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1 results

  • TP53 mutation may underlie increasing incidence of external auditory canal carcinoma

  • A. Pandya, D. Chandrasekharan, K. Suchak, J. S. Virk
  • Journal:
    The Journal of Laryngology & Otology / Volume 139 / Issue 6 / June 2025
    Published online by Cambridge University Press:
    11 November 2024, pp. 482-487
    Print publication:
    June 2025
  • Background

    Primary neoplasm of the external auditory canal has historically been documented to have a low incidence rate of between one and six per million internationally, with UK incidence yet to be officially cited.

    Methods

    Here, we report a rise in incidence at a single UK trust with seven carcinomas (six T4 external auditory canal squamous cell and one T4 basal cell) reported within an 18-month period. All tumours underwent next generation sequencing.

    Results

    The cases recorded represented a twofold rise in incidence in reference to international literature from a population-adjusted estimate of 0.5–3 cases for the catchment area to seven cases. All cases were treated with temporal bone resections (n = 7) and with post-operative radiotherapy in six cases. Tumour analysis showed all were TP53 mutant and human papilloma virus (HPV)/P16 negative.

    Conclusion

    We suggest chronic inflammation and genetic alterations as putative contributory factors in our case series and outline clinical strategies for timely detection of external auditory canal neoplasms.