Landscape evolution in karst terrains affects both subterranean and surface settings. For better understanding of controlling processes and connections between the two, multiple geochronometers were used to date sediments and speleothems in upper-level passages of Fitton Cave adjacent to the Buffalo River, northern Arkansas, within the southern Ozark Plateau. Burial cosmogenic-nuclide dating of coarse sediments indicates that gravel pulses washed into upper passages at 2.2 Ma and 1.25 Ma. These represent the oldest epigenetic cave deposits documented in this region. Associated sands and clay-rich sediments mostly have reversed magnetic polarity and thermally transferred optically stimulated luminescence dates of 1.2 to 1.0 Ma. Abandonment of these upper passages began before 0.72 Ma, when coarse sediment was deposited in a passage incised below older sediment. Maximum U-series dates of 0.7–0.4 Ma for flowstones capping clastic deposits mark the stabilization of older sediments and a change to vadose conditions that allowed post–0.4 Ma stalagmite growth. Resulting valley incision rates since 0.85 Ma are estimated at 27 m/Ma. Coarse cave-sediment pulses correlate to Laurentide glacial tills about 300 km to the north, suggesting climate influence on periglacial sediment production. Dated cave sediments also may correlate with undated older strath terraces preserved at similar heights above the Buffalo River.