To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure no-reply@cambridge-org.demo.remotlog.com
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
The primary aim of this rapid review was to provide a summary of the mechanisms by which HFI is associated with child and adolescent health outcomes. The secondary aim was to identify key HFI determinants, provide an updated account of HFI-associated child/ adolescent health outcomes and build a conceptual map to illustrate and consolidate the findings.
Design
A rapid review was performed using EMBASE, Medline, Web of Science and The Cochrane library. Inclusion criteria were observational High- income English-language studies, studies evaluating the mechanisms and associations between HFI and child health outcomes using statistical methods.
Setting
High income English-speaking countries.
Participants
Child (3-10 years) and adolescent populations (11-24 years) and their parents, if appropriate.
Results
Eight studies reported on the mechanisms by which HFI is related to child health outcomes, suggesting that maternal mental health and parenting stress play mediating roles between HFI and child/adolescent mental health, behaviour and child weight status. Sixty studies reported on associations between HFI and various child health outcomes. HFI had significant impact on diet and mental health, which appeared to be interrelated. Sociodemographic factors were identified as determinants of HFI and moderated the relationship between HFI and child/adolescent health outcomes.
Conclusions
There is a gap in the evidence explaining the mechanistic role of diet quality between HFI and child weight status, as well as the interplay between diet, eating behaviours and mental health on physical child health outcomes. The conceptual map highlights opportunities for intervention and policy evaluations using complex systems approaches.
A lack of common terminology and shared understanding of behavioural interventions across academic disciplines and professional groups limits the multidisciplinary application of such interventions and our collective ability to share and compare their effects. The current study attempts to narrow this gap by developing a comprehensive classification system of nudges and similar behavioural interventions that can aid researchers and practitioners in understanding and describing such interventions to steer desired behaviour change. We develop an initial classification system drawing on our expert knowledge and subsequently validate it in an iterative procedure with 44 experts from various fields, disciplines and sectors during two feedback rounds (i.e. a Delphi approach). The result is META BI (Mapping of Environment, Target group and Agent for Behavioural Interventions), a classification system describing interventions across 20 dimensions and using 17 distinct psychological mechanisms. META BI is aligned with a system lens, shifting the focus from single true effects to contextualised assessments. It can help to understand, compare and evaluate nudges and selected interventions for the desired effects.
Sulforaphane (SFN), a bioactive compound derived from glucoraphanin in cruciferous vegetables such as broccoli, has been extensively studied for its therapeutic potential across diverse disease categories. SFN exerts its effects through well-characterised pathways, including the Keap1/Nrf2 axis, which regulates phase II detoxification enzymes, and epigenetic mechanisms such as histone deacetylase inhibition. This review evaluates clinical trials registered on ClinicalTrials.gov, focusing on those using SFN or broccoli-derived extracts.
As a result, we identified 84 trials, of which 39 have been published. Results suggest SFN’s potential in regulating redox and inflammatory pathways, improving metabolic and cardiovascular outcomes, and exerting anti-cancer and neuroprotective effects. For healthy subjects, SFN enhanced detoxification and reduced inflammation. In cancer patients, SFN showed promise in early-stage prostate and breast cancer, particularly in GSTM1-positive individuals, but had limited effects in advanced cases. For brain disorders, SFN demonstrated symptomatic improvements in autism spectrum disorder and cognitive benefits in schizophrenia but lacked robust biomarker integration. SFN had minimal impact on respiratory diseases but showed supportive roles in allergic rhinitis therapy. Metabolic disease studies revealed glycaemic control improvements in type 2 diabetes but no benefits for hypertension. Approximately 50% of completed trials remain unpublished, raising concerns about publication bias. While published results highlight SFN’s therapeutic potential, limited sample sizes and inconsistent outcomes underscore the need for more extensive, stratified trials. This review emphasises the importance of integrating mechanistic insights and precision medicine approaches to maximise SFN’s clinical utility.
Corporate boards, experts panels, parliaments, cabinets, and even nations all take important decisions as a group. Selecting an efficient decision rule to aggregate individual opinions is paramount to the decision quality of these groups. In our experiment we measure revealed preferences over and efficiency of several important decision rules. Our results show that: (1) the efficiency of the theoretically optimal rule is not as robust as simple majority voting, and efficiency rankings in the lab can differ from theory; (2) participation constraints often hinder implementation of more efficient mechanisms; (3) these constraints are relaxed if the less efficient mechanism is risky; (4) participation preferences appear to be driven by realized rather than theoretic payoffs of the decision rules. These findings highlight the difficulty of relying on theory alone to predict what mechanism is better and acceptable to the participants in practice.
The concluding chapter discusses the implications of Hong Kong’s contentious politics within the global context of democratic backsliding and spontaneous mass mobilizations. We highlight the contributions of our theoretical framework and the implications of Hong Kong’s contentious pathways for hybrid regimes and beyond.
