K., Johnson, H. J., Magnotta, V., & Brumm, M. C. (2007). Metabolic correlates of antidepressant and antipsychotic response in patients with psychotic depression undergoing electroconvulsive therapy. Journal of ECT, 23(4): 265273.CrossRefGoogle ScholarPubMed
Millan, M. J., Agid, Y., Brüne, M., Bullmore, E. T., Carter, C. S., Clayton, N. S., … DeRubeis, R. J. (2012). Cognitive dysfunction in psychiatric disorders: Characteristics, causes and the quest for improved therapy. Nature Reviews Drug Discovery, 11(2): 141168.CrossRefGoogle ScholarPubMed
Minett, T. S. C., Dean, J. L., Firbank, M., English, P., & O’Brien, J. T. (2005). Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients. American Journal of Geriatric Psychiatry, 13(8): 665671.CrossRefGoogle ScholarPubMed
Modirrousta, M. & Fellows, L. K. (2008). Medial prefrontal cortex plays a critical and selective role in “feeling of knowing” meta-memory judgments. Neuropsychologia, 46(12): 29582965.CrossRefGoogle Scholar
Murata, T., Kimura, H., Omori, M., Kado, H., Kosaka, H., Iidaka, T., … Wada, Y. (2001). MRI white matter hyperintensities, 1H-MR spectroscopy and cognitive function in geriatric depression: A comparison of early-and late-onset cases. International Journal of Geriatric Psychiatry, 16(12): 11291135.CrossRefGoogle Scholar
Niogi, S., Mukherjee, P., Ghajar, J., & McCandliss, B. D. (2010). Individual differences in distinct components of attention are linked to anatomical variations in distinct white matter tracts. Frontiers in Neuroanatomy, 4: 2.Google ScholarPubMed
O’Driscoll, K. & Leach, J. P. (1998). “No longer Gage”: an iron bar through the head – early observations of personality change after injury to the prefrontal cortex. British Medical Journal, 317(7174): 16731674.Google ScholarPubMed
O’Sullivan, M., Barrick, T. R., Morris, R. G., Clark, C. A., & Markus, H. S. (2005). Damage within a network of white matter regions underlies executive dysfunction in CADASIL. Neurology, 65(10): 15841590.CrossRefGoogle ScholarPubMed
Papakostas, G. I., Iosifescu, D. V., Renshaw, P. F., Lyoo, I. K., Lee, H. K., Alpert, J. E., … Fava, M. (2005). Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (Part II). Psychiatry Research: Neuroimaging, 140(3): 301307.CrossRefGoogle ScholarPubMed
Ponds, R. W. H. M. & Jolles, J. (1996). Memory complaints in elderly people: The role of memory abilities, metamemory, depression, and personality. Educational Gerontology: An International Quarterly, 22(4): 341357.CrossRefGoogle Scholar
Posner, M. I. & Petersen, S. E. (1989). The attention system of the human brain: DTIC document. St. Louis, MO: Washington University.Google Scholar
Posner, M. I. & Rothbart, M. K. (2007). Research on attention networks as a model for the integration of psychological science. Annual Review of Psychology, 58: 123.CrossRefGoogle Scholar
Prins, N. D., Van Dijk, E. J., den Heijer, T., Vermeer, S. E., Jolles, J., Koudstaal, P. J., … Breteler, M. M. B. (2005). Cerebral small-vessel disease and decline in information processing speed, executive function and memory. Brain, 128(9): 20342041.CrossRefGoogle ScholarPubMed
Qin, J., Wei, M., Liu, H., Yan, R., Luo, G., Yao, Z., & Lu, Q. (2014). Abnormal brain anatomical topological organization of the cognitive-emotional and the frontoparietal circuitry in major depressive disorder. Magnetic Resonance in Medicine, 72(5): 13971407.CrossRefGoogle ScholarPubMed
Rajkowska, G. & Miguel-Hidalgo, J. J. (2007). Gliogenesis and glial pathology in depression. CNS & Neurological Disorders: Drug Targets, 6(3): 219233.CrossRefGoogle ScholarPubMed
Ratiu, P., Talos, I.-F., Haker, S., Lieberman, D., & Everett, P. (2004). The tale of Phineas Gage, digitally remastered. Journal of Neurotrauma, 21(5): 637643.CrossRefGoogle ScholarPubMed
Rigucci, S., Serafini, G., Pompili, M., Kotzalidis, G. D., & Tatarelli, R. (2010). Anatomical and functional correlates in major depressive disorder: The contribution of neuroimaging studies. World Journal of Biological Psychiatry, 11(2): 165180.CrossRefGoogle ScholarPubMed
Russo, S. J. & Nestler, E. J. (2013). The brain reward circuitry in mood disorders. Nature Reviews Neuroscience, 14(9): 609625.CrossRefGoogle ScholarPubMed
Sacher, J., Neumann, J., Fünfstück, T., Soliman, A., Villringer, A., & Schroeter, M. L. (2012). Mapping the depressed brain: A meta-analysis of structural and functional alterations in major depressive disorder. Journal of Affective Disorders, 140(2): 142148.CrossRefGoogle Scholar
Sepulcre, J., Masdeu, J. C., Sastre-Garriga, J., Goñi, J., Vélez-de-Mendizábal, N., Duque, B., … Villoslada, P. (2008). Mapping the brain pathways of declarative verbal memory: Evidence from white matter lesions in the living human brain. Neuroimage, 42(3): 12371243.CrossRefGoogle ScholarPubMed
Sheline, Y. I., Price, J. L., Yan, Z., & Mintun, M. A. (2010). Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proceedings of the National Academy of Sciences of the United States of America, 107(24): 1102011025.CrossRefGoogle ScholarPubMed
Shizukuishi, T., Abe, O., & Aoki, S. (2013). Diffusion tensor imaging analysis for psychiatric disorders. Magnetic Resonance in Medical Sciences, 12(3): 153159.CrossRefGoogle ScholarPubMed
