Within this study, an optimized ultra-wideband (UWB) multi-input multi-output (MIMO) antenna incorporating band-rejection features is introduced for wireless application. The proposed design comprises four circular single-element antenna units that are designed on a Rogers RT/duroid 5880 (tm) support material having an overall size of 80 × 80 × 0.8 mm3 or 0.72λ0 × 0.72λ0 × 0.0072λ0 (λ0 is the free-space wavelength at lowest frequency 2.7 GHz) and positioned perpendicularly. To enhance isolation, cross-shaped extensions are incorporated. Measurement results indicate that this antenna demonstrates an impedance bandwidth of −10 dB, spanning from 2.7 to 11.67 GHz (125%) and penta-notched filters for 3.2–4.0 GHz, 4.49–5.05 GHz, 5.56–6.16 GHz, 8.23–8.56 GHz, and 10.29–11.53 GHz. The presented antenna is capable of filtering signals from WiMAX (3.3–3.7 GHz), N79 band (4.8–4.9 GHz), WLAN downlink (5.725–5.825 GHz), ITU-R (8.275–8.5 GHz) and Ku-band downlink (10.7–11.2 GHz). The antenna exhibits envelope correlation coefficients (ECC) below 0.04 and provides isolation superior to 20 dB. Experimental results indicate that the simulated characteristics closely match the measured ones. The developed MIMO antenna demonstrates strong suitability for ultra-wideband (UWB) wireless communication applications.