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1 results

  • The L6 membrane proteins—A new four-transmembrane superfamily

  • MARK D. WRIGHT, JIAN NI, GEORGE B. RUDY
  • Journal:
    Protein Science / Volume 9 / Issue 8 / August 2000
    Published online by Cambridge University Press:
    01 August 2000, pp. 1594-1600
    Print publication:
    August 2000

  • L6, IL-TMP, and TM4SF5 are cell surface proteins predicted to have four transmembrane domains. Previous sequence analysis led to their assignment as members of the tetraspanin superfamily. In this paper, we identify a new sequence (L6D) that is strikingly similar to L6, IL-TMP, and TM4SF5. Analyses of these four sequences indicate that they are not significantly related to genuine tetraspanins, but instead constitute their own L6 superfamily.