Siegle, G. J., Thompson, W., Carter, C. S., Steinhauer, S. R., & Thase, M. E. (2007). Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: Related and independent features. Biological Psychiatry, 61(2): 198209.CrossRefGoogle ScholarPubMed
Simpson, J. E., Hosney, O., Wharton, S. B., Heath, P., Holden, H., Fernando, M. S., … Ince, P. G. (2009). Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways. Stroke, 40(2): 369375.CrossRefGoogle ScholarPubMed
Surguladze, S., Brammer, M. J., Keedwell, P., Giampietro, V., Young, A. W., Travis, M. J., … Phillips, M. L. (2005). A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biological Psychiatry, 57(3): 201209.CrossRefGoogle ScholarPubMed
Tao, H., Guo, S., Ge, T., Kendrick, K. M., Xue, Z., Liu, Z., & Feng, J. (2011). Depression uncouples brain hate circuit. Molecular Psychiatry, 18(1): 101111.CrossRefGoogle ScholarPubMed
Taylor, W. D., Aizenstein, H. J., & Alexopoulos, G. S. (2013). The vascular depression hypothesis: Mechanisms linking vascular disease with depression. Molecular Psychiatry, 18(9): 963974.CrossRefGoogle ScholarPubMed
Tham, M. W., Woon, P. S., Sum, M. Y., Lee, T.-S., & Sim, K. (2011). White matter abnormalities in major depression: Evidence from post-mortem, neuroimaging and genetic studies. Journal of Affective Disorders, 132(1): 2636.CrossRefGoogle ScholarPubMed
Thomas, A. J., O’Brien, J. T., Davis, S., Ballard, C., Barber, R., Kalaria, R. N., & Perry, R. H. (2002). Ischemic basis for deep white matter hyperintensities in major depression: A neuropathological study. Archives of General Psychiatry, 59(9): 785792.CrossRefGoogle ScholarPubMed
Tullberg, M., Fletcher, E., DeCarli, C., Mungas, D., Reed, B. R., Harvey, D. J., … Jagust, W. J. (2004). White matter lesions impair frontal lobe function regardless of their location. Neurology, 63(2): 246253.CrossRefGoogle ScholarPubMed
Turken, A. U., Whitfield-Gabrieli, S., Bammer, R., Baldo, J., Dronkers, N. F., & Gabrieli, J. D. E. (2008). Cognitive processing speed and the structure of white matter pathways: Convergent evidence from normal variation and lesion studies. NeuroImage, 42(2): 10321044.CrossRefGoogle ScholarPubMed
Van den Heuvel, D. M. J., Ten Dam, V. H., de Craen, A. J. M., Admiraal-Behloul, F., Olofsen, H., Bollen, E. L. E. M., … Westendorp, R. G. J. (2006). Increase in periventricular white matter hyperintensities parallels decline in mental processing speed in a non-demented elderly population. Journal of Neurology, Neurosurgery, and Psychiatry, 77(2): 149153.CrossRefGoogle Scholar
Van Horn, J. D., Irimia, A., Torgerson, C. M., Chambers, M. C., Kikinis, R., & Toga, A. W. (2012). Mapping connectivity damage in the case of Phineas Gage. PloS One, 7(5): e37454.CrossRefGoogle ScholarPubMed
Van Petten, C., Plante, E., Davidson, P. S. R., Kuo, T. Y., Bajuscak, L., & Glisky, E. L. (2004). Memory and executive function in older adults: Relationships with temporal and prefrontal gray matter volumes and white matter hyperintensities. Neuropsychologia, 42(10): 13131335.CrossRefGoogle ScholarPubMed
Veer, I. M., Beckmann, C. F., Van Tol, M.-J., Ferrarini, L., Milles, J., Veltman, D. J., … Rombouts, S. A. R. B. (2010). Whole brain resting-state analysis reveals decreased functional connectivity in major depression. Frontiers in Systems Neuroscience, 4: 41.CrossRefGoogle ScholarPubMed
Walther, S., Hügli, S., Höfle, O., Federspiel, A., Horn, H., Bracht, T., … Müller, T. J. (2012). Frontal white matter integrity is related to psychomotor retardation in major depression. Neurobiology of Disease,47(1): 1319.CrossRefGoogle ScholarPubMed
Watkins, E. & Brown, R. G. (2002). Rumination and executive function in depression: An experimental study. Journal of Neurology, Neurosurgery, and Psychiatry, 72(3): 400402.CrossRefGoogle ScholarPubMed
World Health Organization (2001). Mental Health: A Call for Action by World Health Ministers. Geneva: WHO.Google Scholar
Zou, K., Huang, X., Li, T., Gong, Q., Li, Z., Ou-yang, L., … Sun, X. (2008). Alterations of white matter integrity in adults with major depressive disorder: A magnetic resonance imaging study. Journal of Psychiatry & Neuroscience, 33(6): 525530.Google ScholarPubMed

References

Abbatecola, A. M., Paolisso, G., Lamponi, M., Bandinelli, S., Lauretani, F., Launer, L., & Ferrucci, L. (2004). Insulin resistance and executive dysfunction in older persons. Journal of the American Geriatrics Society, 52(10): 17131718.CrossRefGoogle ScholarPubMed
Adriaanse, M. C., Dekker, J. M., Nijpels, G., Heine, R. J., Snoek, F. J., & Pouwer, F. (2006). Associations between depressive symptoms and insulin resistance: The Hoorn Study. Diabetologia, 49(12): 28742877.CrossRefGoogle ScholarPubMed
Akomolafe, A., Beiser, A., Meigs, J. B., Au, R., Green, R. C., Farrer, L. A., … Seshadri, S. (2006). Diabetes mellitus and risk of developing Alzheimer disease: Results from the Framingham Study. Archives of Neurology, 63(11): 15511555.CrossRefGoogle ScholarPubMed
Anttila, S. & Leinonen, E. (2001). A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Reviews, 7(3): 239264.CrossRefGoogle ScholarPubMed
Arroyo, C., Hu, F., Ryan, L., Kawachi, I., Colditz, G., Speizer, F., & Manson, J. (2004). Depressive symptoms and risk of type 2 diabetes in women. Diabetes Care, 27(1): 129133.CrossRefGoogle ScholarPubMed
Awad, N., Gagnon, M., Desrochers, A., Tsiakas, M., & Messier, C. (2002). Impact of peripheral glucoregulation on memory. Behavioral Neuroscience, 116(4): 691702.CrossRefGoogle ScholarPubMed
