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1 results

  • Targeting the kynurenine pathway: a novel approach in tumour therapy

  • Shuoqi Lin, Genggeng Zheng, Yuxiang Yan, Tesen Liao, Bohua Su, Dali Zheng
  • Journal:
    Expert Reviews in Molecular Medicine / Volume 27 / 2025
    Published online by Cambridge University Press:
    05 March 2025, e22
    • Article
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  • Background

    Cancer cells interact with their surroundings to promote tumour formation and metastasis, often requiring a constant supply of amino acids. The reprogramming of tryptophan (Trp) metabolism is highly activated in tumours, providing essential biological raw materials and energy for malignant tumour progression. Among these metabolic pathways, the kynurenine pathway (KP) plays a crucial role, making it a promising target for tumour therapy.

    Methods

    This study comprehensively examines the roles of KP metabolites in tumour growth and evaluates therapeutic strategies targeting this pathway.

    Results

    Targeting the KP in Trp metabolism presents new possibilities for tumour treatment. The study highlights various strategies, including traditional inhibition of key enzymes, novel drug delivery systems for enzyme targeting and mechanism-derived combination therapies. These approaches aim to enhance the precision and effectiveness of tumour therapy by modulating KP activity.

    Conclusions

    A deeper understanding of KP metabolism in tumour progression opens new avenues for therapeutic intervention.