This chapter examines the development of illuminated manuscripts in Late Antiquity, focusing on their origins, evolution and cultural significance. It argues that illumination was not merely decorative but played a navigational, didactic and symbolic role, aiding text comprehension while reinforcing religious and political authority. Tracing the transition from papyrus scrolls to the codex, the chapter emphasises how the Christian adoption of the codex format facilitated the rise of manuscript illumination. It documents how the earliest illustrated Christian manuscripts emerged in Egypt, influenced by pagan scroll traditions, magical texts and the Book of the Dead. These manuscripts incorporated symbolic elements such as the ankh cross and interlace designs, which later became defining features of Coptic and Byzantine carpet pages. The study then shifts focus to early biblical illustration, highlighting works such as the Vienna Genesis, Quedlinburg Itala and Rabbula Gospels, which reflect the growing role of visual storytelling in Christian texts. The chapter concludes by emphasising the imperial patronage of illuminated books, noting Constantine’s commissioning of grand scriptural manuscripts and the development of treasure bindings adorned with ivory and gold. Ultimately, the study demonstrates how manuscript illumination evolved as a medium of authority, devotion and intellectual transmission across Late Antiquity and the early medieval world.