Awad, N., Gagnon, M., & Messier, C. (2004). The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function. Journal of Clinical and Experimental Neuropsychology, 26(8): 10441080.CrossRefGoogle ScholarPubMed
Banki, C. M., Karmacsi, L., Bissette, G., & Nemeroff, C. B. (1992). CSF corticotropin-releasing hormone and somatostatin in major depression: Response to antidepressant treatment and relapse. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 2(2): 107113.CrossRefGoogle ScholarPubMed
Benedict, C., Hallschmid, M., Hatke, A., Schultes, B., Fehm, H., Born, J., & Kern, W. (2004). Intranasal insulin improves memory in humans. Psychoneuroendocrinology, 29(10): 13261334.CrossRefGoogle ScholarPubMed
Benkert, O., Szegedi, A., & Kohnen, R. (2000). Mirtazapine compared with paroxetine in major depression. Journal of Clinical Psychiatry, 61(9): 656663.CrossRefGoogle ScholarPubMed
Bot, M., Pouwer, F., De Jonge, P., Nolan, J. J., Mari, A., Hojlund, K., … Dekker, J. M. (2013). Depressive symptoms, insulin sensitivity and insulin secretion in the RISC cohort study. Diabetes & Metabolism, 39(1): 4249.Google Scholar
Boyer, W. & Feighner, J. (1992). An overview of paroxetine. Journal of Clinical Psychiatry, 53(Suppl.): 36.Google ScholarPubMed
Brown, L., Majumdar, S., Newman, S., & Johnson, J. (2005). History of depression increases risk of type 2 diabetes in younger adults. Diabetes Care, 28(5): 10631067.CrossRefGoogle ScholarPubMed
Bruehl, H., Sweat, V., Hassenstab, J., Polyakov, V., & Convit, A. (2010). Cognitive impairment in nondiabetic middle-aged and older adults is associated with insulin resistance. Journal of Clinical and Experimental Neuropsychology, 32(5): 487493.CrossRefGoogle ScholarPubMed
Carnethon, M., Kinder, L., Fair, J., Stafford, R., & Fortmann, S. (2003). Symptoms of depression as a risk factor for incident diabetes: findings from the National Health and Nutrition Examination Epidemiologic Follow-up Study, 1971–1992. American Journal of Epidemiology, 158(5): 416423.CrossRefGoogle ScholarPubMed
Casper, R., Davis, J., Pandey, G., Garver, D., & Dekirmenjian, H. (1977). Neuroendocrine and amine studies in affective illness. Psychoneuroendocrinology, 2(2): 105113.CrossRefGoogle ScholarPubMed
Centers for Disease Control and Prevention (2011). National diabetes fact sheet: National estimates and general information on diabetes and prediabetes in the United States. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention.Google Scholar
Cheng, B. & Mattson, M. (1992). IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage. Journal of Neuroscience, 12(4): 15581566.CrossRefGoogle ScholarPubMed
Chiba, M., Suzuki, S., Hinokio, Y., Hirai, M., Satoh, Y., Tashiro, A., … Toyota, T. (2000). Tyrosine hydroxylase gene microsatellite polymorphism associated with insulin resistance in depressive disorder. Metabolism, 49(9): 11451149.CrossRefGoogle ScholarPubMed
Clarke, D., Boyd, F., Kappy, M., & Raizada, M. (1984). Insulin binds to specific receptors and stimulates 2-deoxy-D-glucose uptake in cultured glial cells from rat brain. Journal of Biological Chemistry, 259: 1167211675.CrossRefGoogle ScholarPubMed
Convit, A., Wolf, O. T., Tarshish, C., & de Leon, M. J. (2003). Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly. Proceedings of the National Academy of Sciences of the United States of America, 100(4): 20192022.CrossRefGoogle ScholarPubMed
Craft, S. (2005). Insulin resistance syndrome and Alzheimer’s disease: Age- and obesity-related effects on memory, amyloid, and inflammation. Neurobiology of Aging, 26(Suppl. 1): 6569.CrossRefGoogle ScholarPubMed
Craft, S.S. (2006). Insulin resistance syndrome and Alzheimer disease: Pathophysiologic mechanisms and therapeutic implications. Alzheimer Disease and Associated Disorders, 20(4): 298301.CrossRefGoogle ScholarPubMed
Craft, S.S. (2009). The role of metabolic disorders in Alzheimer disease and vascular dementia: Two roads converged. Archives of Neurology, 66(3): 300305.CrossRefGoogle ScholarPubMed
Craft, S., Asthana, S., Cook, D., Baker, L., Cherrier, M., Purganan, K., … Krohn, A. J. (2003). Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer’s disease: Interactions with apolipoprotein E genotype. Psychoneuroendocrinology, 28(6): 809822.CrossRefGoogle ScholarPubMed
Craft, S., Asthana, S., Schellenberg, G., Baker, L., Cherrier, M., Boyt, A., … Plymate, S. (2000). Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer’s disease differ according to apolipoprotein-E genotype. Annals of the New York Academy of Sciences, 903: 222228.CrossRefGoogle ScholarPubMed
Craft, S., Asthana, S., Schellenberg, G., Cherrier, M., Baker, L., Newcomer, J., … Grimwood, K. (1999). Insulin metabolism in Alzheimer’s disease differs according to apolipoprotein E genotype and gender. Neuroendocrinology, 70(2): 146152.CrossRefGoogle ScholarPubMed
Craft, S. & Watson, G. (2004). Insulin and neurodegenerative disease: Shared and specific mechanisms. Lancet Neurology, 3(3): 169178.CrossRefGoogle ScholarPubMed
Curb, J. D., Rodriguez, B. L., Abbott, R. D., Petrovitch, H., Ross, G. W., Masaki, K. H., … White, L. R. (1999). Longitudinal association of vascular and Alzheimer’s dementias, diabetes, and glucose tolerance. Neurology, 52(5): 971975.CrossRefGoogle ScholarPubMed
