Skip to main content Accessibility help
×
  1. Home
  2. Search

Refine search

Refine search

Access:
Content type:
Publication date:
Apply   From and To filters
Subject: Show more
Journals Show more
Publishers: Show more
Societies Show more
Series: Show more
Collections: Show more

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

2 results

  • Chapter 2.1 - Pharmacological Principles

  • from Sec 2 - Pharmacology
  • Edited by Rebecca Leslie, Royal United Hospitals NHS Foundation Trust, Bath, Emily Johnson, Worcester Acute Hospitals NHS Trust, Worcester, Alex Goodwin, Royal United Hospitals NHS Foundation Trust, Bath, Samuel Nava, Severn Deanery, Bristol
  • Book:
    Dr Podcast Scripts for the Primary FRCA
    Published online:
    19 June 2025
    Print publication:
    03 July 2025, pp 149-183

  • Summary

    This chapter covers the complex topics of pharmacokinetic and pharmacodynamics, core topics for anaesthetic exams and for practising anaesthetists. This includes route of drug administration, bioavailability, metabolism and elimination. We discuss one, two and three-compartment modelling for total intravenous anaesthesia including target-controlled infusion models. Pharmacodynamics covers drug-receptor interactions and their mechanism of action. This extends to drug isomerism, agonism and antagonism, and pharmacogenetics.

  • 6 - Protein Conjugation

  • David Pfister, Lucrèce Nicoud, Massachusetts Institute of Technology, Massimo Morbidelli, Eidgenössische Technische Hochschule Zürich
  • Book:
    Continuous Biopharmaceutical Processes
    Published online:
    22 September 2018
    Print publication:
    11 October 2018, pp 203-246

  • Summary

    This chapter deals with protein bioconjugation, which has emerged as an attractive technique to enhance therapeutic properties of protein-based drugs (e.g. in-vivo circulation, potency). The first part of this chapter aims at answering questions regarding the coupling chemistry and the modelling of the kinetics of bioconjugation. Then, the purification of conjugated proteins is addressed. In particular, chromatography is presented as a technique to purify conjugated proteins according to their extent of conjugation on the one hand and to the position of the conjugated groups on the other hand. Moreover, continuous technologies for both the conjugation reaction and the purification by chromatography are discussed. Finally, the potential benefits from the integration between the reaction and the purification steps in bioconjugation processes are examined. This chapter combines theoretical aspects, model simulations and experimental results from practical examples, for instance dealing with PEGylated proteins and antibody-drug conjugates.