The adoption of the Deforestation-free Products Regulation represents a significant step forward in the protection of forests, both in the EU and in non-EU countries. In particular, it aims at minimising the risk of deforestation and forest degradation associated with products that contain, have been fed with, or have been made using certain commodities (cattle, cocoa, coffee, oil palm, rubber, soya, and wood). Environmental protection is achieved through provisions affecting the placing and making available of and export from the EU market of the relevant products, including a due diligence framework to ensure that such commodities are deforestation-free and legal under the law of the country of origin. While the Regulation has a clear environmental goal, it could also be seen as an operationalisation of the One Health approach as it tackles several drivers of environmental degradation (land-use change, biodiversity decline, and GHG emissions/climate change). In particular, this Regulation makes for a noteworthy case study in light of its extraterritorial reach, and it is examined in view of the unacknowledged ramifications for the One Health.