Davis, S., Colburn, C., Dobbins, R., Nadeau, S., Neal, D., & Williams, P. (1995). Evidence that the brain of the conscious dog is insulin sensitive. Journal of Clinical Investigation, 95(2): 593602.CrossRefGoogle ScholarPubMed
de Leon, M., Desanti, S., Zinkowski, R., Mehta, P., Pratico, D., Segal, S., … Rusinek, H. (2004). MRI and CSF studies in the early diagnosis of Alzheimer’s disease. Journal of Internal Medicine, 256(3): 205223.CrossRefGoogle ScholarPubMed
Delaunay, F., Khan, A., Cintra, A., Davani, B., Ling, Z. C., Andersson, A., … Okret, S. (1997). Pancreatic beta cells are important targets for the diabetogenic effects of glucocorticoids. Journal of Clinical Investigation, 100(8): 20942098.CrossRefGoogle ScholarPubMed
den Heijer, T., Vermeer, S., van Dijk, E., Prins, N., Koudstaal, P., Hofman, A., & Breteler, M. M. (2003). Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI. Diabetologia, 46(12): 16041610.CrossRefGoogle ScholarPubMed
Dringen, R. & Hamphrecht, B. (1992). Glucose, insulin, and insulin-like growth factor I regulate the glycogen content of atroglia-rich primary cultures. Journal of Neurochemistry, 58(2): 511517.CrossRefGoogle ScholarPubMed
Dunaif, A., Segal, K., Futterweit, W., & Dobrjansky, A. (1989). Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes, 38(9): 11651174.CrossRefGoogle ScholarPubMed
Eaton, W., Armenian, H., Gallo, J., Pratt, L., & Ford, D. (1996). Depression and risk for onset of type II diabetes: A prospective population-based study. Diabetes Care 19(10): 10971102.CrossRefGoogle ScholarPubMed
Enzinger, C., Fazekas, F., Matthews, P., Ropele, S., Schmidt, H., Smith, S., … Schmidt, R. (2005). Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Neurology, 64(10): 17041711.Google Scholar
Everson-Rose, S., Meyer, P., Powell, L., Pandey, D., Torrens, J., Kravitz, H., … Matthews, K. A. (2004). Depressive symptoms, insulin resistance, and risk of diabetes in women at midlife. Diabetes Care, 27(12): 28562862.CrossRefGoogle ScholarPubMed
Facchini, F., Hua, N., Abbasi, F., & Reaven, G. (2001). Insulin resistance as a predictor of age-related diseases. Journal of Clinical Endocrinology & Metabolism, 86(8): 35743578.CrossRefGoogle ScholarPubMed
Farin, H., Abbasi, F., & Reaven, G. (2005). Body mass index and waist circumference correlate to the same degree with insulin-mediated glucose uptake. Metabolism, 54(10): 13231328.CrossRefGoogle Scholar
Farin, H., Abbasi, F., & Reaven, G. (2006). Body mass index and waist circumference both contribute to differences in insulin-mediated glucose disposal in nondiabetic adults. American Journal of Clinical Nutrition, 83(1): 4751.CrossRefGoogle ScholarPubMed
Fava, M. (2000). Weight gain and antidepressants. Journal of Clinical Psychiatry, 61(Suppl. 11): 3741.Google ScholarPubMed
Flood, J., Mooradian, A., & Morley, J. (1990). Characteristics of learning and memory in streptozocin-induced diabetic mice. Diabetes, 39(11): 13911398.CrossRefGoogle ScholarPubMed
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005). The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proceedings of the National Academy of Sciences of the United States of America, 102(27): 96739678.CrossRefGoogle ScholarPubMed
Freeman, H. (1946). Resistance to insulin in mentally disturbed soldiers. Archives of Neural Psychiatry, 56(1): 7478.CrossRefGoogle ScholarPubMed
Gerich, J. (2003). Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus. Mayo Clinic Proceedings, 78(4): 447456.CrossRefGoogle Scholar
Geroldi, C., Frisoni, G. B., Paolisso, G., Bandinelli, S., Lamponi, M., & Abbatecola, A. M. (2005). Insulin resistance in cognitive impairment: The InCHIANTI study. Archives of Neurology, 62(7): 10671072.CrossRefGoogle ScholarPubMed
Gerozissis, K. (2003). Brain insulin: Regulation, mechanisms of action and functions. Cellular and Molecular Neurobiology, 23(1): 125.CrossRefGoogle ScholarPubMed
Gispen, W. & Biessels, G. (2000). Cognition and synaptic plasticity in diabetes mellitus. Trends in Neurosciences, 23(11): 542549.CrossRefGoogle ScholarPubMed
Golden, S., Williams, J., Ford, D., Yeh, H., Paton Sanford, C., Nieto, F., … Atherosclerosis Risk in Communities study (2004). Depressive symptoms and the risk of type 2 diabetes: the Atherosclerosis Risk in Communities study. Diabetes Care, 27(2): 429435.CrossRefGoogle ScholarPubMed
Goodnick, P. (2001). Use of antidepressants in treatment of comorbid diabetes mellitus and depression as well as in diabetic neuropathy. Annals of Clinical Psychiatry, 13(1): 3141.CrossRefGoogle ScholarPubMed
Green, R., Cupples, L., Kurz, A., Auerbach, S., Go, R., Sadovnick, D., … Farrer, L. (2003). Depression as a risk factor for Alzheimer disease: The MIRAGE Study. Archives of Neurology, 60(5): 753759.CrossRefGoogle ScholarPubMed
Greicius, M., Srivastava, G., Reiss, A., & Menon, V. (2004). Default-mode network activity distinguishes Alzheimer’s disease from healthy aging: Evidence from functional MRI. Proceedings of the National Academy of Sciences of the United States of America, 101(13): 46374642.CrossRefGoogle ScholarPubMed
Hampel, H., Burger, K., Teipel, S. J., Bokde, A. L., Zetterberg, H., & Blennow, K. (2008). Core candidate neurochemical and imaging biomarkers of Alzheimer’s disease. Alzheimer’s & Dementia: Journal of the Alzheimer’s Association, 4(1): 3848.CrossRefGoogle ScholarPubMed
