Market-oriented theorizing fails to capture the reality of government intervention in the global economy. Trade and investment measures by governments around the globe, designed to protect strategic industries and maintain a security of supply in the wake of a return to strategic competition, are emblematic of the need to shift our analysis of the global economy. We have labeled this phenomenon “new economic statecraft” and have invited this special issue to examine this phenomenon across countries and sectors of the global economy. Traditionally, economists have largely focused on efficiency gains and the reduction of transaction costs rather than considering the political and strategic aspects of trade and capital flows. This existing analysis fails to capture the reality that many governments are using economic levers to compete in “strategic” sectors of their economy through intervention at the border, behind the border, and beyond the border. To analyze these phenomena, this article and the associated special issue investigates five theorized drivers of state intervention in the global economy to explain when and how governments intervene in their markets. We also hope that this approach can help guide further empirical work on state-business relations and global political and economic competition.