Affordable access to quality health and care is generally recognised as a basic human need and one of the grand challenges society currently faces, especially in the wake of the COVID-19 pandemic. Unfortunately, the focus on public health is driving a predominantly human-centric approach to One Health initiatives. Furthermore, the concerted reliance on innovation and technology-driven solutions may exacerbate the problem. Without the appropriate legal and policy framework to incentivise and capture the social value of research and innovation, there is a risk the resulting solutions will fail to achieve the balance between animal, environment, and human health. This chapter presents a legally supported approach, informed by the intellectual property framework and the policy objectives of Responsible Research and Innovation (RRI) and Value-Based Health and Care (VBHC) principles, to support the implementation of a true One Health framework. This enables the development of legal tools that will give credibility, legitimacy, and accountability to the design, development, and implementation of a sustainable One Health framework through meaningful and inclusive societal engagement.