Hempel, R., Onopa, R., & Convit, A. (2012). Type 2 diabetes affects hippocampus volume differentially in men and women. Diabetes/Metabolism Research and Reviews, 28(1): 7683.CrossRefGoogle ScholarPubMed
Hill, J., Lesniak, M., Pert, C., & Roth, J. (1986). Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas. Neuroscience, 17(4): 11271138.CrossRefGoogle ScholarPubMed
Horacek, J., Kuzmiakova, M., Hoschl, C., Andel, M., & Bahbonh, R. (1999). The relationship between central serotonergic activity and insulin sensitivity in healthy volunteers. Psychoneuroendocrinology, 24(8): 785797.CrossRefGoogle ScholarPubMed
Izumi, Y., Yamada, K., Matsukawa, M., & Zorumski, C. (2003). Effects of insulin on long-term potentiation in hippocampal slices from diabetic rats. Diabetologia, 46(7): 10071012.CrossRefGoogle ScholarPubMed
Kalmijn, S., Feskens, E., Launer, L., Stijnen, T., & Kromhout, D. (1995). Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men. Diabetologia, 38(9): 10961102.CrossRefGoogle Scholar
Kanaya, A. M., Barrett-Connor, E., Gildengorin, G., & Yaffe, K. (2004). Change in cognitive function by glucose tolerance status in older adults: A 4-year prospective study of the Rancho Bernardo study cohort. Archives of Internal Medicine, 164(12): 13271333.CrossRefGoogle ScholarPubMed
Kawakami, N., Takatsuka, N., Shimizu, H., & Ishibashi, H. (1999). Depressive symptoms and occurrence of type 2 diabetes among Japanese men. Diabetes Care, 22(7): 10711076.CrossRefGoogle ScholarPubMed
Kenna, H., Hoeft, F., Kelley, R., Wroolie, T., DeMuth, B., Reiss, A., & Rasgon, N. (2013). Fasting plasma insulin and the default mode network in women at risk for Alzheimer’s disease. Neurobiology of Aging, 34(3): 641649.CrossRefGoogle ScholarPubMed
Kern, W., Peters, A., Fruehwald-Schultes, B., Deininger, E., Born, J., & Fehm, H. (2001). Improving influence of insulin on cognitive functions in humans. Neuroendocrinology, 74(4): 270280.CrossRefGoogle ScholarPubMed
Kerr, D., Stanley, J., Barron, M., Thomas, R., Leatherdale, B., & Pickard, J. (1993). Symmetry of cerebral blood flow and cognitive responses to hypoglycemia in humans. Diabetologia, 36(1): 7378.CrossRefGoogle ScholarPubMed
Kessing, L., Nilsson, F., Siersma, V., & Andersen, P. (2004). Increased risk of developing diabetes in depressive and bipolar disorders? Journal of Psychiatric Research, 38(4): 395402.CrossRefGoogle ScholarPubMed
Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kareholt, I., Winblad, B., … Nissinen, A. (2005). Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Archives of Neurology 62(10): 15561560.CrossRefGoogle ScholarPubMed
Kopf, D., Westphal, S., Luley, C., Ritter, S., Gilles, M., Weber-Hamann, B., … Deuschle, M. (2004). Lipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism, and antidepressant treatment. Journal of Clinical Psychopharmacology, 24(5): 527531.CrossRefGoogle ScholarPubMed
Kopf, S. & Baratti, C. (1995). The impairment of retention induced by insulin in mice may be mediated by a reduction in central cholinergic activity. Neurobiology of Learning and Memory, 63(3): 220228.CrossRefGoogle ScholarPubMed
Kopf, S. & Baratti, C. (1996). Memory modulation by post-training glucose or insulin remains evident at long retention intervals. Neurobiology of Learning and Memory, 65(2): 189191.CrossRefGoogle ScholarPubMed
Kumar, R., Anstey, K. J., Cherbuin, N., Wen, W., & Sachdev, P. S. (2008). Association of type 2 diabetes with depression, brain atrophy, and reduced fine motor speed in a 60- to 64-year-old community sample. American Journal of Geriatric Psychiatry, 16(12): 989998.CrossRefGoogle Scholar
Kumari, M., Head, J., & Marmot, M. (2004). Prospective study of social and other risk factors for incidence of type 2 diabetes in the Whitehall II study. Archives of Internal Medicine, 164(17): 18731880.CrossRefGoogle ScholarPubMed
Kuusisto, J., Koivisto, K., Mykkanen, L., Helkala, E., Vanhanen, M., Hänninen, T., … Laakso, M. (1997). Association between features of the insulin resistance syndrome and Alzheimer’s disease independently of apolipoprotein E4 phenotype: cross sectional population based study. British Medical Journal, 315(7115): 10451049.CrossRefGoogle ScholarPubMed
Kyriaki, G. (2003). Brain insulin: Regulation, mechanisms of action and functions. Cellular and Molecular Neurobiology, 23(1): 125.Google Scholar
Lannert, H. & Hoyer, S. (1998). Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behavioral Neuroscience, 112(5): 11991208.CrossRefGoogle ScholarPubMed
Luchsinger, J. A. (2010). Diabetes, related conditions, and dementia. Journal of the Neurological Sciences, 299(1–2): 3538.CrossRefGoogle ScholarPubMed
Luchsinger, J. A., Tang, M., Shea, S., & Mayeux, R. (2004). Hyperinsulinemia and risk of Alzheimer disease. Neurology, 63(7): 11871992.CrossRefGoogle ScholarPubMed
Ma, Y., Balasubramanian, R., Pagoto, S. L., Schneider, K. L., Hebert, J. R., Phillips, L. S., … Liu, S. (2013). Relations of depressive symptoms and antidepressant use to body mass index and selected biomarkers for diabetes and cardiovascular disease. American Journal of Public Health, 103(8): e34e43.CrossRefGoogle ScholarPubMed
Matthews, D., Hosker, J., Rudenski, A., Naylor, B., Treacher, D., & Turner, R. (1985). Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7): 412419.CrossRefGoogle ScholarPubMed
