The introduction provides an overview of the volume’s key theoretical concepts and empirical cases. It emphasizes that there have been a variety of antifascisms in Latin America and the Caribbean that were not merely derivative of European antifascism or the product of European exiles. Rather, there were homegrown Latin American and Caribbean antifascist movements forged in the interplay between local, regional, and transnational processes. By placing Latin American and Caribbean antifascists in relation to the broader historiography on antifascism, the introduction illuminates their specific heterogeneous agendas, strategies, and styles as well as their class, racial, ethnic, and gendered dimensions. Latin American and Caribbean antifascists participated in exchanges from the Global South to the Global North and within the Global South. They resembled and yet differed from other Global South antifascisms regarding race and imperialism. The introduction ends by providing an overview of the chapters by placing them within the book’s theoretical framework.