Recent changes in artificial intelligence (AI) applications have made the technology accessible for practitioners in prehospital and disaster medicine in a way that was nearly unthinkable a few years ago. Initial anecdotal use of this technology has been met with enthusiasm and excitement. However, evidence-based research in the field is often lacking. The PDM Special Collection on Evidence-Based Artificial Intelligence in Prehospital and Disaster Medicine introduces a new forum for dissemination of innovative, high-impact research.