In this chapter I return to the classics of bellicist theory to formalize their insights and derive concrete observational expectations for nineteenth-century Latin America. I first look at the work of Otto Hintze and Max Weber, who suggest a more holistic approach to the effects of war on the process of state formation which combines both pre-war and post-war phases in a single overarching theory. I then use the more modern concepts and logics of historical institutionalism to generate clearer predictions from their theories. I propose that, in a pre-war phase and when hostilities are taking place, mobilization will trigger taxation and repression—i.e., the extraction-coercion cycle. Yet, war outcomes will determine whether those contingent policies will become institutionalized after the critical juncture of war. While victory will consolidate a trajectory of state formation, defeat will render state institutions illegitimate and set losers into a path-dependent process of state weakening. Finally, I discuss actors and mechanisms specific to nineteenth-century Latin America and lay out the observational implications of my argument.
Why and how we age are deep and enduring questions. The quest for a theoretical framework explaining the evolutionary origins and proximate mechanisms of ageing has led to the elaboration of hundreds of theories of very diverse kinds. The aim of this chapter is twofold. First, it will provide an historical perspective of the numerous theories of ageing. Second, it will emphasize the need for a unified framework merging both evolutionary and mechanistic theories by demonstrating that such theoretical frameworks are required to promote innovative research projects involving the joint effort of multiple research disciplines.
Unconsolidated soils typically develop a physical surface crust after wetting and drying. We reproduced this process in the laboratory by wetting with fog and simulated rain on fallow agricultural soils from 26 locations, representing 15 soil types from Pinal County, Arizona. Through correlative analyses, we found that carbonate content was a strong predictor of physical crust strength with fog (p < 0.0001, R2 = 0.48) and rain (p = 0.004, R2 = 0.30). Clay content increased crust strength (p = 0.04) but was not a useful predictor. Our results extend the current understanding of the soil crusting process by highlighting the preeminence of carbonate cementation in desert agricultural soils. Consequently, we identify carbonate as a pragmatic tool for estimating crust strength, a surrogate measure of a soil’s potential to produce fugitive dust, which can help prioritize interventions to curb airborne dust in arid lands.
The introductory chapter (Chapter 1) introduces the empirical and theoretical puzzles that motivate this project and presents a brief overview of the book as a whole. I present and motivate the empirical puzzle at the heart of the book and situate the reclassification reversal as a case of identity change and politicization. I then provide an overview of the central argument and mechanisms, and discuss alternative explanations tied to affirmative action and other prevailing explanations that do not adequately explain the puzzle. Next, I discuss the research design, methods, and positionality. I conclude the chapter with an outline of what is to come.
Chapter 3 details the argument to explain the reclassification reversal and elaborates the causal mechanisms. I begin by defining the concept of “political identity” as I use it throughout this work, distinguishing it from related concepts like social identity. I then argue that institutional change in national-level social policies brought about unprecedented access to education for lower-class citizens (who are likely candidates for reclassification) and show the evolution in educational access from the 1980s to the 2010s. At the individual level, greater education increased the exposure of individuals to racial hierarchies and inequalities, leading them to develop racialized political identities and choose blackness. I identify three main causal pathways: greater exposure to (1) information, (2) social contacts and networks, and (3) labor market experiences and discrimination. I conclude by summarizing the novelty of the hypothesis and the observable implications I test empirically in the chapters that follow.
Wars and genocides only bring desolation. Of course, we first think about the dramatic psychological consequences of those who survived extermination or those who have witnessed their families and friends being killed or mutilated. Psychological and neuroscience research have shown that surviving a psychological trauma leaves long-lasting imprints on individuals with notable life-long post-traumatic stress disorder (PTSD) symptoms, which can also extend to the following generations. Importantly, the psychological disaster observed in the aftermath of a war or a genocide not only touches the victims, their relatives, or their descendants. It also has disastrous consequences on the mental health of the assailants. The chapter argues that in order to stop the cycle of conflicts, we must also understand how both victims and assailants are impacted at the psychological level by their respective experience, and how to help them overcome their demons and potential feelings of revenge. Taking care of their mental health is a step towards stopping cycles of conflict.
Nuclear and chemical weapons of mass destruction share both a tragic and beneficial legacy in mankind’s history and health. The horrific health effects of ionizing radiation and mustard gas exposures unleashed during disasters, wars, and conflicts have been harnessed to treat human health maladies. Both agents of destruction have been transformed into therapies to treat a wide range of cancers. The discovery of therapeutic uses of radiation and sulfur mustard was largely due to observations by clinicians treating victims of radiation and sulfur mustard gas exposures. Clinicians identified vulnerability of leukocytes to these agents and repurposed their use in the treatment of leukemias and lymphomas. Given the overlap in therapeutic modalities, it goes to reason that there may be common mechanisms to target as protective strategies against their damaging effects. This commentary will highlight oxidative stress as a common mechanism shared by both radiation and sulfur mustard gas exposures and discuss potential therapies targeting oxidative stress as medical countermeasures against the devastating lung diseases wrought by these agents.
