Using serum biomarkers that reflect fruit and vegetable (FV) intake offers a significant advantage over traditional dietary assessments by providing a more objective, accurate measure, meaningfully minimizing recall bias and misreporting common in self-reported dietary data. This study investigated the relationship between these serum biomarkers and mortality risk using data from 19,168 adults aged 30 and older who participated in the National Health and Nutrition Examination Survey (NHANES) from 1988 to 2006. Mortality follow-up was determined by linkage to the National Death Index through December 31, 2019, and diet by 24-h recalls. Cox proportional hazards models were employed to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality outcomes by tertiles of serum biomarkers of FV intake. Higher serum concentrations of total carotenoids were associated with a reduced risk of all-cause (Tertile 3 vs. Tertile 1 HR=0.69, 95% CI=0.61-0.78) and cancer mortality (HR=0.53, 95% CI=0.39-0.71). Greater serum concentrations of individual carotenoids, such as α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein and zeaxanthin, were also linked to lower risks of all-cause and cancer mortality. Higher serum potassium concentrations showed a trend toward an association with a greater risk of all-cause mortality. No significant associations were found between serum vitamin C concentrations and mortality outcomes in the overall analysis; however, in sex-stratified analyses, higher vitamin C concentrations were associated with reduced risk of all-cause and cancer mortality in women. These findings suggest that specific serum biomarkers of FV intake, particularly carotenoids and vitamin C, may serve as indicators of reduced mortality risk.

Previous studies have highlighted the health benefits of coffee and tea, but they only focused on the comparisons between different consumptions. Consequently, the association estimate lacked a clear interpretation, as the substitution of beverages and distribution of doses were not explicitly prescribed. We focused on the “relative association” to ascertain the optimal consumption strategy (including total intake and optimal allocation strategy) for coffee, tea, and plain water associated with decreased mortality. Self-reported coffee, tea, and plain water intake were used from the UK Biobank. Within a compositional data analysis framework, multivariate Cox model was used to assess the relative associations after adjusting for a range of potential confounders. The lower mortality risk was observed with at least approximately 7 to 8 drinks per day of total consumption. When the total intake > 4 drinks per day, substituting plain water with coffee or tea was linked to reduced mortality, nevertheless the benefit was not seen for ≤ 4 drinks per day. Besides, a balanced consumption of coffee and tea (roughly a ratio of 2:3) associated with the lowest hazard ratios of 0.55 (95% CI: 0.47−0.64) for all-cause mortality, 0.59 (95% CI: 0.48−0.72) for cancer mortality, 0.69 (95% CI: 0.49−0.99) for cardiovascular disease mortality, 0.28 (95% CI: 0.15−0.52) for respiratory disease mortality, and 0.35 (95% CI: 0.15−0.82) for digestive disease mortality than other combinations. These results highlight the importance of the rational combination of coffee, tea, and plain water, with particular emphasis on ensuring adequate total intake, offering more comprehensive and explicit guidance for individuals.

The aim of this study was to investigate the effects of gillnet soak time to gain a better understanding of fish welfare, mortality, stress, and quality (as measured as muscle haemoglobin) during experimental gillnet fishery of Atlantic cod (Gadus morhua). An experimental study was conducted in a large-scale tank at a research facility with 131 wild-caught fish in four groups with gillnet soak times of 0, 2, 12, and 24 h (23–34 fish per soak time). Longer soak time caused higher mortality, with a mortality rate of 0, 7, 18, and 25% in the 0-, 2-, 12- and 24-h groups, respectively. Blood lactate levels were significantly affected by soak time, peaking at 2 h (with the widest confidence interval) and showing their lowest concentrations at 0 and 24 h. Soak time also significantly increased blood glucose and serum cortisol levels. Magnesium, creatinine, and iron increased significantly in all groups compared with control levels, but there was no significant difference between soak times. Haemoglobin content in the loin increased significantly only after 24 h of soak time for live fish. There was no significant increase in haemoglobin in the belly as a function of soak time. However, for all soak times, the belly had significantly more haemoglobin than the loin. Physiological evidence of traumatic injuries and stress were noted prior to increased muscle haemoglobin, meaning that good quality did not necessarily equate to good welfare. However, a higher level of muscle haemoglobin is a strong indication of poor welfare.

The current study aims to assess associations between trimethylamine N-oxide (TMAO) levels and mortality and to investigate modification effects of genetics. A total of 500 participants from a family-based cohort study were enrolled from 2005 to 2017 and followed up until 2020 in Fangshan District, Beijing, China. Serum TMAO levels were measured using the ELISA kit. The primary outcomes were all-cause mortality and deaths from CVD and stroke. During a median follow-up time of 7·38 years, thirty-eight deaths were recorded, including twenty deaths due to CVD and nineteen deaths due to stroke. Compared with the lowest TMAO quartile group, the HR for all-cause mortality was 1·35 (95 % CI: 0·44, 4·15), 1·65 (95 % CI: 0·58, 4·64) and 2·45 (95 % CI: 0·91, 6·57), respectively, in higher groups. No association was observed between TMAO and CVD mortality. However, compared with the lowest TMAO concentration group, the HR for stroke mortality was 1·93 (95 % CI: 0·40, 9·39), 1·91 (95 % CI: 0·41, 8·96) and 4·16 (95 % CI: 0·94, 18·52), respectively, in higher groups (Pfor trend = 0·046). Furthermore, polygenic risk score (PRS) for longevity modified the association of TMAO with all-cause mortality (Pfor interaction = 0·008). The risk of mortality (HR = 2·20, 95 % CI: 1·06, 4·57) was higher among participants with lower PRS compared with higher PRS (HR = 1·00, 95 % CI: 0·71, 1·40). The study indicates that elevated serum TMAO levels are potentially associated with long-term mortality risk in rural areas of northern China, especially for stroke deaths. Additionally, it provides novel evidence that genetic variations might modify the association.

