Disruptive behavior increases the risk of developing more severe behavior problems later in life, including antisocial and criminal behavior. Parents behavior, and possibly their genetic makeup as well, plays a key role in shaping their children’s disruptive behavior. We examined gene-environment (parenting) correlations as underlying mechanisms for disruptive child behavior in a cross-sectional study. Polygenic scores for disruptive and externalizing behavior (PGS-DB and PGS-EXT) and parent-reported harsh and warm-supportive parenting were measured in 288 Dutch parent-child pairs (Child Mage = 6.26, SD = 1.31, 48% girls) with above-average parent-reported disruptive behavior. Harsh and warm-supportive parenting and children’s PGS-DB were associated with disruptive child behavior (β = .23, .10 and .15, respectively), but no evidence emerged for gene-environment correlations or genetic nurture. However, harsh parenting was found to partially mediate the link between parental PGS-EXT and disruptive child behavior (β = .04). These findings suggest that the choice of polygenic scores may influence the ability to detect genetic nurture as a relevant mechanism underlying disruptive child behavior.