McCowan, P. & Quastel, J. (1931). Blood sugar studies in abnormal mental states. British Journal of Psychiatry, 77(318): 525548.Google Scholar
McIntyre, R. S., Rasgon, N. L., Kemp, D. E., Nguyen, H. T., Law, C. W., Taylor, V. H., … Goldstein, B. I. (2009). Metabolic syndrome and major depressive disorder: co-occurrence and pathophysiologic overlap. Current Diabetes Reports, 9(1): 5159.CrossRefGoogle ScholarPubMed
McLaughlin, T., Allison, G., Abbasi, F., Lamendola, C., & Reaven, G. (2004). Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals. Metabolism, 53(4): 495499.CrossRefGoogle ScholarPubMed
Mellitus ECotDaCoD (2003). Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care, 26(Suppl. 1): S5S20.CrossRefGoogle Scholar
Menna-Perper, M., Rochford, J., Mueller, P., Swartzburg, M., Jekelis, A., & Manowitz, P. (1984). Differential response of plasma glucose, amino acids and nonesterified fatty acids to insulin in depressed patients. Psychoneuroendocrinology, 9(2): 161171.CrossRefGoogle ScholarPubMed
Messier, C. (2003). Diabetes, Alzheimer’s disease and apolipoprotein genotype. Experimental Gerontology, 38(9): 941946.CrossRefGoogle ScholarPubMed
Mueller, P., Heninger, G., & McDonald, R. (1969a). Insulin tolerance test in depression. Archives of General Psychiatry, 21: 587594.CrossRefGoogle ScholarPubMed
Mueller, P., Heninger, G., & McDonald, R. (1969b). Intravenous glucose tolerance test in depression. Archives of General Psychiatry, 21: 470477.CrossRefGoogle ScholarPubMed
Muldoon, M., Mackey, R., Korytkowski, M., Flory, J., Pollock, B., & Manuck, S. (2006). The metabolic syndrome is associated with reduced central serotonergic responsivitity in healthy community volunteers. Journal of Clinical Endocrinology & Metabolism, 91(2): 718721.Google Scholar
Muldoon, M., Mackey, R., Williams, K., Korytkowski, M., Flory, J., & Manuck, S. (2004). Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity. Journal of Clinical Endocrinology & Metabolism, 89(1): 266271.CrossRefGoogle ScholarPubMed
Musen, G., Jacobson, A. M., Bolo, N. R., Simonson, D. C., Shenton, M. E., McCartney, R. L., … Hoogenboom, W. S. (2012). Resting-state brain functional connectivity is altered in type 2 diabetes. Diabetes, 61(9): 23752379.CrossRefGoogle ScholarPubMed
Musselman, D. L., Betan, E., Larsen, H., & Phillips, L. S. (2003). Relationship of depression to diabetes types 1 and 2: Epidemiology, biology, and treatment. Biological Psychiatry, 54(3): 317329.CrossRefGoogle ScholarPubMed
Nathan, R., Sachar, E., Asnis, G., Halbreich, U., & Halpern, F. (1981). Relative insulin insensitivity and cortisol secretion in depressed patients. Psychiatry Research, 4(3): 291300.CrossRefGoogle ScholarPubMed
Neumann, K. F., Rojo, L., Navarrete, L. P., Farias, G., Reyes, P., & Maccioni, R. B. (2008). Insulin resistance and Alzheimer’s disease: Molecular links & clinical implications. Current Alzheimer Research, 5(5): 438447.CrossRefGoogle ScholarPubMed
Nichols, G. & Brown, J. (2003). Unadjusted and adjusted prevalence of diagnosed depression in type 2 diabetes. Diabetes Care, 26(3): 744749.CrossRefGoogle ScholarPubMed
Okamura, F., Tashiro, A., Utumi, A., Imai, T., Suchi, T., Tamura, D., … Hongo, M. (2000). Insulin resistance in patients with depression and its changes during the clinical course of depression: minimal model analysis. Metabolism, 49(10): 12551260.CrossRefGoogle ScholarPubMed
Ott, A., Stolk, R. P., Hofman, A., van Harskamp, F., Grobbee, D. E., & Breteler, M. M. (1996). Association of diabetes mellitus and dementia: The Rotterdam Study. Diabetologia, 39(11): 13921397.CrossRefGoogle ScholarPubMed
Palinkas, L., Lee, P., & Barrett-Connor, E. (2004). A prospective study of Type 2 diabetes and depressive symptoms in the elderly: The Rancho Bernardo Study. Diabetic Medicine, 21(11): 11851191.CrossRefGoogle ScholarPubMed
Pan, A., Ye, X., Franco, O. H., Li, H., Yu, Z., Zou, S., … Lin, X. (2008). Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: Findings from the Nutrition and Health of Aging Population in China Study. Journal of Affective Disorders, 109(1–2): 7582.CrossRefGoogle ScholarPubMed
Pariante, C. M. & Lightman, S. L. (2008). The HPA axis in major depression: Classical theories and new developments. Trends in Neurosciences, 31(9): 464468.CrossRefGoogle ScholarPubMed
Park, C. (2001). Cognitive effects of insulin in the central nervous system. Neuroscience and Biobehavioral Reviews, 25(4): 311323.CrossRefGoogle ScholarPubMed
Park, C., Seeley, R., Craft, S., & Woods, S. (2000). Intracerebroventricular insulin enhances memory in a passive-avoidance task. Physiology & Behavior 68(4): 509514.CrossRefGoogle Scholar
Pearson, S., Schmidt, M., Patton, G., Dwyer, T., Blizzard, L., Otahal, P., & Venn, A. (2010). Depression and insulin resistance: Cross-sectional associations in young adults. Diabetes Care, 33(5): 11281133.CrossRefGoogle ScholarPubMed
Pestell, R., Crock, P., & Ward, G. (1989). Fenfluramine increases insulin action in patients with NIDDM. Diabetes Care, 12(4): 252258.CrossRefGoogle ScholarPubMed
Porte, D. Jr. & Woods, S. C. (1981). Regulation of food intake and body weight in insulin. Diabetologia, 20(Suppl.): 274280.CrossRefGoogle ScholarPubMed
