Abstract: By 2001, two years after approval, the new MassGeneral Institute for Neurodegenerative Disease (MIND) building was designed, built and opened. About 30 independent faculty laboratory heads occupied the laboratory floors. Each lab head had 5–15 people in their lab and in total about 300 people worked on the two main floors. Anne’s lab and office moved to MIND. Early on, she was still very depressed about Jack’s death and needed help to continue her research. Without Jack, Anne didn’t have enthusiasm or ambition. Zane Hollingsworth and Anne’s previous trainees, Jang-Ho Cha and David Standaert, helped Anne with her students, postdocs, technicians and grants. Anne was elected president of the American Neurological Association and then president of the Society for Neuroscience. Six years after Jack died, Anne received an email from her old eighth-grade and sometimes high school boyfriend, Stetson Ames. He was coming to Boston in May and asked Anne if she would like to meet. She and Stets eventually married. Anne inherited $2 million when her mother died, a million of which she donated to Mass General. Nancy Wexler began showing signs of Huntington’s disease. It was undeniable, but neither Anne nor Nancy could face the devastating possibility.

Anne was one of a handful of women in neurology who were truly ‘academic’ – doing NIH-supported research, teaching students and residents, and seeing and treating neurological patients. In 1990, Anne received a letter from the Massachusetts General Hospital asking if she would be willing to be a candidate for chair of the Department of Neurology at the hospital and Julieanne Dorn Professor of Neurology at Harvard Medical School. Since she was happy in Michigan, she usually declined these letters, but this one piqued Anne’s interest. Massachusetts General Hospital was supposed to be the pinnacle of traditional, male-dominated medicine. Anne was eventually offered the position. She had to consider her family and if she really wanted to commit. Anne put together a five-year plan and had Nancy, Jack and Herb look at it before she sent it to Mass General. She spoke to Milton Wexler for advice on how to make the decision. Anne decided to take the job. Jack would be appointed professor of neurology and Zane instructor at Harvard Medical School. When she told Sid, he was sad to lose them but also proud that two of his ‘children’ were moving up to such a prestigious department. When she broke the news to her children that they would be moving across the country, Jessie showed enthusiasm and Ellen showed dismay.