This chapter provides an overview of the antiviral drugs currently available, including maraviroc, aciclovir, penciclovir, ganciclovir, amantadine, zydovudine, adefovir, ribavirin, indinavir , oseltamivir, zanamivir, interferon alpha, rituximab , palivizumab, cidofovir, brincidofovir, foscarnet, remdesivir and paxlovid with an indication of their modes of action for treating virus infections, including HIV, herpes viruses, respiratory viruses, HBV, HCV, CMV, adenoviruses , BK, EBV (especially for PTLD), RSV, poxviruses and SARS-CoV-2.
Edited by
David Kingdon, University of Southampton,Paul Rowlands, Derbyshire Healthcare NHS foundation Trust,George Stein, Emeritus of the Princess Royal University Hospital
The chapter describes the history, mechanisms and phases of drug treatment of antipsychotics including at-risk mental states (ARMS), first-episode psychosis (FEP), maintenance, treatment-resistant schizophrenia (TRS) and ultra-resistant psychosis. Specific treatments of schizoaffective disorder, catatonia and affective comorbidities of psychosis target negative symptoms and cognition. Rapid tranquilisation is described: general principles, de-escalation, routes of administration and medication selection. Management of organic psychotic disorders is discussed: general principles and specific conditions, epilepsy, Huntington’s, stroke, drug-induced, autoimmune encephalitis, inflammatory, CNS infections, thyroid disorders and traumatic brain injury. Side effects are elaborated: somnolence and sedation; hyperprolactinaemia and sexual dysfunction; motor, cardiac, metabolic and anticholinergic side effects; and also diabetes and impaired glucose tolerance and clozapine-specific side effects. Finally, potential drug interactions are explored.
We compared dissociative seizure specific cognitive behavior therapy (DS-CBT) plus standardized medical care (SMC) to SMC alone in a randomized controlled trial. DS-CBT resulted in better outcomes on several secondary trial outcome measures at the 12-month follow-up point. The purpose of this paper is to evaluate putative treatment mechanisms.
Methods
We carried out a secondary mediation analysis of the CODES trial. 368 participants were recruited from the National Health Service in secondary / tertiary care in England, Scotland, and Wales. Sixteen mediation hypotheses corresponding to combinations of important trial outcomes and putative mediators were assessed. Twelve-month trial outcomes considered were final-month seizure frequency, Work and Social Adjustment Scale (WSAS), and the SF-12v2, a quality-of-life measure providing physical (PCS) and mental component summary (MCS) scores. Mediators chosen for analysis at six months (broadly corresponding to completion of DS-CBT) included: (a) beliefs about emotions, (b) a measure of avoidance behavior, (c) anxiety and (d) depression.
Results
All putative mediator variables except beliefs about emotions were found to be improved by DS-CBT. We found evidence for DS-CBT effect mediation for the outcome variables dissociative seizures (DS), WSAS and SF-12v2 MCS scores by improvements in target variables avoidance behavior, anxiety, and depression. The only variable to mediate the DS-CBT effect on the SF-12v2 PCS score was avoidance behavior.
Conclusions
Our findings largely confirmed the logic model underlying the development of CBT for patients with DS. Interventions could be additionally developed to specifically address beliefs about emotions to assess whether it improves outcomes.
We argue that behavioural public policies (BPP) should be categorized by the kind of mechanism through which they operate, not by the kind of treatment they implement. Reviewing the energy consumption BPP literature, we argue (i) that BPPs are currently categorized by treatment; (ii) that treatment-based categories are subject to mechanistic heterogeneity: there is substantial variation of mechanisms within each treatment type; and (iii) that they also display mechanistic overlap: there is substantial overlap between mechanisms across treatment types. Consequently, current categorizations of BPPs do not reveal the conditions of their efficacy and should be revised to better reflect mechanistic information.
This book explores some implications of studying international relations from a systemic perspective. This chapter takes on the preliminary tasks of defining systems, identifying distinctive characteristics of systemic explanations, and situating systems approaches in a broader context of relational framings. A system is a bounded set of components of particular types, arranged in definite ways, operating in a specific fashion to produce characteristic outcomes, some of which are emergent. The arrangement and operation of the components produce “emergent” “systems effects;” properties and outcomes that cannot be fully understood through knowledge of the parts considered separately. I emphasize the relational character of systemic explanations and their reliance on mechanisms and processes, in order to foster developing a relational processual systemic perspective within a pluralistic IR.