Potter Van Loon, B., Radder, J., Krans, H., Zwinderman, A., & Meinders, A. (1991). Fluoxetine increases insulin action in obese nondiabetic and obese non-insulin-dependent diabetic individuals. International Journal of Obesity and Related Metabolic Disorders, 16(2): 7885.Google Scholar
Pryce, I. (1958). Melancholia, glucose tolerance, and bodyweight. Journal of Mental Science, 104(435): 421427.CrossRefGoogle Scholar
Ramasubbu, R. (2002). Insulin resistance: A metabolic link between depressive disorder and atherosclerotic vascular diseases. Medical Hypotheses, 59(5): 537551.CrossRefGoogle ScholarPubMed
Rasgon, N., Altshuler, L., Fairbanks, L., Elman, S., Bitran, J., Labarca, R., … Mintz, J. (2005). Reproductive function and risk for PCOS in women treated for bipolar disorder. Bipolar Disorders, 7(3): 246259.CrossRefGoogle ScholarPubMed
Rasgon, N. & Jarvik, L. (2004). Insulin resistance, affective disorders, and Alzheimer’s disease: Review and hypothesis. Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 59(2): 178183.CrossRefGoogle ScholarPubMed
Rasgon, N. L., Carter, M. S., Elman, S., Bauer, M., Love, M., & Korenman, S. G. (2002). Common treatment of polycystic ovarian syndrome and major depressive disorder: Case report and review. Current Drug Targets: Immune Endocrine & Metabolic Disorders, 2(1): 97102.Google ScholarPubMed
Rasgon, N. L., Kenna, H. A., Wroolie, T. E., Kelley, R., Silverman, D., Brooks, J., … Reiss, A. (2011). Insulin resistance and hippocampal volume in women at risk for Alzheimer’s disease. Neurobiology of Aging, 32(11): 19421948.CrossRefGoogle ScholarPubMed
Rasgon, N. L., Kenna, H. A., Wroolie, T. E., Williams, K. E., DeMuth, B. N., & Silverman, D. H. (2014). Insulin resistance and medial prefrontal gyrus metabolism in women receiving hormone therapy. Psychiatry Research, 223(1): 2836.CrossRefGoogle ScholarPubMed
Rasgon, N. L., Rao, R. C., Hwang, S., Altshuler, L. L., Elman, S., Zuckerbrow-Miller, J., & Korenman, S. G. (2003). Depression in women with polycystic ovary syndrome: clinical and biochemical correlates. Journal of Affective Disorders, 74(3): 299304.CrossRefGoogle ScholarPubMed
Reaven, G. (1988). Banting Lecture 1988: Role of insulin resistance in human disease. Diabetes, 37(12): 15951607.CrossRefGoogle ScholarPubMed
Reaven, G.G. (1992). Syndrome X. Blood Pressure Supplement, 4: 1316.Google ScholarPubMed
Reaven, G.G. (1993). Role of insulin resistance in human disease. Annual Review of Medicine, 44: 121131.CrossRefGoogle ScholarPubMed
Reaven, G.G. (2005). All obese individuals are not created equal: Insulin resistance is the major determinant of cardiovascular disease in overweight/obese individuals. Diabetes & Vascular Disease Research, 2(3): 105112.CrossRefGoogle ScholarPubMed
Roos, C., Lidfeldt, J., Agardh, C. D., Nyberg, P., Nerbrand, C., Samsioe, G., & Westrin, A. (2007). Insulin resistance and self-rated symptoms of depression in Swedish women with risk factors for diabetes: the Women’s Health in the Lund Area study. Metabolism, 56(6): 825829.CrossRefGoogle ScholarPubMed
Rosmond, R., Bouchard, C., & Bjorntorp, P. (2002). Increased abdominal obesity in subjects with a mutation in the 5-HT(2A) receptor gene promoter. Annals of the New York Academy of Sciences, 967: 571575.CrossRefGoogle ScholarPubMed
Sachar, E., Finkelstein, J., & Hellman, L. (1971). Growth hormone responses in depressive illness. Archives of General Psychiatry, 25(3): 263269.CrossRefGoogle Scholar
Santucci, A., Schroeder, H., & Riccio, D. (1990). Homeostatic disruption and memory: Effect of insulin administration in rats. Behavioral and Neural Biology, 53(3): 321333.CrossRefGoogle ScholarPubMed
Scheen, A., Paolisso, G., Salvatore, T., & Lefèbvre, P. J. (1991). Improvement of insulin-induced glucose disposal in obese patients with NIDDM after 1-week treatment with D-fenfluramine. Diabetes Care, 14(4): 325332.CrossRefGoogle Scholar
Schulingkamp, R., Pagano, T., Hung, D., & Raffa, R. (2000). Insulin receptors and insulin action in the brain: Review and clinical implications. Neuroscience and Biobehavioral Reviews, 24(8): 855872.CrossRefGoogle ScholarPubMed
Schuur, M., Henneman, P., van Swieten, J. C., Zillikens, M. C., de Koning, I., Janssens, A. C., … Van Duijn, C. M. (2010). Insulin-resistance and metabolic syndrome are related to executive function in women in a large family-based study. European Journal of Epidemiology, 25(8): 561568.CrossRefGoogle Scholar
Schwarzberg, H., Bernstein, H., Reiser, M., & Gunther, O. (1989). Intracerebroventricular administration of insulin attenuates retrieval of a passive avoidance response in rats. Neuropeptides, 13(2): 7981.CrossRefGoogle ScholarPubMed
Sorg, C., Riedl, V., Muhlau, M., Calhoun, V. D., Eichele, T., Laer, L., … Wohlschläger, A. M. (2007). Selective changes of resting-state networks in individuals at risk for Alzheimer’s disease. Proceedings of the National Academy of Sciences of the United States of America, 104(47): 1876018765.CrossRefGoogle ScholarPubMed
Spaner, D., Bland, R., & Newman, S. (1994). Epidemiology of psychiatric disorders in Edmonton: major depressive disorder. Acta Psychiatrica Scandinavica Supplement,376: 715.CrossRefGoogle ScholarPubMed
Stolk, R., Breteler, M., Ott, A., Pols, H., Lamberts, S., Grobbee, D., & Hofman, A. (1997). Insulin and cognitive function in an elderly population: The Rotterdam Study. Diabetes Care, 20(5): 792795.CrossRefGoogle Scholar
