Global health emergencies (GHEs) are situations of heightened and widespread health crisis, that usually require the attention and mobilisation of actors and institutions beyond national borders. Conducting research in such contexts is both ethically imperative and requires particular ethical and regulatory scrutiny. While global health emergency research (GHER) serves a crucial function of learning how to improve care and services for individuals, it is difficult to fully capture the range of ethical considerations that arise, let alone provide a one-size-fits-all solution to such question. Using illustrations drawn from research projects conducted during GHEs, in this chapter we discuss key ethical issues and governance implications of GHER, beyond those traditionally associated with biomedical research, and explore the future direction of oversight for GHER. After setting out the complex context of GHER, we illustrate the various ethical issues associated with research and in justifying research, including considerations related to context, social value and engagement with the affected communities. Finally, we explore some of the new orientations and lenses in the governance of GHER through recent guidelines and developing practices.