Case Presentation: A 68 year old man. Hospitalized with decreased consciousness. Experienced severe shortness of breath 3 days before entering the hospital. The patient also had wounds on his right and left legs since 1 month ago. But then became more widespread. The patient has kidney failure and routinely undergoes hemodialysis. The patient had diabetes since 6 years ago. Laboratory: Hemoglobin 7.5 Leukocytes 17.8 Netrophils 91.70 Lymphocytes 4.20 Albumin 2.2 Creatinine 2.5 Ureum 61 Artery 2.30, urine bacteria+++. Pus culture results: Enterobacter cloacae with the antibiotic meropenem. Sputum culture results Klebsiella pneumoniae ss. Pneumoniae with amikacin. After 1 week pus culture results: Pseudomonas aeruginosa with amikacin. Blood culture results: Staphylococcus epidermidis suggested vancomycin. The patient underwent debriment in the operating room. However, the condition did not improve. Discussion: This patient experienced sepsis with MDRO. Apart from geriatric age, the patient also has diabetes with complications of kidney failure. This worsens the patient’s immune system. So the patient’s diabetic ulcers and decubitus ulcers worsened with the results of cultures with various antibiotic-resistant multiorganisms. And also the respiratory infections increase the risk of mortality. Conclusion : MDRO is a risk factor for inappropriate antibiotic therapy, which is undoubtedly associated with increased mortality.

Figure :

Diabetic ulcers and decubitus ulcers in patient

Schizophrenia is known to be a disabling psychiatric condition with wide reaching impact on everyday functioning and outcomes. These functional outcomes include increases in all-cause mortality (especially suicide and injury), cognitive and functional capacity deficits, lower reported levels of quality of life (QoL), increased incarceration, higher risk for violence and victimization, and homelessness. Studies have shown that medications and outpatient services can improve each of these functional outcomes in individuals with schizophrenia. However, most studies of pharmacological treatment utilize rating scales that do not reflect these real-world outcomes. This review looks at available studies focused on real-world outcomes and argues for an expansion of this body of research.

Adherence to healthy dietary patterns, including fruits, vegetables and whole grains, is linked to improved health outcomes. However, limited research has explored this association in Latin American populations. This study aimed to investigate the association between adherence to a healthy eating score (unweighted and weighted) and all-cause mortality risk in a Chilean population. This longitudinal study included 5336 Chilean participants from the Chilean National Health Survey 2016 and 2017. Six healthy eating habits were considered to produce the healthy eating score (range: 0–12): consumption of seafood, whole grains, dairy products, fruits, vegetables and legumes. A weighted score was also developed. Participants were categorised into quartiles based on their final scores, with the healthiest quartile used as the reference group. Associations between healthy eating score and all-cause mortality were performed using Cox proportional hazard models adjusted for confounders. After a median follow-up of 5·1 years, 276 (5·2 %) participants died. In the fully adjusted model, compared with participants in the healthiest quartile of the score (Q4), those in the unhealthiest quartile (Q1) had 1·61 (95 % CI: 1·14, 2·27) times higher all-cause mortality risk. A similar association was observed for the weighted healthy eating score (1·52 (95 % CI: 1·03, 2·23)). An inverse trend was observed for both scores (P < 0·05). Sensitivity analyses excluding participants who died within the first 2 years showed consistent results 1·63 (95 % CI: 1·09, 2·42). Individuals with the lowest healthy eating score (unweighted or weighted) had a higher mortality risk compared with their counterparts. A healthy eating score is associated with mortality risk in the Chilean population.

As the population ages, the provision of adult long-term care (LTC) is one of the major challenges facing the UK and other developed nations. LTC funding for the elderly is complex, reflecting the range and level of services provided, with the total cost depending on the duration of LTC required. Institutional care settings (e.g., nursing/residential care homes) represent the most expensive form of LTC. Planning and funding for institutional LTC requires an understanding of the factors affecting the mortality (and hence duration and cost of care) of such LTC recipients. Using data provided by Bupa, one of the largest LTC providers in Britain, this paper investigates factors affecting the mortality of residents of institutional LTC facilities over the period 2016-2019. Consistent with existing research, most residents were female and had a higher average age profile compared with male residents. For those residents who died during the investigation period, the average length of stay was approximately 1.6 times longer for females relative to males. For both males and females, new residents experienced higher mortality in the first-year post admission compared to existing residents. Variations in the mortality of the residents were analysed by condition, funding status and care type on admission.

We examine the impact of decentralisation on COVID-19 mortality and various health outcomes. Specifically, we investigate whether decentralised health systems, which facilitated greater regional participation and information sharing, were more effective in saving lives. Our analysis makes three contributions. First, we draw on evidence from several European countries to assess whether the decentralisation of health systems influenced COVID-19 mortality rates. Second, we explore the regional disparities in one of the most decentralised health systems, Spain, to untangle some of the determinants shaping health outcomes. Third, we estimate the regional loss of Quality Adjusted Life Years (QALYs) due to COVID-19 mortality, broken down by the wave of the pandemic. Our findings suggest that coordinated decentralisation played a critical role in saving lives throughout the COVID-19 pandemic.