Timonen, M., Laakso, M., Jokelainen, J., Rajala, U., Meyer-Rochow, V., & Keinanen-Kiukaanniemi, S. (2005). Insulin resistance and depression: Cross sectional study. British Medical Journal, 330(7481): 1718.CrossRefGoogle ScholarPubMed
Timonen, M., Salmenkaita, I., Jokelainen, J., Laakso, M., Harkonen, P., Koskela, P., … Keinänen-Kiukaanniemi, S. (2007). Insulin resistance and depressive symptoms in young adult males: Findings from Finnish military conscripts. Psychosomatic Medicine, 69(8): 723728.CrossRefGoogle Scholar
Unger, E., Kjellen, L., & Eriksson, U. J. (1991). Effect of insulin on the altered production of proteoglycans in rib cartilage of experimentally diabetic rats. Archives of Biochemistry and Biophysics, 285(2): 205210.CrossRefGoogle ScholarPubMed
Valastro, B., Cossette, J., Lavoie, N., Gagnon, S., Trudeau, F., & Massicotte, G. (2002). Up-regulation of glutamate receptors is associated with LTP defects in the early stages of diabetes mellitus. Diabetologia, 45(5): 642650.CrossRefGoogle ScholarPubMed
Van den Akker, M., Schuurman, A., Metsemakers, J., & Buntinx, F. (2004). Is depression related to subsequent diabetes mellitus? Acta Psychiatrica Scandinavica, 110(3): 178183.CrossRefGoogle ScholarPubMed
Vanhanen, M., Koivisto, K., Karjalainen, L., Helkala, E. L., Laakso, M., & Soininen, H. (1997). Risk for non-insulin-dependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function. Neuroreport, 8(6): 15271530.CrossRefGoogle ScholarPubMed
Vanhanen, M., Koivisto, K., Kuusisto, J., Mykkanen, L., Helkala, E., Hänninen, T., … Laakso, M. (1998). Cognitive function in an elderly population with persistent impaired glucose tolerance. Diabetes Care, 21(3): 398402.CrossRefGoogle Scholar
Vrbikova, J., Bendlova, B., Hill, M., Vankova, M., Vondra, K., & Starka, L. (2002). Insulin sensitivity and beta-cell function in women with polycystic ovary syndrome. Diabetes Care, 25(7): 12171222.CrossRefGoogle ScholarPubMed
Warram, J. H., Martin, B. C., Krolewski, A. S., Soeldner, J. S., & Kahn, C. R. (1990). Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Annals of Internal Medicine, 113(12): 909915.CrossRefGoogle ScholarPubMed
Watson, G. & Craft, S. (2004). Modulation of memory by insulin and glucose: Neuropsychological observations in Alzheimer’s disease. European Journal of Pharmacology, 490(1–3): 97113.CrossRefGoogle ScholarPubMed
Weissman, M., Bland, R., Canino, G., Faravelli, C., Greenwald, S., Hwu, H., … Yeh, E.-K. (1996). Cross-national epidemiology of major depression and bipolar disorder. JAMA, 276(4): 293299.CrossRefGoogle ScholarPubMed
Werner, H., Raizada, M., Mudd, L., Foyt, H. L., Simpson, I., & Roberts, C. T. (1989). Regulation of rat brain/HepG2 glucose transporter gene expression by insulin and insulin-like growth factor-I in primary cultures of neuronal and glial cells. Endocrinology, 125(1): 314320.CrossRefGoogle ScholarPubMed
Winocur, G., Greenwood, C., Piroli, G., Grillo, C., Reznikov, L., & Reagan, L. (2005). Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity. Behavioral Neuroscience, 119(5): 13891395.CrossRefGoogle Scholar
Winokur, A., Maislin, G., Phillips, J., & Amsterdam, J. (1988). Insulin resistance after oral glucose tolerance testing in patients with major depression. American Journal of Psychiatry, 145(3): 325330.Google ScholarPubMed
Wright, J., Jacisin, J., Radin, N., & Bell, R. (1978). Glucose metabolism in unipolar depression. British Journal of Psychiatry, 132(386393).CrossRefGoogle ScholarPubMed
Wroolie, T. E., Kenna, H. A., Singh, M. K., & Rasgon, N. L. (2015). Association between insulin resistance and cognition in patients with depressive disorders: Exploratory analyses into age-specific effects. Journal of Psychiatric Research, 60: 6572.Google Scholar
Yaffe, K. (2007). Metabolic syndrome and cognitive decline. Current Alzheimer Research, 4(2): 123126.CrossRefGoogle ScholarPubMed
Yaffe, K., Blackwell, T., Kanaya, A., Davidowitz, N., Barrett-Connor, E., & Krueger, K. (2004). Diabetes, impaired fasting glucose, and development of cognitive impairment in older women. Neurology, 63(4): 658663.CrossRefGoogle ScholarPubMed
Yip, J., Facchini, F., & Reaven, G. (1998). Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease. Journal of Clinical Endocrinology & Metabolism 83: 27732776.CrossRefGoogle ScholarPubMed
Young, S. E., Mainous, A. G. III, & Carnemolla, M. (2006). Hyperinsulinemia and cognitive decline in a middle-aged cohort. Diabetes Care, 29(12): 26882693.CrossRefGoogle Scholar
Yuan, X., Yamada, K., Ishiyama-Shigemoto, S., Koyama, W., & Nonaka, K. (2000). Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetes. Diabetologia, 43(3): 373376.CrossRefGoogle ScholarPubMed
Zhao, W., Chen, H., Xu, H., Moore, E., Meiri, N., Quon, M., & Alkon, D. L. (1999). Brain insulin receptors and spatial memory: Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. Journal of Biological Chemistry, 274(49): 3489334902.CrossRefGoogle ScholarPubMed
Zhou, J., Greicius, M. D., Gennatas, E. D., Growdon, M. E., Jang, J. Y., Rabinovici, G. D., … Seeley, W. W. (2010). Divergent network connectivity changes in behavioural variant frontotemporal dementia and Alzheimer’s disease. Brain, 133(Pt 5): 13521367.CrossRefGoogle ScholarPubMed

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