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30 - Tooth development and regeneration

from Part V - Animal models and clinical applications

Published online by Cambridge University Press:  05 February 2015

By
Weibo Zhang  and
Pamela C. Yelick
Edited by
Peter X. Ma
Weibo Zhang
Affiliation:
Tufts University
Pamela C. Yelick
Affiliation:
Tufts University
Peter X. Ma
Affiliation:
University of Michigan, Ann Arbor
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Summary

Tooth development

Each tooth, even though it looks simple, is an organ with complex structure and consists of multiple types of tissues (Ten Cate, 1998). Dentin is the main component, which is a hard and avascular tissue with a small hollow tubular inside. Enamel is the hardest tissue of the whole living body, protecting the dentin underneath by covering the crown dentin. Cementum, including cellular and acellular cementum, is present on the surface of root dentin. Other than those three types of hard tissue, a tooth also contains dental pulp, the highly vascularized soft tissue that acts as nutrition source and biosensor, as well as periodontal ligament (PDL), the tissue with well-organized collagen bundles that anchors the tooth to the surrounding alveolar bone. Among those tissues, only enamel is from the epithelium. The rest of the dental tissues are all from the neural crest-cell-derived mesenchyme (Nanci, 2007). The sequential and reciprocal interactions between the oral epithelium and the cranial neural crest-derived mesenchyme are essential to control tooth formation, including their size, number, and shape (Thesleff and Nieminen, 1996).

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Biomaterials and Regenerative Medicine , pp. 555 - 569
Publisher: Cambridge University Press
Print publication year: 2014

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Save book to Dropbox

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Save book to Google Drive

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